Boston, MANCT05293600Now EnrollingIRB Ready

Obstructive Sleep Apnea Clinical Trial in Boston, MA

Access cutting-edge obstructive sleep apnea treatment through this clinical trial at a research site in Boston. Study-provided care at no cost to qualified participants.

Sponsored by Brigham and Women's Hospital

Quick Self-Assessment

See if you qualify for this Boston location

Preparing your pre-screening questions…

Expert Care in Boston

Access obstructive sleep apnea specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related obstructive sleep apnea treatment provided free

Apply for This Boston Location

Check if you qualify for this obstructive sleep apnea clinical trial in Boston, MA

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Boston

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Boston site if eligible
  4. 4Begin participation

About This Obstructive Sleep Apnea Study in Boston

Persistent obstructive sleep apnea (OSA) is common in people treated with mandibular advancement device (MAD) or hypoglossal nerve stimulation (HGNS). For most patients, these treatments are the last line of defense. If MAD or HGNS do not work, then patients are left to suffer the consequences of undertreated OSA. In this study, the investigators want to test the addition of a drug treatment to their regimen. Endotypes will be targeted pharmacologically with one of the following drugs: acetazolamide for a high loop gain, atomoxetine-plus-eszopiclone for poor pharyngeal muscle compensation, or trazodone for a low arousal threshold. This aim is expected to provide treatment strategies for rescuing non-responders to MAD or HGNS therapy.

Sponsor: Brigham and Women's Hospital

Who Can Participate

Inclusion Criteria

Individuals who have failed MAD or HGNS therapy, defined as a residual AHI ≥ 15 events/hr on MAD or HGNS therapy.

Exclusion Criteria

Sleep disordered breathing or respiratory disorders other than obstructive sleep apnea: central sleep apnea (\>50% of respiratory events scored as central), chronic hypoventilation/hypoxemia (awake SaO2 \< 92% by oximetry) due to chronic obstructive pulmonary disease or other respiratory conditions.
Other sleep disorders: periodic limb movements (periodic limb movement index \> 20/hr), narcolepsy, or parasomnias.
Any unstable major medical condition.
Medications expected to stimulate or depress respiration (including opioids, barbiturates, benzodiazepines, doxapram, almitrine, theophylline, 4-hydroxybutanoic acid).
Use of SSRIs/SNRIs.
Contraindications for atomoxetine, including:
pheochromocytoma
use of monoamine oxidase inhibitors
benign prostatic hypertrophy, urinary retention
untreated narrow angle glaucoma
bipolar disorder, mania, psychosis
clinically significant constipation, gastric retention
pre-existing seizure disorders
clinically-significant kidney disorders
clinically-significant liver disorders
clinically-significant cardiovascular conditions
severe hypertension (SBP\>180 mmHg or DBP\>110 mmHg measured at baseline)
cardiomyopathy (LVEF\<50%) or heart failure
advanced atherosclerosi
history of cerebrovascular events
history of cardiac arrhythmias e.g., atrial fibrillation, QT prolongation
other serious cardiac conditions that would raise the consequences of an increase in blood pressure or heart rate
myasthenia gravis
pregnancy/breast-feeding
Contraindications for eszopiclone, including:
Hypersensitivity to eszopiclone
Chronic Obstructive Pulmonary Disease (COPD)
Breast feeding
Liver disease
Contraindications for acetazolamide, including:
Hyperchloremic acidosis
Hypokalemia
Hyponatremia
Adrenal insufficiency
Impaired kidney function
Hypersensitivity to acetazolamide or other sulfonamides.
Marked liver disease or impairment of liver function, including cirrhosis.
Contraindications for trazodone, including:
suicidal ideation
bipolar disorder, mania
use of monoamine oxidase inhibitors
coronary artery disease
cardiac arrhythmias
QT prolongation
hepatic disease
renal failure or impairment
closed angle glaucoma
pregnancy/breast-feeding

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT05293600) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Obstructive Sleep Apnea Treatment Options in Boston, MA

If you're searching for obstructive sleep apnea treatment options in Boston, MA, this clinical trial (NCT05293600) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced obstructive sleep apnea specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all obstructive sleep apnea clinical trials near you to find additional studies recruiting in your area.

More Lupus Trials in Boston, MA

See all lupus clinical trials recruiting in Boston — not just this study.

Browse Lupus Trials in Boston →

Browse More Trials by Condition

Lupus TrialsUlcerative Colitis TrialsSleep Apnea TrialsPrurigo Nodularis TrialsSystemic Lupus Erythematosus TrialsAll Conditions →

Ready to Join in Boston?

Take the first step toward participating in this groundbreaking clinical trial

Secure · Expert Care · Boston, MA