NCT07365514 · University of Connecticut
Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal Females
What this study is about
The goal of this clinical trial is to evaluate the effects of blackcurrant (BC) supplementation on changes in bone density and gut microbiome composition in postmenopausal females.
View original scientific description
The goal of this clinical trial is to evaluate the effects of blackcurrant (BC) supplementation on changes in bone density and gut microbiome composition in postmenopausal females.
Interventions
DRUG
Blackcurrant (BC) extract
Consume three capsules per day containing 784 mg of blackcurrant (BC) extract (261.33 mg BC and 130.67 mg placebo per capsule)
DRUG
Blackcurrant (BC) extract
Consume three capsules containing 1,176 mg BC of extract (392 mg BC per capsule)
DRUG
Placebo
Consume three placebo capsules (392 mg placebo per capsule)
Primary outcome measures
Bone Mineral Density (BMD)
Time frame: From baseline to months 6 and 12
Changes from baseline in whole-body, lumbar spine, total hip and femoral neck BMD at months 6 and 12 measured via dual energy x-ray absorptiometry (DXA)
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- postmenopausal (defined as no more than 10 years since final menstrual cycle) females aged 45-70 years
- not on hormone replacement therapy for at least one year before initiation of the study
- maintaining normal exercise level (\< 7 hours/week) and willing to avoid exercise for 24 hours prior to blood and stool sampling
- willing to ingest a dietary blackcurrant supplement or placebo (up to 1,176 mg/day, three 392mg capsules)
- willing to avoid other dietary supplements for the duration of the study
- willing to avoid intake of foods extremely rich in anthocyanins and fermented dairy products containing viable Bifidobacteria or Lactobacilli
- willing to have three blood draws, three stool collections, and three bone scans
Exclusion criteria
- history of cardiovascular disease, osteoporosis, metabolic bone disease, cancer, diabetes mellitus, arthritis, or other chronic inflammatory diseases
- current smokers
- taking prescription medications known to alter bone and calcium metabolism
- taking anabolic agents such as parathyroid hormone or growth hormone, or steroid within 3 months before the start of the study
- taking medications that alter bleeding (such as antiplatelets or anticoagulants) or those with a bleeding disorder
- alcohol consumption exceeding 2 drinks/day (approximately 14g of ethanol per drink) or a total of 12/week
- those with planned surgery during the study period or within 2 weeks of ending the intervention
- those with sensitivities or allergies to any of the ingredients for the placebo (rice powder)
- planning a procedure that includes iodine, barium or nuclear medicine isotopes within the study period
- UConn students and/or employees who any key personnel teach or who report to any key personnel
- study key personnel, partners of key personnel, or dependents/relatives of any key personnel
Where
- Storrs, Connecticut
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jul 23, 2026 · Source of record for eligibility and locations