Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible t...
Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial
This trial is being completed to compare two commonly used options to treat pain after discharge from surgery. Participants that undergo tonsil removal, gallbladder removal, and knee scope will be eli...
REmotely-delivered Supportive Programs for Improving Surgical Pain and disTrEss
The purpose of this research study is to learn how two different supportive programs may help women feel better after surgery. This study will measure if one type of supportive program is more useful ...
Intraperitoneal Infusion of Analgesic for Postoperative Pain Management
The study is a prospective, double-blinded, placebo-controlled multi-center trial to measure if postoperative pain and the amount of narcotics used are reduced by a clinically significant amount in wo...
A Study on TLC590 for Managing Postsurgical Pain
This Phase 2 open-label trial investigates the pharmacokinetics (PK), pharmacodynamics, and safety profile of TLC590 across various surgical procedures. Researchers aim to determine the maximum tolera...
Top Cities for Post-Surgical Pain Clinical Trials
Post-Surgical Pain clinical trials are recruiting across 15 cities. Here are the cities with the most active studies:
About Post-Surgical Pain
Post-surgical pain is a common experience after any surgical procedure, ranging from mild discomfort to severe pain. Effective pain management is critical for recovery and prevention of chronic post-surgical pain. Treatment includes multimodal approaches combining non-opioid analgesics, regional anesthesia, and rehabilitation.
Clinical trials are advancing new treatments for post-surgical pain. Currently, 5 studies are recruiting a combined 2,200 participants across the United States. Research is being conducted by 4 organizations including University of Michigan, Wake Forest University Health Sciences, Ying Liu and 1 others.
2026 Post-Surgical Pain Research Landscape
As of March 2026, the post-surgical pain clinical trial landscape includes 5 actively recruiting studies across 15 cities in the United States. These studies are collectively seeking 2,200 participants, with an average enrollment target of 440 per study.
Research is being led by 4 different organizations, including University of Michigan, Wake Forest University Health Sciences, Ying Liu, Taiwan Liposome Company.
Geographically, post-surgical pain trials are most concentrated in Ann Arbor, Michigan (2 trials); Toronto, Ontario (2 trials); Washington D.C., District of Columbia (2 trials); Detroit, Michigan (1 trial); St Louis, Missouri (1 trial) and 7 other cities.
Featured Post-Surgical Pain Studies
Highlighted recruiting studies for post-surgical pain, selected by enrollment size and research scope.
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll. Eligible participants will be randomized to 1 of 2 groups of medications (Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) plus acetaminophen or low dose opioids plus acetaminophen). It is an...
Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial
This trial is being completed to compare two commonly used options to treat pain after discharge from surgery. Participants that undergo tonsil removal, gallbladder removal, and knee scope will be eligible to enroll. Eligible participants will be randomized to prescription of 1 of 2 groups of medications (Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) plus acetaminophen or low dose opioids with th...
REmotely-delivered Supportive Programs for Improving Surgical Pain and disTrEss
The purpose of this research study is to learn how two different supportive programs may help women feel better after surgery. This study will measure if one type of supportive program is more useful than the other for improving wellbeing after surgery.
Frequently Asked Questions About Post-Surgical Pain Clinical Trials
Are there post-surgical pain clinical trials near me?
Yes, there are 5 post-surgical pain clinical trials currently recruiting across 15+ cities in the United States, including Ann Arbor, Michigan; Toronto, Ontario; Washington D.C., District of Columbia. Browse the studies above to find one at a location convenient for you.
How do I join a post-surgical pain clinical trial?
To join a post-surgical pain clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are post-surgical pain clinical trials free?
Yes, participation in post-surgical pain clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of post-surgical pain treatments are being studied?
Current post-surgical pain clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 4 research organizations.
Is it safe to participate in post-surgical pain clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 1, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 1, 2026 · Data from ClinicalTrials.gov