Madison, WINCT04161066Now EnrollingIRB Ready

Opioid Use Disorder Clinical Trial in Madison, WI

Access cutting-edge opioid use disorder treatment through this clinical trial at a research site in Madison. Study-provided care at no cost to qualified participants.

Sponsored by University of Wisconsin, Madison

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Expert Care in Madison

Access opioid use disorder specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related opioid use disorder treatment provided free

Apply for This Madison Location

Check if you qualify for this opioid use disorder clinical trial in Madison, WI

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Madison

    Convenient for WI residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Madison site if eligible
  4. 4Begin participation

About This Opioid Use Disorder Study in Madison

Primary Aim: In participants with OUD, to characterize adverse events associated with adding two psilocybin doses to a stable buprenorphine-naloxone formulation. Secondary Aim: To evaluate the effect of psilocybin treatment on the effectiveness of a buprenorphine-naloxone maintenance therapy. Secondary Aim: To evaluate the effect of concurrent buprenorphine-naloxone use on the effects of psilocybin therapy. Descriptive Aim: To describe any changes in self-efficacy, quality of life, pain.

Sponsor: University of Wisconsin, Madison

Who Can Participate

Inclusion Criteria

Aged 21 to 65 years
Able to read, speak, and understand spoken and written English
Diagnosis of moderate or severe opioid use disorder (OUD)
Current opioid misuse, with misuse occurring on at least 10 of the last 30 days (at least 5 of last 30 days if already on buprenorphine/naloxene. See

Exclusion Criteria

#1). Misuse will be defined as either:
Use of illicit opioids, such as heroin or street fentanyl; or use of a prescription opioid (such as oxycodone, morphine, or hydrocodone) through a route (e.g. nasal, injected) other than FDA approved , and/or
Use of a prescription opioid for a purpose (e.g. intoxication, anxiety relief) other than that for which it was prescribed.
Able to achieve stable daily dose of a buprenorphine-naloxone formulation that controls opioid withdrawal symptoms
Persons of childbearing potential must agree to practice an effective means of contraception throughout their participation in the study, beginning at screening and throughout follow-up
Ability and willingness to adhere to study requirements, including attending all study visits, preparatory and follow-up sessions, and evaluations
Healthy kidney function
Able to provide contact information for a local support person. This person must be available during both 24-hour treatment and observation periods, and willing to provide the participant social/emotional support the day after each treatment and as needed during the dosing day and/or overnight observation period. Exclusion Criteria:
Currently prescribed and has taken buprenorphine or buprenorphine formulation (e.g., Suboxone®) for over four months immediately prior to initial study contact
Currently receiving pharmacotherapy of any duration with methadone
Current participation in a drug treatment court program or other legal supervision. Individuals who are under legal supervision will be advised that participating in this study could potentially violate terms of probation, parole, or extended supervision. Contact information for the individual's community supervision officer must be collected to confirm whether study participation may impact the potential participant's status on probation or parole
Inadequately treated hypertension
Current acute coronary syndrome or angina
Evidence of ischemic disease, cardiac conduction defects, and/or ventricular arrhythmias on screening ECG
History of heart transplant
Current insulin dependence, due to Type I or Type II diabetes
Urine drug test containing non-prescribed drugs of abuse
Any finding(s), based on the screening process, that the PI feels makes the study unsuitable for the participant

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Madison?

Yes, this clinical trial (NCT04161066) has an active research site in Madison, WI that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Opioid Use Disorder Treatment Options in Madison, WI

If you're searching for opioid use disorder treatment options in Madison, WI, this clinical trial (NCT04161066) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Madison research site is actively enrolling participants for this clinical trial. You'll receive care from experienced opioid use disorder specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all opioid use disorder clinical trials near you to find additional studies recruiting in your area.

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