Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Familial Hypercholesterolemia Clinical Trials
Familial Hypercholesterolemia clinical trials are recruiting across 35 cities. Here are the cities with the most active studies:
Familial Hypercholesterolemia Trial Phases
11 research organizations are sponsoring familial hypercholesterolemia trials.
About Familial Hypercholesterolemia
Familial hypercholesterolemia is a genetic condition causing very high LDL cholesterol levels from birth, dramatically increasing the risk of early heart disease. It affects about 1 in 250 people. Treatment includes high-intensity statins, PCSK9 inhibitors, and lifestyle modifications.
Clinical trials are advancing new treatments for familial hypercholesterolemia. Currently, 13 studies are recruiting a combined 2,498 participants across the United States. Research is being conducted by 11 organizations including University of Pennsylvania, Brigham and Women's Hospital, Atlantic Health System and 8 others.
2026 Familial Hypercholesterolemia Research Landscape
As of July 2026, the familial hypercholesterolemia clinical trial landscape includes 13 actively recruiting studies across 35 cities in the United States. These studies are collectively seeking 2,498 participants, with an average enrollment target of 192 per study.
The research spans multiple phases of development: 5 studies are in PHASE3, 3 studies are in NA, 3 studies are in PHASE2, 1 study is in PHASE1. The presence of Phase 3 trials indicates that some familial hypercholesterolemia treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 11 different organizations, including University of Pennsylvania, Brigham and Women's Hospital, Atlantic Health System, Novartis Pharmaceuticals, Merck Sharp & Dohme LLC, and 6 others. The large number of sponsors reflects significant research interest and investment in familial hypercholesterolemia treatment advancement.
Geographically, familial hypercholesterolemia trials are most concentrated in Boca Raton, Florida (4 trials); New York, New York (4 trials); Cincinnati, Ohio (3 trials); Washington D.C., District of Columbia (3 trials); Pittsburgh, Pennsylvania (2 trials) and 7 other cities.
Featured Familial Hypercholesterolemia Studies
Highlighted recruiting studies for familial hypercholesterolemia, selected by enrollment size and research scope.
HoFH, the International Clinical Collaborators Registry
Homozygous familial hypercholesterolemia (HoFH), a rare inherited disorder caused by bi-allelic mutations in the LDL Receptor pathway, is characterized by extremely elevated levels of low-density lipoprotein cholesterol (LDL-C) from birth and premature atherosclerotic cardiovascular disease (ASCVD). Our current knowledge about HoFH is disjointed and largely stems from relatively small case series ...
Computerized Decision Support for Identification and Management of Familial Hypercholesterolemia
The goal of this clinical trial is to learn if a computer alert can aid clinicians in identifying patients with a genetic type of high cholesterol, called Familial Hypercholesterolemia. The main question it aims to answer is whether the computer alert increases recognition of this high cholesterol disorder.
Atlantic Lipid Lowering Treatment Optimization Program
Hypercholesterolemia is recognized as the major driver for cardiovascular morbidity and mortality. To help address this in our community, Atlantic Medical Group (AMG) formed a lipid workgroup chaired by Robert D. Fishberg, MD, and Jeffrey N. Feldman, MD. The overarching goal of the lipid workgroup is to enhance the treatment of lipid disorders in those patients with abnormal lipid levels by improv...
Frequently Asked Questions About Familial Hypercholesterolemia Clinical Trials
Are there familial hypercholesterolemia clinical trials near me?
Yes, there are 13 familial hypercholesterolemia clinical trials currently recruiting across 35+ cities in the United States, including Boca Raton, Florida; New York, New York; Cincinnati, Ohio. Browse the studies above to find one at a location convenient for you.
How do I join a familial hypercholesterolemia clinical trial?
To join a familial hypercholesterolemia clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are familial hypercholesterolemia clinical trials free?
Yes, participation in familial hypercholesterolemia clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of familial hypercholesterolemia treatments are being studied?
Current familial hypercholesterolemia clinical trials are testing a range of approaches across PHASE3 (5 studies), NA (3 studies), PHASE2 (3 studies), PHASE1 (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 11 research organizations.
Is it safe to participate in familial hypercholesterolemia clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 16, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 16, 2026 · Data from ClinicalTrials.gov