Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Chronic Fatigue Syndrome Clinical Trials
Chronic Fatigue Syndrome clinical trials are recruiting across 5 cities. Here are the cities with the most active studies:
Chronic Fatigue Syndrome Trial Phases
5 research organizations are sponsoring chronic fatigue syndrome trials.
About Chronic Fatigue Syndrome
Chronic fatigue syndrome (ME/CFS) is a complex, debilitating condition characterized by extreme fatigue that is not improved by rest and worsened by physical or mental activity. It affects millions worldwide, with no definitive diagnostic test. Treatment focuses on symptom management and pacing strategies.
Clinical trials are advancing new treatments for chronic fatigue syndrome. Currently, 5 studies are recruiting a combined 630 participants across the United States. Research is being conducted by 5 organizations including University of California, San Francisco, Brigham and Women's Hospital, Icahn School of Medicine at Mount Sinai and 2 others.
2026 Chronic Fatigue Syndrome Research Landscape
As of July 2026, the chronic fatigue syndrome clinical trial landscape includes 5 actively recruiting studies across 5 cities in the United States. These studies are collectively seeking 630 participants, with an average enrollment target of 126 per study.
The research spans multiple phases of development: 3 studies are in PHASE2, 1 study is in PHASE1, 1 study is in NA. Early-phase studies suggest new therapeutic approaches are being explored for chronic fatigue syndrome.
Research is being led by 5 different organizations, including University of California, San Francisco, Brigham and Women's Hospital, Icahn School of Medicine at Mount Sinai, Nova Southeastern University, Stony Brook University.
Geographically, chronic fatigue syndrome trials are most concentrated in San Francisco, California (1 trial); Boston, Massachusetts (1 trial); New York, New York (1 trial); Fort Lauderdale, Florida (1 trial); Stony Brook, New York (1 trial).
Featured Chronic Fatigue Syndrome Studies
Highlighted recruiting studies for chronic fatigue syndrome, selected by enrollment size and research scope.
Chronic Infections and Inflammation in ME/CFS: An Observational Study
CHIIME is a study of people who have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). People who do not have this condition will also be enrolled. Volunteers will be observed and sampled over time to identify the long-terms biological drivers and impact of their condition. The overall goal is to understand the biological and physiological mechanisms that are driving this condition.
LIFT: Life Improvement Trial
The LIFT will be conducted at Brigham and Women's Hospital (BWH) of Harvard Medical School, focusing on the effect of Pyridostigmine (Mestinon) and Low-Dose Naltrexone (LDN) in subjects aged 18-70 meeting the Canadian consensus criteria (CCC) for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) as well as having specifically Orthostatic Intolerance (OI). Long COVID (LC) subjects will al...
Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This will be a pilot multi-arm clinical trial investigating the feasibility of Lumbrokinase (LK) as an intervention in three clinical cohorts: * Long Covid (LC) * Post-treatment Lyme disease syndrome (PTLDS) * Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Frequently Asked Questions About Chronic Fatigue Syndrome Clinical Trials
Are there chronic fatigue syndrome clinical trials near me?
Yes, there are 5 chronic fatigue syndrome clinical trials currently recruiting across 5+ cities in the United States, including San Francisco, California; Boston, Massachusetts; New York, New York. Browse the studies above to find one at a location convenient for you.
How do I join a chronic fatigue syndrome clinical trial?
To join a chronic fatigue syndrome clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are chronic fatigue syndrome clinical trials free?
Yes, participation in chronic fatigue syndrome clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of chronic fatigue syndrome treatments are being studied?
Current chronic fatigue syndrome clinical trials are testing a range of approaches across PHASE2 (3 studies), PHASE1 (1 study), NA (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 5 research organizations.
Is it safe to participate in chronic fatigue syndrome clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 16, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 16, 2026 · Data from ClinicalTrials.gov