Silver Spring, MDNCT04401982Now EnrollingIRB Ready

Ocular Hypertension Clinical Trial in Silver Spring, MD

Access cutting-edge ocular hypertension treatment through this clinical trial at a research site in Silver Spring. Study-provided care at no cost to qualified participants.

Sponsored by University of Maryland, Baltimore

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Expert Care in Silver Spring

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related ocular hypertension treatment provided free

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Why Participate?

  • No-Cost Study Care

  • Local to Silver Spring

    Convenient for MD residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Silver Spring site if eligible
  4. 4Begin participation

About This Ocular Hypertension Study in Silver Spring

The goal of this clinical trial is to compare participants treated with latanoprost to those treated with Rocklatan (netarsudil/latanoprost) to determine whether the addition of netarsudil results in greater improvements in episcleral venous blood flow in adults with glaucoma or ocular hypertension. Episcleral venous blood flow will be measured using erythrocyte-mediated angiography (EMA) and laser speckle contrast imaging (LSCI). The main questions this study aims to answer are: * Does Rocklatan produce greater increases in episcleral venous blood flow than latanoprost alone? * Can EMA and LSCI reliably detect changes in episcleral venous blood flow following treatment with these medications? Participants will: * Be randomized to receive either latanoprost or Rocklatan * Undergo imaging of the episcleral veins using EMA and LSCI before, during, and after treatment, and * Complete study visits that include standard ophthalmic examinations and intraocular pressure measurements. Hypothesis: The investigators hypothesize that latanoprost, which primarily increases uveoscleral outflow, will not significantly affect the distal episcleral circulation. In contrast, Rocklatan, through its netarsudil component, is expected to produce measurable increases in episcleral venous flow.

Sponsor: University of Maryland, Baltimore

Who Can Participate

Inclusion Criteria

Patients are at least 18 years of age.
Patients must have ocular hypertension or be a glaucoma suspect.
Patient must not have used any IOP-lowering medication (topical or systemic) within the past 6 months
Patients must have open angles on gonioscopy.
All patients will have at least one recorded visual field examination within 6 months of enrollment in the study. Visual fields will be assessed using the Hodapp-Andersen-Parish criteria.

Exclusion Criteria

Participation in other investigational studies, unless such participation does not involve the administration of any drugs or agents that could impact the results of this study or have an effect on episcleral flow, as determined by the Investigator.
Prior intraocular surgery other than uncomplicated cataract surgery.
Allergy or history of adverse reaction to ICG, shellfish, or Iodine.
Significant liver disease or uremia.
Secondary glaucoma including exfoliation glaucoma, pigmentary glaucoma, or history of acute angle closure.
Moderate or severe visual field deficits as per Hodapp-Anderson-Parish criteria.
Any condition precluding imaging including reliable visual fields, disc photography, or use of study treatments including media opacity or tilted optic disk
Pregnant or nursing patients.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Silver Spring?

Yes, this clinical trial (NCT04401982) has an active research site in Silver Spring, MD that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Ocular Hypertension Treatment Options in Silver Spring, MD

If you're searching for ocular hypertension treatment options in Silver Spring, MD, this clinical trial (NCT04401982) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Silver Spring research site is actively enrolling participants for this clinical trial. You'll receive care from experienced ocular hypertension specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all ocular hypertension clinical trials near you to find additional studies recruiting in your area.

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