Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer
This phase III trial compares the effect of cabozantinib versus combination dabrafenib and trametinib for the treatment of patients with differentiated thyroid cancer that does not respond to treatmen...
Lenvatinib in Locally Advanced Invasive Thyroid Cancer
This research is being done to evaluate the safety and efficacy of neoadjuvant lenvatinib on surgical outcomes of patients with invasive extrathyroidal differentiated thyroid cancer (DTC). This resea...
Restor. I-131 Upt. + Selpercatinib in RET F-P RAI-R TC
This research is being done to determine the efficacy of selpercatinib to restore radioactive iodine (I-131 NaI) uptake and allow for I-131 treatment in people with RET fusion-positive radioiodine-ref...
A Study of Avutometinib and Defactinib in People With Thyroid Cancer
The researchers are doing this study to find out if the combination of avutometinib and defactinib is an effective treatment for RAF dimer-driven radioiodine-refractory differentiated thyroid cancer o...
Larotrectinib to Enhance RAI Avidity in Differentiated Thyroid Cancer
Papillary thyroid cancer (PTC) is the most common form of differentiated thyroid cancer (DTC). The traditional first line treatment for patients with advanced DTC after surgical resection is radioacti...
Top Cities for Thyroid Cancer Clinical Trials
Thyroid Cancer clinical trials are recruiting across 26 cities. Here are the cities with the most active studies:
About Thyroid Cancer
Thyroid cancer develops in the thyroid gland and is the most common endocrine malignancy. Most thyroid cancers are highly treatable with excellent prognosis. Types include papillary, follicular, medullary, and anaplastic thyroid cancer.
Clinical trials are advancing new treatments for thyroid cancer. Currently, 5 studies are recruiting a combined 367 participants across the United States. Research is being conducted by 5 organizations including ECOG-ACRIN Cancer Research Group, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital and 2 others.
2026 Thyroid Cancer Research Landscape
As of March 2026, the thyroid cancer clinical trial landscape includes 5 actively recruiting studies across 26 cities in the United States. These studies are collectively seeking 367 participants, with an average enrollment target of 73 per study.
Research is being led by 5 different organizations, including ECOG-ACRIN Cancer Research Group, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital, Memorial Sloan Kettering Cancer Center, Children's Hospital of Philadelphia.
Geographically, thyroid cancer trials are most concentrated in Houston, Texas (3 trials); New Haven, Connecticut (2 trials); Boston, Massachusetts (2 trials); New York, New York (2 trials); Philadelphia, Pennsylvania (2 trials) and 7 other cities.
Featured Thyroid Cancer Studies
Highlighted recruiting studies for thyroid cancer, selected by enrollment size and research scope.
Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer
This phase III trial compares the effect of cabozantinib versus combination dabrafenib and trametinib for the treatment of patients with differentiated thyroid cancer that does not respond to treatment (refractory) and which expresses a BRAF V600E mutation. Cabozantinib is in a class of medications called receptor tyrosine kinase inhibitors. It binds to and blocks the action of several enzymes whi...
Lenvatinib in Locally Advanced Invasive Thyroid Cancer
This research is being done to evaluate the safety and efficacy of neoadjuvant lenvatinib on surgical outcomes of patients with invasive extrathyroidal differentiated thyroid cancer (DTC). This research study involves a study drug called lenvatinib
Restor. I-131 Upt. + Selpercatinib in RET F-P RAI-R TC
This research is being done to determine the efficacy of selpercatinib to restore radioactive iodine (I-131 NaI) uptake and allow for I-131 treatment in people with RET fusion-positive radioiodine-refractory thyroid cancer. This research study involves the study drug selpercatinib in combination with standard of care treatments, I-131 and thyrotropin alfa (rhTSH).
Frequently Asked Questions About Thyroid Cancer Clinical Trials
Are there thyroid cancer clinical trials near me?
Yes, there are 5 thyroid cancer clinical trials currently recruiting across 26+ cities in the United States, including Houston, Texas; New Haven, Connecticut; Boston, Massachusetts. Browse the studies above to find one at a location convenient for you.
How do I join a thyroid cancer clinical trial?
To join a thyroid cancer clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are thyroid cancer clinical trials free?
Yes, participation in thyroid cancer clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of thyroid cancer treatments are being studied?
Current thyroid cancer clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 5 research organizations.
Is it safe to participate in thyroid cancer clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 1, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 1, 2026 · Data from ClinicalTrials.gov