Miami, FLNCT05865028Now EnrollingIRB Ready

Oropharyngeal Dysplasia Clinical Trial in Miami, FL

Access cutting-edge oropharyngeal dysplasia treatment through this clinical trial at a research site in Miami. Study-provided care at no cost to qualified participants.

Sponsored by Elizabeth J Franzmann

Quick Self-Assessment

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Expert Care in Miami

Access oropharyngeal dysplasia specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related oropharyngeal dysplasia treatment provided free

Apply for This Miami Location

Check if you qualify for this oropharyngeal dysplasia clinical trial in Miami, FL

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Miami

    Convenient for FL residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Miami site if eligible
  4. 4Begin participation

About This Oropharyngeal Dysplasia Study in Miami

The purpose of this study is to assess whether APG-157 can reduce the tumor size in participants with the study disease. Another purpose is to find out about the effects of APG-157 on certain tumor markers and oral rinses in participants with the study disease.

Sponsor: Elizabeth J Franzmann

Who Can Participate

Inclusion Criteria

Adult patients age \> 18 years with biopsy-proven moderate to severe oral dysplasia or carcinoma in situ (CIS) and a visible lesion. Sites include all oral cavity as well as oropharyngeal dysplasia that is accessible in the outpatient clinic.
Histologically proven oral cavity or oropharyngeal moderate or severe dysplasia/CIS as diagnosed by standard pathological methods and a visible lesion on oral exam.
Measurable disease - minimum lesion size of 8 x 3 mm before initial biopsy
Willing to provide blood, oral rinse and tissue from diagnostic biopsies
Leukocytes \>=3,000/microliter
Absolute neutrophil count \>= 1,000/microliter, Platelets \>= 100,000/microliter, Total bilirubin =\< 1.5 x institutional upper limit of normal (ULN), aspartate aminotransferase (AST), serum glutamic-oxaloacetic transaminase (SGOT), alanine aminotransferase (ALT) and serum glutamic pyruvic transaminase (SGPT) =\< 1.5 x institutional upper limit of normal (ULN). Exceptions to this Inclusion Criteria can be made if labs are deemed not clinically significant by the principal investigator (PI).
Willing to use adequate contraception, subject or partner has had a vasectomy or partner is using effective birth control or is post-menopausal for the duration of the study.
Able to take oral medication.
Able to understand and the willingness to sign a written informed consent document.

Exclusion Criteria

Pregnant women.
Subjects who have had surgery of the oral cavity, teeth, or gums within the previous 8 weeks excluding biopsies and tooth extractions.
Subjects who have had a fracture of the mandible or maxilla within the previous 8 weeks.
Inability to complete enrollment forms due to any mental status or language problems (e.g. dementia, head injury, overall illness).
History of prior head and neck squamous cell carcinomas (HNSCC) unless curatively treated 1 year or more prior.
Use of chemotherapy and/or radiation for any malignancy (excluding nonmelanoma skin cancer and cancer confined to organs with removal as only treatment) in the past 2 years.
Subjects with other related diseases or the oral cavity or oropharynx, as determined to be significant by the PI.
History of allergic reactions attributed to compounds of similar chemical composition to Curcumin (turmeric).
Active or chronic liver disease, evidence of hepatitis (infectious or autoimmune), cirrhosis or portal hypertension. Exceptions to this Exclusion Criteria can be made if patient status is deemed not clinically significant by the PI.
Severe thrombocytopenia increasing the risk of biopsy.
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, uncontrolled congestive heart failure, unstable angina pectoris, uncontrolled cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Miami?

Yes, this clinical trial (NCT05865028) has an active research site in Miami, FL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Oropharyngeal Dysplasia Treatment Options in Miami, FL

If you're searching for oropharyngeal dysplasia treatment options in Miami, FL, this clinical trial (NCT05865028) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Miami research site is actively enrolling participants for this clinical trial. You'll receive care from experienced oropharyngeal dysplasia specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all oropharyngeal dysplasia clinical trials near you to find additional studies recruiting in your area.

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