Cleveland, OHNCT03541889Now EnrollingIRB Ready

Primary Graft Failure Clinical Trial in Cleveland, OH

Access cutting-edge primary graft failure treatment through this clinical trial at a research site in Cleveland. Study-provided care at no cost to qualified participants.

Sponsored by University of Oklahoma

Quick Self-Assessment

See if you qualify for this Cleveland location

Preparing your pre-screening questions…

Expert Care in Cleveland

Access primary graft failure specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related primary graft failure treatment provided free

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Check if you qualify for this primary graft failure clinical trial in Cleveland, OH

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Cleveland

    Convenient for OH residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Cleveland site if eligible
  4. 4Begin participation

About This Primary Graft Failure Study in Cleveland

The purpose of this study is to find new tests that could help determine if the newly infused bone marrow cells are growing well after bone marrow transplantation or if new bone marrow cells are needed. The Investigator will use FLT imaging, an investigational imaging test, and collect blood samples to investigate whether the cells are growing well.

Sponsor: University of Oklahoma

Who Can Participate

Inclusion Criteria

Ability to undergo 18F FLT imaging without sedation
Patients \> 4 years of age and less than 80 years of age at highest risk for graft failure: cord blood HSCT, haplo HSCT, or lack of engraftment by day 28.
Diagnosed with a condition for which hematopoietic stem cell transplant (HSCT) is standard of care and HSCT is planned (Arm A) or occurred (Arm B)
In morphologic remission prior to HSCT
Patient or guardian able to give informed consent
Investigational therapies within past 28 days or planned on protocol are pre-approved by the PI or Site PI
Karnofsky or Lansky performance status \> 60% Arm A
A1 Cord blood recipients: Absence of donor specific antibodies to cord HLA
Haplo-identical recipients: ≥ 5/10 and \< 7/8 allele mismatch donor
A2- myeloablative Haplo-identical transplant is planned
A3- reduced intensity Haplo-identical transplant is planned (non-myeloablative is excluded)
A1- myeloablative or reduced intensity transplant is planned (non-myeloablative is excluded)
Diagnosed with a condition for which hematopoietic stem cell transplant (HSCT) is standard of care and HSCT is planned
Total bilirubin \< 2.5 mg/dL (unless documented Gilbert's syndrome) and transaminases (ALT and AST) \< 5 x the upper limit of normal
Creatinine clearance or GFR \> 60 ml/min/1.73 m2. (performed pre-HSCT)
FEV1 \> 80% pre or post-bronchiolator whichever is higher and DLCO Adj \> 70% (performed pre-HSCT if age appropriate) and Sa02 \> 94% on room air
Ejection fraction \> 50% (performed pre-HSCT) Arm B • Non-engraftment recipients of HCT with any donor source (related or unrelated): primary graft failure as defined by ANC not \> 500 for 3 consecutive days and at least 20 days after HSCT. Inclusion Criteria - Donors
1-2 cords and \>.4/6 match to recipient for each (as per current National Marrow Donor guidelines), with a dose \>2 x 10e6 CD34 cells/kg for each cord OR \> 5/10 and \<7/8 allele mismatch related donor
Institutional guidelines met for donor suitability

Exclusion Criteria

History of psychiatric disorder which may compromise compliance with transplant protocol, or which does not allow for appropriate informed consent
Clinically significant systemic illness with manifestations of significant organ dysfunction which, in the judgment of the PI, or Co-I, would render the patient unlikely to tolerate the protocol therapy or complete the study
Presence of active malignancy from an organ system other than hematopoietic
Pregnant or lactating females
Patients who are unable or unwilling to use effective form (s) of contraception during the course of the study
Prior history of fluorothymidine allergy or intolerance
Decline enrolment on CIBMTR research protocol

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Cleveland?

Yes, this clinical trial (NCT03541889) has an active research site in Cleveland, OH that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Primary Graft Failure Treatment Options in Cleveland, OH

If you're searching for primary graft failure treatment options in Cleveland, OH, this clinical trial (NCT03541889) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Cleveland research site is actively enrolling participants for this clinical trial. You'll receive care from experienced primary graft failure specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all primary graft failure clinical trials near you to find additional studies recruiting in your area.

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