Philadelphia, PANCT05437705Now EnrollingIRB Ready

Rumination Clinical Trial in Philadelphia, PA

Access cutting-edge rumination treatment through this clinical trial at a research site in Philadelphia. Study-provided care at no cost to qualified participants.

Sponsored by University of Pennsylvania

Quick Self-Assessment

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Expert Care in Philadelphia

Access rumination specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related rumination treatment provided free

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Check if you qualify for this rumination clinical trial in Philadelphia, PA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Philadelphia

    Convenient for PA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Philadelphia site if eligible
  4. 4Begin participation

About This Rumination Study in Philadelphia

The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation (TMS). First, the investigators will use functional Magnetic Resonance Imaging (fMRI) data to generate a negative affect map for each participant. Then, the investigators will apply a variety of repetitive transcranial magnetic stimulation (rTMS) sequences while the participant is inside the MRI scanner to determine the optimal and least optimal rTMS frequencies at changing negative affect brain states. Finally, these two frequencies will be tested over two 3-day rTMS neuromodulation sessions to assess whether they can reduce negative emotions.

Sponsor: University of Pennsylvania

Who Can Participate

Inclusion Criteria

18-65 years old
Patient Health Questionnaire (PHQ-9 score) = or \> than 10
Comprehension of instructions in the English language.
Capacity to provide informed consent and follow study procedures.
Availability for the duration of the study.

Exclusion Criteria

Diagnosis of bipolar disorder (as PI discretion), schizophrenia or other psychotic disorder
Recent use of psychoactive medications or substances as determined by investigators
History of neurological disorder or traumatic brain injury (other than mild)
Unable to have an MRI scan, or current or prior medical condition that could interfere with the collection or interpretation of MRI data
Unable to receive or tolerate TMS
Implanted devices, such as an aneurysm clip or cardiac pacemaker
History of stroke, epilepsy, or brain scarring
Pregnant, nursing, or trying to become pregnant (self-attestation alone) During this study, participants are asked to:
Refrain from substance use (including marijuana and illicit drugs) for duration of the study (self-attestation alone).
Abstain from alcohol for 24 hours before the MRI scans (self-attestation alone).
Abstain from increasing caffeine intake or begin taking any new medications (self-attestation alone).

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Philadelphia?

Yes, this clinical trial (NCT05437705) has an active research site in Philadelphia, PA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Rumination Treatment Options in Philadelphia, PA

If you're searching for rumination treatment options in Philadelphia, PA, this clinical trial (NCT05437705) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Philadelphia research site is actively enrolling participants for this clinical trial. You'll receive care from experienced rumination specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all rumination clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Philadelphia, PA