MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma
This is a phase III, randomized, open-label, multicenter, global study to determine the efficacy and safety of Volrustomig (MEDI5752) + Carboplatin + Pemetrexed vs the investigator's choice of platinu...
Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma
This phase II trial compares the usual treatment alone (carboplatin, pemetrexed, and bevacizumab) to using immunotherapy (atezolizumab) plus the usual treatment in treating patients with peritoneal me...
A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma
The purpose of this study is to find out whether intraperitoneal or intravenous chemotherapy given after cytoreductive surgery and HIPEC are effective treatments for people with malignant peritoneal m...
Neoadjuvant Durvalumab and Tremelimumab With and Without Chemotherapy for Mesothelioma
Objectives: The investigators will test whether combination of chemoimmunotherapy or dual agent immunotherapy alone improves efficacy for patients with MPM. Primary Objectives: The primary objective...
A Study of Sacituzumab Govitecan in People With Mesothelioma
Participants will receive sacituzumab govitecan until their disease gets worse (progresses), they have severe side effects and cannot continue study treatment, or the participants or the study doctor ...
Testing the Addition of Immunotherapy Before Surgery for Patients With Sarcomatoid Mesothelioma
This phase II trial evaluates the safety and effectiveness of giving immunotherapy (nivolumab and ipilimumab) before surgery for controlling disease in patients with stage I-IIIa sarcomatoid mesotheli...
Top Cities for Mesothelioma Clinical Trials
Mesothelioma clinical trials are recruiting across 32 cities. Here are the cities with the most active studies:
About Mesothelioma
Mesothelioma is a rare cancer that develops in the thin tissue lining the lungs, abdomen, or heart, primarily caused by asbestos exposure. Most cases are pleural mesothelioma affecting the lung lining. Treatment includes surgery, chemotherapy, radiation, and immunotherapy.
Clinical trials are advancing new treatments for mesothelioma. Currently, 6 studies are recruiting a combined 1,066 participants across the United States. Research is being conducted by 5 organizations including AstraZeneca, National Cancer Institute (NCI), Memorial Sloan Kettering Cancer Center and 2 others.
2026 Mesothelioma Research Landscape
As of March 2026, the mesothelioma clinical trial landscape includes 6 actively recruiting studies across 32 cities in the United States. These studies are collectively seeking 1,066 participants, with an average enrollment target of 178 per study.
Research is being led by 5 different organizations, including AstraZeneca, National Cancer Institute (NCI), Memorial Sloan Kettering Cancer Center, Baylor College of Medicine, Alliance for Clinical Trials in Oncology.
Geographically, mesothelioma trials are most concentrated in Anchorage, Alaska (7 trials); Phoenix, Arizona (3 trials); Chicago, Illinois (3 trials); St Louis, Missouri (2 trials); Urbana, Illinois (2 trials) and 7 other cities.
Featured Mesothelioma Studies
Highlighted recruiting studies for mesothelioma, selected by enrollment size and research scope.
MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma
This is a phase III, randomized, open-label, multicenter, global study to determine the efficacy and safety of Volrustomig (MEDI5752) + Carboplatin + Pemetrexed vs the investigator's choice of platinum + Pemetrexed or Nivolumab + Ipilimumab in participants with unresectable pleural mesothelioma.
Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma
This phase II trial compares the usual treatment alone (carboplatin, pemetrexed, and bevacizumab) to using immunotherapy (atezolizumab) plus the usual treatment in treating patients with peritoneal mesothelioma. The usual treatment consists of surgery or chemotherapy. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug c...
A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma
The purpose of this study is to find out whether intraperitoneal or intravenous chemotherapy given after cytoreductive surgery and HIPEC are effective treatments for people with malignant peritoneal mesothelioma. Outcomes will be compared by observing intraperitoneal versus intravenous treatments to analyze if one is better than the other.
Frequently Asked Questions About Mesothelioma Clinical Trials
Are there mesothelioma clinical trials near me?
Yes, there are 6 mesothelioma clinical trials currently recruiting across 32+ cities in the United States, including Anchorage, Alaska; Phoenix, Arizona; Chicago, Illinois. Browse the studies above to find one at a location convenient for you.
How do I join a mesothelioma clinical trial?
To join a mesothelioma clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are mesothelioma clinical trials free?
Yes, participation in mesothelioma clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of mesothelioma treatments are being studied?
Current mesothelioma clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 5 research organizations.
Is it safe to participate in mesothelioma clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 1, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 1, 2026 · Data from ClinicalTrials.gov