Memphis, TNNCT07257419Now EnrollingIRB Ready

Relapsed Pediatric ALL Clinical Trial in Memphis, TN

Access cutting-edge relapsed pediatric all treatment through this phase 1 clinical trial at a research site in Memphis. Study-provided care at no cost to qualified participants.

Sponsored by St. Jude Children's Research Hospital

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Expert Care in Memphis

Access relapsed pediatric all specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related relapsed pediatric all treatment provided free

Apply for This Memphis Location

Check if you qualify for this relapsed pediatric all clinical trial in Memphis, TN

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Memphis

    Convenient for TN residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Memphis site if eligible
  4. 4Begin participation

About This Relapsed Pediatric ALL Study in Memphis

The purpose of this study is to learn more about newer methods of transplanting blood cells donated by a partially matched family member to children with high-risk CD19 positive leukemia ALL. Primary Objective: \- To assess the safety and feasibility of combining CD19-CAR(Mem) T cells after TCRαβ+/CD19 depleted haploidentical donor transplantation for pediatric patients with relapsed/refractory CD19+ B-cell malignancies. Secondary Objectives: * To estimate 1-year post-transplant overall survival, event-free survival, and GVHD-free relapse-free survival (GRFS). * To estimate cumulative incidence of engraftment, acute and chronic GVHD, and immune-related adverse events, including CRS and ICANS.

Sponsor: St. Jude Children's Research Hospital

Who Can Participate

Inclusion Criteria

Age less than or equal to 21 years
High risk hematologic malignancy where allogeneic transplantation is the current standard of care. This includes (but is not limited to):
High risk CD19+ B cell ALL in CR1 or CR2
Any CD19+ B-cell ALL in CR3 or subsequent
If prior CNS leukemia, it must be treated and in CNS CR
Left ventricular ejection fraction \> 40%, or shortening fraction ≥ 25%
Creatinine clearance (CrCl) or glomerular filtration rate (GFR) ≥ 50 ml/min/1.73m2
Forced vital capacity (FVC) ≥ 50% of predicted value; or pulse oximetry ≥ 92% on room air if patient is unable to perform pulmonary function testing
Karnofsky or Lansky (age dependent) performance score ≥ 50 (See APPENDIX A)
Bilirubin ≤ 3 times the upper limit of normal for age
Alanine aminotransferase (ALT) or Aspartate aminotransferase (AST) ≤ 5 times the upper limit of normal for age Donor
At least single haplotype matched (≥ 4 of 8) family member
At least 18 years of age
HIV negative
If sexually active, agreement to use birth control until 2 weeks after completion of the mobilization and apheresis procedure
Regarding donation eligibility, is identified as either:
Completed the process of donor eligibility determination as outlined in 21 CFR 1271 and agency guidance; OR
Does not meet 21 CFR 1271 eligibility requirements, but has a declaration of urgent medical need completed by the principal investigator or physician sub-investigator per 21 CFR 1271

Exclusion Criteria

Has a suitable HLA-identical sibling or suitable 12/12 (HLA-A, B, C, DRB1, DQB1, and DPB1) HLA-matched unrelated donor available in an appropriate time frame
Any other active malignancy other than the one for which this HCT is indicated
Received a prior allogeneic HCT at any time
Pregnant, if female is of childbearing potential, negative test must be confirmed by serum or urine pregnancy test within 14 days prior to enrollment
If sexually active, agreement to use birth control until 6 months after T cell infusion
Breast feeding
Any severe current uncontrolled bacterial, fungal or viral infection Donor
Pregnant, negative test must be confirmed by serum or urine pregnancy test within 14 days prior to enrollment if female
If female, breast feeding

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Memphis?

Yes, this clinical trial (NCT07257419) has an active research site in Memphis, TN that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Relapsed Pediatric ALL Treatment Options in Memphis, TN

If you're searching for relapsed pediatric all treatment options in Memphis, TN, this clinical trial (NCT07257419) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Memphis research site is actively enrolling participants for this phase 1 clinical trial. You'll receive care from experienced relapsed pediatric all specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all relapsed pediatric all clinical trials near you to find additional studies recruiting in your area.

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