NCT07473713 · Tufts Medical Center
Veverimer to Decrease Net Acid Excretion and Bone Resorption in Adults With Osteopenia
What this study is about
The goal of this clinical trial is to learn if veverimer will reduce urinary net acid excretion leading to reduced bone resorption in healthy adults with osteopenia. The main questions it aims to answer are: * How much does each dose of veverimer (vs. placebo) reduce 24-hr urinary net acid excretion. * Describe the safety of veverimer based on changes in serum bicarbonate and potassium.
View original scientific description
The goal of this clinical trial is to learn if veverimer will reduce urinary net acid excretion leading to reduced bone resorption in healthy adults with osteopenia. The main questions it aims to answer are: * How much does each dose of veverimer (vs. placebo) reduce 24-hr urinary net acid excretion. * Describe the safety of veverimer based on changes in serum bicarbonate and potassium. * Assess the changes in bone resorption. * Assess the changes in bone formation. * Explore the effect of veverimer on physical performance.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Community dwelling adults age 50 years and older (approximately equal numbers of men and women).
- Men should be sterile or agree to use contraception throughout the study.
- Women must be postmenopausal, defined as no menses in the last 5 years (to reduce variability in change in bone resorption since menopause prompts a rapid increase in bone resorption).
- Osteopenia will be defined as a bone mineral density (BMD) T-score at the lumbar spine, femoral neck, or total hip lower than -1 or higher than -2.5.
- On a prescreening interview, candidates must report a usual diet associated with an acid load by our validated short questionnaire.
- Estimated glomerular filtration rate (eGFR) must be 45 ml/min or greater.
- Participants must agree not to change their exercise pattern or medication use during the study.
- Participants must agree not to change their pattern of supplement use and not to use antacids during the study because most calcium supplements and other antacids add alkali.
- Participants must agree to not change their eating habits or intentionally change their weight.
Exclusion criteria
- Normal BMD T-scores at all spine and hip sites, osteoporosis based on BMD T-score of -2.5 or less
- Respiratory illness in last month
- Chronic obstructive pulmonary disease (COPD)
- Nausea/vomiting in last month
- Malabsorption
- Inflammatory bowel disease
- Chronic diarrhea (defined as loose bowel movements daily) or constipation (≤ 2 stools per week)
- Insulin-requiring diabetes or fasting plasma glucose \>125 mg/dl
- Untreated thyroid disease
- Current unstable heart disease
- Malignancy (except non-melanoma skin cancer) or cancer therapy in last year
- Alcohol use \>2 drinks/day.
- Individuals who are unable to provide informed consent due to cognitive impairment.
Where
- Boston, Massachusetts
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Apr 6, 2026 · Source of record for eligibility and locations