Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Xerostomia Clinical Trials
Xerostomia clinical trials are recruiting across 8 cities. Here are the cities with the most active studies:
Xerostomia Trial Phases
5 research organizations are sponsoring xerostomia trials.
About Xerostomia
Xerostomia (dry mouth) is a condition where the salivary glands do not produce enough saliva to keep the mouth moist. It can result from medications, radiation therapy, or autoimmune conditions. Treatment includes saliva substitutes, medications to stimulate saliva production, and dental care.
Clinical trials are advancing new treatments for xerostomia. Currently, 5 studies are recruiting a combined 291 participants across the United States. Research is being conducted by 5 organizations including UNC Lineberger Comprehensive Cancer Center, University of Rochester, RiboX Therapeutics Ltd. and 2 others.
2026 Xerostomia Research Landscape
As of September 2026, the xerostomia clinical trial landscape includes 5 actively recruiting studies across 8 cities in the United States. These studies are collectively seeking 291 participants, with an average enrollment target of 58 per study.
The research spans multiple phases of development: 3 studies are in PHASE1, 2 studies are in PHASE2, 1 study is in NA. Early-phase studies suggest new therapeutic approaches are being explored for xerostomia.
Research is being led by 5 different organizations, including UNC Lineberger Comprehensive Cancer Center, University of Rochester, RiboX Therapeutics Ltd., Stanford University, University of Wisconsin, Madison.
Geographically, xerostomia trials are most concentrated in Chapel Hill, North Carolina (1 trial); Rochester, New York (1 trial); Iowa City, Iowa (1 trial); Baltimore, Maryland (1 trial); New York, New York (1 trial) and 3 other cities.
Featured Xerostomia Studies
Highlighted recruiting studies for xerostomia, selected by enrollment size and research scope.
Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported Xerostomia
Radiation-induced xerostomia (dry mouth) is one of the most common and severe side effects for patients receiving radiation therapy for head and neck cancer. New approaches are needed to reduce this side effect and improve patients' quality of life after treatment. This is a Phase II, single-center, double-masked, parallel-arm, randomized controlled trial. It compares MRI-guided parotid ductal sp...
Study of Non-invasive Acupuncture-like Transcutaneous Electrical Nerve Stimulation (Altens) to Help Alleviate Xerostomia After Radiation Therapy for Cancers of the Head and Neck
The purpose of this study would like to learn if acupuncture-like electrical therapy can be used in patients with head and neck cancer who have had radiation treatment to treat dry mouth.
Study of Circular RNA Treatment in Patients With Radiation Induced Xerostomia-1
This is a first-in-human clinical study to evaluate the safety, tolerability and efficacy of RXRG001 administered in the ducts of the parotid glands in adult patients with radiation-induced xerostomia (dry mouth) and hyposalivation (reduced saliva production). In Part 1 of the study (open-label, single-arm), patients will receive unilateral administrations of RXRG001 in 3 single ascending dose co...
Frequently Asked Questions About Xerostomia Clinical Trials
Are there xerostomia clinical trials near me?
Yes, there are 5 xerostomia clinical trials currently recruiting across 8+ cities in the United States, including Chapel Hill, North Carolina; Rochester, New York; Iowa City, Iowa. Browse the studies above to find one at a location convenient for you.
How do I join a xerostomia clinical trial?
To join a xerostomia clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are xerostomia clinical trials free?
Yes, participation in xerostomia clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of xerostomia treatments are being studied?
Current xerostomia clinical trials are testing a range of approaches across PHASE1 (3 studies), PHASE2 (2 studies), NA (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 5 research organizations.
Is it safe to participate in xerostomia clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated September 1, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated September 1, 2026 · Data from ClinicalTrials.gov