Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Post-Surgical Pain Clinical Trials
Post-Surgical Pain clinical trials are recruiting across 38 cities. Here are the cities with the most active studies:
Post-Surgical Pain Trial Phases
27 research organizations are sponsoring post-surgical pain trials.
About Post-Surgical Pain
Post-surgical pain is a common experience after any surgical procedure, ranging from mild discomfort to severe pain. Effective pain management is critical for recovery and prevention of chronic post-surgical pain. Treatment includes multimodal approaches combining non-opioid analgesics, regional anesthesia, and rehabilitation.
Clinical trials are advancing new treatments for post-surgical pain. Currently, 32 studies are recruiting a combined 10,215 participants across the United States. Research is being conducted by 27 organizations including Telethon Kids Institute, University of Michigan, Ensysce Biosciences and 24 others.
2026 Post-Surgical Pain Research Landscape
As of July 2026, the post-surgical pain clinical trial landscape includes 32 actively recruiting studies across 38 cities in the United States. These studies are collectively seeking 10,215 participants, with an average enrollment target of 319 per study.
The research spans multiple phases of development: 13 studies are in NA, 7 studies are in PHASE4, 6 studies are in PHASE2, 3 studies are in PHASE1, 2 studies are in PHASE3. The presence of Phase 3 trials indicates that some post-surgical pain treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 27 different organizations, including Telethon Kids Institute, University of Michigan, Ensysce Biosciences, University of Oklahoma, Johns Hopkins University, and 22 others. The large number of sponsors reflects significant research interest and investment in post-surgical pain treatment advancement.
Geographically, post-surgical pain trials are most concentrated in Boston, Massachusetts (5 trials); Houston, Texas (4 trials); Ann Arbor, Michigan (3 trials); St Louis, Missouri (3 trials); Los Angeles, California (3 trials) and 7 other cities.
Featured Post-Surgical Pain Studies
Highlighted recruiting studies for post-surgical pain, selected by enrollment size and research scope.
A Longitudinal Study Looking at the Prevalence, Risk Factors & Consequences of Persistent Post-surgical Pain in Children
The purpose of this study is to investigate the prevalence, risk factors and consequences of chronic post-surgical pain in children aged 0-16 years through a number of questionnaires completed at various timepoints, from before surgery up to 1 year post surgery.
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll. Eligible participants will be randomized to 1 of 2 groups of medications (Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) plus acetaminophen or low dose opioids plus acetaminophen). It is an...
Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial
This trial is being completed to compare two commonly used options to treat pain after discharge from surgery. Participants that undergo tonsil removal, gallbladder removal, and knee scope will be eligible to enroll. Eligible participants will be randomized to prescription of 1 of 2 groups of medications (Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) plus acetaminophen or low dose opioids with th...
Frequently Asked Questions About Post-Surgical Pain Clinical Trials
Are there post-surgical pain clinical trials near me?
Yes, there are 32 post-surgical pain clinical trials currently recruiting across 38+ cities in the United States, including Boston, Massachusetts; Houston, Texas; Ann Arbor, Michigan. Browse the studies above to find one at a location convenient for you.
How do I join a post-surgical pain clinical trial?
To join a post-surgical pain clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are post-surgical pain clinical trials free?
Yes, participation in post-surgical pain clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of post-surgical pain treatments are being studied?
Current post-surgical pain clinical trials are testing a range of approaches across NA (13 studies), PHASE4 (7 studies), PHASE2 (6 studies), PHASE1 (3 studies), PHASE3 (2 studies). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 27 research organizations.
Is it safe to participate in post-surgical pain clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 16, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 16, 2026 · Data from ClinicalTrials.gov