A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia
This study will assess the efficacy and safety of bilateral intra-parotid administration of AAV2-hAQP1 in adults with Grade 2 or Grade 3 radiation-induced late xerostomia....
Study of Circular RNA Treatment in Patients With Radiation Induced Xerostomia-1
This is a first-in-human clinical study to evaluate the safety, tolerability and efficacy of RXRG001 administered in the ducts of the parotid glands in adult patients with radiation-induced xerostomia...
Top Cities for Xerostomia Clinical Trials
Xerostomia clinical trials are recruiting across 11 cities. Here are the cities with the most active studies:
About Xerostomia
Xerostomia (dry mouth) is a condition where the salivary glands do not produce enough saliva to keep the mouth moist. It can result from medications, radiation therapy, or autoimmune conditions. Treatment includes saliva substitutes, medications to stimulate saliva production, and dental care.
Clinical trials are advancing new treatments for xerostomia. Currently, 2 studies are recruiting a combined 318 participants across the United States. Research is being conducted by 2 organizations including MeiraGTx, LLC, RiboX Therapeutics Ltd..
2026 Xerostomia Research Landscape
As of March 2026, the xerostomia clinical trial landscape includes 2 actively recruiting studies across 11 cities in the United States. These studies are collectively seeking 318 participants, with an average enrollment target of 159 per study.
Research is being led by 2 different organizations, including MeiraGTx, LLC, RiboX Therapeutics Ltd..
Geographically, xerostomia trials are most concentrated in Iowa City, Iowa (2 trials); Baltimore, Maryland (2 trials); Gilbert, Arizona (1 trial); Duarte, California (1 trial); Miami, Florida (1 trial) and 6 other cities.
Featured Xerostomia Studies
Highlighted recruiting studies for xerostomia, selected by enrollment size and research scope.
A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia
This study will assess the efficacy and safety of bilateral intra-parotid administration of AAV2-hAQP1 in adults with Grade 2 or Grade 3 radiation-induced late xerostomia.
Study of Circular RNA Treatment in Patients With Radiation Induced Xerostomia-1
This is a first-in-human clinical study to evaluate the safety, tolerability and efficacy of RXRG001 administered in the ducts of the parotid glands in adult patients with radiation-induced xerostomia (dry mouth) and hyposalivation (reduced saliva production). In Part 1 of the study (open-label, single-arm), patients will receive unilateral administrations of RXRG001 in 3 single ascending dose co...
Frequently Asked Questions About Xerostomia Clinical Trials
Are there xerostomia clinical trials near me?
Yes, there are 2 xerostomia clinical trials currently recruiting across 11+ cities in the United States, including Iowa City, Iowa; Baltimore, Maryland; Gilbert, Arizona. Browse the studies above to find one at a location convenient for you.
How do I join a xerostomia clinical trial?
To join a xerostomia clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are xerostomia clinical trials free?
Yes, participation in xerostomia clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of xerostomia treatments are being studied?
Current xerostomia clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 2 research organizations.
Is it safe to participate in xerostomia clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 1, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 1, 2026 · Data from ClinicalTrials.gov