New Haven, CTNCT06800703Now EnrollingIRB Ready

Opioid Use Disorder Clinical Trial in New Haven, CT

Access cutting-edge opioid use disorder treatment through this clinical trial at a research site in New Haven. Study-provided care at no cost to qualified participants.

Sponsored by Yale University

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Expert Care in New Haven

Access opioid use disorder specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related opioid use disorder treatment provided free

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Check if you qualify for this opioid use disorder clinical trial in New Haven, CT

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to New Haven

    Convenient for CT residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit New Haven site if eligible
  4. 4Begin participation

About This Opioid Use Disorder Study in New Haven

The goal of this observational study is to characterize the brain processes of pain avoidance learning dysfunctions in individuals with opioid use disorder (OUD). The main questions it aims to answer are: Compared with healthy controls, do those with OUD exhibit impaired avoidance learning in response to pain? What are the brain processes that are associated with this avoidance learning dysfunction? Do these brain processes serve to predict future use or relapse? Researchers will compare those with OUD and healthy controls to determine avoidance learning dysfunction and its relationship with opioid use. Participants will be performing a learning task inside an fMRI scanner. Those with OUD will also be followed up for a year to determine future opioid use.

Sponsor: Yale University

Who Can Participate

Inclusion Criteria

in the study, an individual must meet all of the following criteria:
Between ages 21-60 years old.
Able to read and write and provide written informed consent.
Meet DSM-5 criteria for moderate to severe opioid use disorder; self-reported excessive opioid use prior to study entry and verified by urine toxicology testing; seeking treatment for their OUD.
Physically healthy with no major medical illnesses, history of head injury or any neurological illness
No plans to relocate out of state in the next 12 months (for follow-up purposes).
Currently seeking treatment or currently receiving treatment for OUD.
Speak English
Have been enrolled in an inpatient or outpatient treatment program for OUD for at least 4 weeks.

