Detroit, MINCT07210606Now EnrollingIRB Ready

Sleep Disordered Breathing Clinical Trial in Detroit, MI

Access cutting-edge sleep disordered breathing treatment through this phase 4 clinical trial at a research site in Detroit. Study-provided care at no cost to qualified participants.

Sponsored by VA Office of Research and Development

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Expert Care in Detroit

Access sleep disordered breathing specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related sleep disordered breathing treatment provided free

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Check if you qualify for this sleep disordered breathing clinical trial in Detroit, MI

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Why Participate?

  • No-Cost Study Care

  • Local to Detroit

    Convenient for MI residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Detroit site if eligible
  4. 4Begin participation

About This Sleep Disordered Breathing Study in Detroit

Central sleep apnea (CSA) is common in patients with heart failure and those using opioid analgesics. Unfortunately, effective treatment of central apnea remains elusive, pressure therapy given the modest efficiency of positive airway pressure therapy. The focus of this proposal is to identify mechanistic pathways to guide future therapeutic interventions for central sleep apnea based on the strong premise that multi-modality therapy will normalize respiration and hence mitigate adverse long-term consequences of CSA. The investigators' proposed studies will test combination therapies, including positive airway pressure (PAP) plus a pharmacological agent who have heart failure or are using opioid analgesics. The investigators anticipate that findings will inform future clinical trials to improve care and quality of life among Veterans suffering from central sleep apnea, which remains difficult to treat using existing approaches.

Sponsor: VA Office of Research and Development

Who Can Participate

Inclusion Criteria

Men and women Veterans with central sleep apnea, defined as Apnea Hypopnea Index (AHI)\>15/hour with CAHI\>5/hour, will be included with the experiments
Those with chronic, stable heart failure with reduced ejection fraction, receiving stable optimized guideline-based therapy and no hospitalizations or change in the medical regimen for the past 90 days before enrollment

Exclusion Criteria

Pregnant or breastfeeding females
Moderate or severe obstructive or restrictive lung disease, including supplemental oxygen (O2) use
Current treatment for central sleep apnea (CSA), including any form of positive airway pressure (PAP) in the past three months, or phrenic nerve situation
Too ill to engage in the study procedures, inability to provide consent for participation
A history of cardiac arrhythmia
Alcohol or substance abuse (less than 90 days sobriety) or current participation in a treatment program
Depression or a history of suicidality
Severe insomnia (ISI\>21) or reported short sleep duration (\<6 hours)
Positive airway pressure (PAP)-emergent central sleep apnea
Lack of positive airway pressure (PAP) acceptance/adherence after a one-week home PAP trial after enrollment Additional Trazodone Exclusions:
Prolonged QT on baseline electrocardiogram (ECG), using medications that inhibit CYP3A4
Patients with severe renal impairment (glomerular filtration rate (GFR) \< 20 milliliters per minute/1.73 square meters) or end-stage renal disease

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Detroit?

Yes, this clinical trial (NCT07210606) has an active research site in Detroit, MI that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Sleep Disordered Breathing Treatment Options in Detroit, MI

If you're searching for sleep disordered breathing treatment options in Detroit, MI, this clinical trial (NCT07210606) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Detroit research site is actively enrolling participants for this phase 4 clinical trial. You'll receive care from experienced sleep disordered breathing specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all sleep disordered breathing clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Detroit, MI