University Park, PANCT07120997Now EnrollingIRB Ready

Perimenopausal Bone Loss Clinical Trial in University Park, PA

Access cutting-edge perimenopausal bone loss treatment through this clinical trial at a research site in University Park. Study-provided care at no cost to qualified participants.

Sponsored by Penn State University

Quick Self-Assessment

See if you qualify for this University Park location

Preparing your pre-screening questions…

Expert Care in University Park

Access perimenopausal bone loss specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related perimenopausal bone loss treatment provided free

Apply for This University Park Location

Check if you qualify for this perimenopausal bone loss clinical trial in University Park, PA

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to University Park

    Convenient for PA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit University Park site if eligible
  4. 4Begin participation

About This Perimenopausal Bone Loss Study in University Park

Dietary interventions of prune consumption during the transmenopausal period are innovative methods to prevent bone loss. Modern medicine does not intervene to prevent or attenuate this highly vulnerable period of bone loss which, if successfully attenuated, can potentially prevent/delay osteoporosis in women. The transmenopausal period represents an opportunistic window for the study because bone loss is at its greatest at this time, with females losing as much as 6-7% of bone. If this project is successful at attenuating bone loss, it can immediately be disseminated to the public to promote prune consumption to slow down and attenuate perimenopausal bone loss. As such, this project could improve the long-term bone health of females and avoid or delay osteoporosis and improve quality of life. The long-term goal of this study is to test the novel hypothesis that prune consumption for 18 months during the 3-year transmenopausal period prevents the dramatic rate of bone loss in perimenopausal females during a window of heightened physiological vulnerability. At Penn State University, the study will compare the effects of 18 months of daily dietary consumption of 50 g of prunes (5-6) versus a no-prune control group on bone outcomes (bone mineral density, bone geometry), mechanistic factors (bone and inflammatory markers, inflammatory response of ex vivo cultured peripheral blood mononuclear cells, monocytes), and gut microbiome.

Sponsor: Penn State University

Who Can Participate

Inclusion Criteria

Age 44 to 55 years
Not severely obese (BMI \<35 kg/m\^2)
Healthy (determined by a screening questionnaire, physical and medical history by a certified nurse practitioner, complete metabolic panel, and complete blood count)
Willing to include prunes in their daily diet
Not taking any natural dietary supplement containing phenolics, i.e.,\< 1 cup/day of blueberries or apples for at least 2 months prior to study entry
Non-smoking
No menses for ≥60 days but not more than 18 months post final menstrual period
Only participants who have a determinable natural (not surgical) final menstrual period date are eligible

Exclusion Criteria

Subjects who regularly consume prunes, dried apples, prune juice, or heavy consumers of blueberries (1 cup or more/day)
History of vertebral fracture or fragility fracture of the wrist, humerus, hip or pelvis after age 45 yr)
Untreated hyper- or hypothyroidism
Current hyper- or hypoparathyroidism
Significantly impaired renal function
Current hypo- or hypercalcemia
History of spinal stenosis
History of heart attack, stroke, thromboembolism, kidney disease, malabsorption syndrome, or seizure disorders
Positive for HIV, Hep-C or Hep-B surface antigen and malignancy
Use of the following agents affecting bone metabolism: intravenous bisphosphonates at any time; fluoride (for osteoporosis) within the past 24 months; denosumab at any time; bisphosphonates, parathyroid hormone or strontium within the past 12 months; calcitonin; selective estrogen receptor modulators within the past 12 months; systemic oral or transdermal estrogen within the past 3 months; systemic glucocorticosteroids (≥ 5 mg prednisone equivalent per day for more than 10 days); or tibolone within the past 3 months
Hormonal contraception within the past three months
Subjects who will not consume study provided dietary items or who will not stop taking their own natural product supplements

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in University Park?

Yes, this clinical trial (NCT07120997) has an active research site in University Park, PA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Perimenopausal Bone Loss Treatment Options in University Park, PA

If you're searching for perimenopausal bone loss treatment options in University Park, PA, this clinical trial (NCT07120997) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our University Park research site is actively enrolling participants for this clinical trial. You'll receive care from experienced perimenopausal bone loss specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all perimenopausal bone loss clinical trials near you to find additional studies recruiting in your area.

More Pulmonary Embolism Trials in University Park, PA

See all pulmonary embolism clinical trials recruiting in University Park — not just this study.

Browse Pulmonary Embolism Trials in University Park

Ready to Join in University Park?

Take the first step toward participating in this groundbreaking clinical trial

Secure · Expert Care · University Park, PA