Exclusion Criteria

Any significant current medical condition such as neurological, cardiovascular, endocrine, renal, hepatic, thyroid pathology.
History of head injury with loss of consciousness (\> 30 minutes).
Current or past DSM-IV or DSM 5 diagnosis of a major psychiatric disorder (other than opioid and nicotine use disorders) that required hospitalization, or that required daily medications for over 4 weeks. Such medications include antidepressants, anticholinergics, antipsychotics, anxiolytics, lithium, psychotropic drugs not otherwise specified including herbal products, drugs with psychomotor effects or with anxiolytics, stimulant, or antipsychotic properties, any other psychoactive drugs, and sedatives/hypnotics. Individuals with current depressive or anxiety symptoms requiring treatment or currently being treated for these symptoms will be excluded.
Any subjects with foreign ferromagnetic metal objects in their body or other MR contraindications will be excluded. Individuals who previously worked in metal industry or with metal shavings (due to a risk of any remaining metal particles moving in the eye during the MRI).
Pregnant or lactating women will not be recruited for the study.
Cannot or are not willing to lie comfortably flat on his/her back for up to 2 hours in the MRI scanner (self-report).
Body weight \> 550 lbs. The MR scanner bed is tested to a weight limit of 550 lbs.
No pPlans to relocate out of state in the next 12 months (for follow-up purposes).
Still experiencing significant withdrawal symptoms. Individuals with regular opioid use To be eligible for inclusion in the study, an individual must meet all of the following criteria:
Between ages 21-60 years old.
Able to read and write and provide written informed consent.
Use non-prescribed opioids on a weekly basis or more.
Physically healthy with no major medical illnesses, history of head injury or any neurological illness
No plans to relocate out of state in the next 12 months (for follow-up purposes).
Speak English Exclusion Criteria:
Any significant current medical condition such as neurological, cardiovascular, endocrine, renal, hepatic, thyroid pathology.
History of head injury with loss of consciousness (\> 30 minutes).
Current or past DSM-IV or DSM 5 diagnosis of a major psychiatric disorder (other than opioid and nicotine use disorders) that required hospitalization, or that required daily medications for over 4 weeks. Such medications include antidepressants, anticholinergics, antipsychotics, anxiolytics, lithium, psychotropic drugs not otherwise specified including herbal products, drugs with psychomotor effects or with anxiolytics, stimulant, or antipsychotic properties, any other psychoactive drugs, and sedatives/hypnotics. Individuals with current depressive or anxiety symptoms requiring treatment or currently being treated for these symptoms will be excluded.
Any subjects with foreign ferromagnetic metal objects in their body or other MR contraindications will be excluded.
Pregnant or lactating women will not be recruited for the study.
Cannot or are not willing to lie comfortably flat on his/her back for up to 2 hours in the MRI scanner (self-report).
Body weight \> 550 lbs. The MR scanner bed is tested to a weight limit of 550 lbs. Individuals with regular opioid use To be eligible for inclusion in the study, an individual must meet all of the following criteria:
Between ages 21-60 years old.
Able to read and write and provide written informed consent.
Use non-prescribed opioids on a weekly basis or more.
Physically healthy with no major medical illnesses, history of head injury or any neurological illness
No plans to relocate out of state in the next 12 months (for follow-up purposes).
Speak English Exclusion Criteria:
Any significant current medical condition such as neurological, cardiovascular, endocrine, renal, hepatic, thyroid pathology.
History of head injury with loss of consciousness (\> 30 minutes).
Current or past DSM-IV or DSM 5 diagnosis of a major psychiatric disorder (other than opioid and nicotine use disorders) that required hospitalization, or that required daily medications for over 4 weeks. Such medications include antidepressants, anticholinergics, antipsychotics, anxiolytics, lithium, psychotropic drugs not otherwise specified including herbal products, drugs with psychomotor effects or with anxiolytics, stimulant, or antipsychotic properties, any other psychoactive drugs, and sedatives/hypnotics. Individuals with current depressive or anxiety symptoms requiring treatment or currently being treated for these symptoms will be excluded.
Any subjects with foreign ferromagnetic metal objects in their body or other MR contraindications will be excluded.
Pregnant or lactating women will not be recruited for the study.
Cannot or are not willing to lie comfortably flat on his/her back for up to 2 hours in the MRI scanner (self-report).
Body weight \> 550 lbs. The MR scanner bed is tested to a weight limit of 550 lbs. Individuals with regular opioid use To be eligible for inclusion in the study, an individual must meet all of the following criteria:
Between ages 21-60 years old.
Able to read and write and provide written informed consent.
Use non-prescribed opioids on a weekly basis or more.
Physically healthy with no major medical illnesses, history of head injury or any neurological illness
No plans to relocate out of state in the next 12 months (for follow-up purposes).
Speak English Exclusion Criteria:
Any significant current medical condition such as neurological, cardiovascular, endocrine, renal, hepatic, thyroid pathology.
History of head injury with loss of consciousness (\> 30 minutes).
Current or past DSM-IV or DSM 5 diagnosis of a major psychiatric disorder (other than opioid and nicotine use disorders) that required hospitalization, or that required daily medications for over 4 weeks. Such medications include antidepressants, anticholinergics, antipsychotics, anxiolytics, lithium, psychotropic drugs not otherwise specified including herbal products, drugs with psychomotor effects or with anxiolytics, stimulant, or antipsychotic properties, any other psychoactive drugs, and sedatives/hypnotics. Individuals with current depressive or anxiety symptoms requiring treatment or currently being treated for these symptoms will be excluded.
Any subjects with foreign ferromagnetic metal objects in their body or other MR contraindications will be excluded.
Pregnant or lactating women will not be recruited for the study.
Cannot or are not willing to lie comfortably flat on his/her back for up to 2 hours in the MRI scanner (self-report).
Body weight \> 550 lbs. The MR scanner bed is tested to a weight limit of 550 lbs. Healthy controls (HC) Inclusion Criteria
Between ages 1821-60 years old.
Able to read and write and provide written informed consent.
Demographics matching OUD participants.
Speak English Exclusion Criteria:
Meet criteria for current or history of any Axis I (except nicotine use) disorder.
Any significant current medical condition such as neurological, cardiovascular, endocrine, renal, hepatic, thyroid pathology. History of head injury with loss of consciousness (\> 30 minutes). 4\. Any subjects with foreign ferromagnetic metal objects in their body or other MR contraindications will be excluded. 5\. Pregnant or lactating women will not be recruited for the study. 6. Cannot or are not willing to lie comfortably flat on his/her back for up to 2 hours in the MRI scanner (self-report). 7\. Body weight \> 550 lbs. The MR scanner bed is tested to a weight limit of 550 lbs.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in New Haven?

Yes, this clinical trial (NCT06800703) has an active research site in New Haven, CT that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Opioid Use Disorder Treatment Options in New Haven, CT

If you're searching for opioid use disorder treatment options in New Haven, CT, this clinical trial (NCT06800703) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our New Haven research site is actively enrolling participants for this clinical trial. You'll receive care from experienced opioid use disorder specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all opioid use disorder clinical trials near you to find additional studies recruiting in your area.

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