Houston, TXNCT07475780Now EnrollingIRB Ready

Recurrent Parathyroid Carcinoma Clinical Trial in Houston, TX

Access cutting-edge recurrent parathyroid carcinoma treatment through this clinical trial at a research site in Houston. Study-provided care at no cost to qualified participants.

Sponsored by M.D. Anderson Cancer Center

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Expert Care in Houston

Access recurrent parathyroid carcinoma specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related recurrent parathyroid carcinoma treatment provided free

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Check if you qualify for this recurrent parathyroid carcinoma clinical trial in Houston, TX

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Why Participate?

  • No-Cost Study Care

  • Local to Houston

    Convenient for TX residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Houston site if eligible
  4. 4Begin participation

About This Recurrent Parathyroid Carcinoma Study in Houston

The study will be an effectiveness study. The study will include enrollment of a total of 20 patients with at least one PC lesion for ultrasound guided RFA to PC recurrence in the neck to assess the effectiveness in reducing patient's hypercalcemia. Patients will have surgically proven PC from prior parathyroidectomy and suspicious PC visible on ultrasound and request for treatment for uncontrolled hypercalcemia (Figure 1).

Sponsor: M.D. Anderson Cancer Center

Who Can Participate

Inclusion Criteria

Adult patients with recurrent parathyroid carcinoma that was previously resected and persistent or recurrent hypercalciemia. Patients are not surgical candidates or strongly desire nonsurgical intervention. Eligibility for enrollment will be based upon meeting inclusion and

Exclusion Criteria

as detailed in section 4.1 and 4.2. The study will include 20 eligible patients or lesions. Utmost care will be taken to minimize risk to patients through careful selection of patients and scheduled assessments (Table 1). Patients will be recruited through the Endocrine, Endocrine surgery, Head and Neck Surgery Clinics, as well as Neuro-Interventional Radiology Ultrasound. All patients who meet the inclusion and exclusion criteria and agree to participate in the study will be consented and then enrolled into the study. No other criteria, apart from the eligibility criteria detailed below, will be used for subject selection. We anticipate enrolling approximately 1 patient every 2 months (0.5 patients/month), for a total accrual period of up to 40 months to reach the planned sample size of 20 patients. Each participant will be followed for 12 months after RFA, so the total study duration is estimated at approximately 52 months from first patient enrollment to last patient follow-up. Candidates for this study must meet all of the following inclusion criteria:
Patient is older than 18 years, is not a surgical candidate or refuses to have surgery.
Patient is medically fit to undergo local anesthesia with or without conscious sedation.
Patient is able to understand and give consent to participation in the study.
Confirmed parathyroid carcinoma by prior surgery and histopathology.
Presence of local recurrence or implant in the neck visible on ultrasound.
Distant oligometastasis visible on ultrasound.
Solid nodule without macrocalcification or internal cystic degeneration
Patient who is off of Cinacalcet
Entirety of the selected nodule is visible on ultrasound without significant extension posterior to trachea or mediastinal component (ie Type A, E, or high F).
Selected nodule is amenable to medial or lateral approach.
Normal complete blood count, blood coagulation.
Patient agrees to participate in the clinical study and to complete all required visits and evaluations.
Negative serum or urine pregnancy test for females of childbearing potential at baseline pre-procedure evaluation. Exclusion Criteria: Candidates will be ineligible for enrollment in the study if any of the following conditions apply:
Patients with cardiac arrhythmia and/or implanted cardiac device
Surgically naïve parathyroid lesions, parathyroid adenoma or atypical parathyroid tumor.
Allergies to medications for anesthesia.
Cystic nodules (\< 70% solid components)
Calcified nodules
Targeted nodule within 0.5 cm from the major vessels, vagus nerve, brachial plexus, and recurrent laryngeal nerve.
Patients with contralateral vocal cord paralysis.
Uncorrectable coagulopathy with PTT\>1.5 X ULN or INR \>1.5 or platelet count \<100,000 per mm3

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Houston?

Yes, this clinical trial (NCT07475780) has an active research site in Houston, TX that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Recurrent Parathyroid Carcinoma Treatment Options in Houston, TX

If you're searching for recurrent parathyroid carcinoma treatment options in Houston, TX, this clinical trial (NCT07475780) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Houston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced recurrent parathyroid carcinoma specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all recurrent parathyroid carcinoma clinical trials near you to find additional studies recruiting in your area.

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