16 Brain Cancer Clinical Trials in Baltimore, MD (2026)

Q: How do I join a clinical trial in Baltimore?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Baltimore research site will contact you.

Recruiting Brain Cancer Studies in Baltimore

NCT05902169Recruiting

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

The brain is protected from any toxic or inflammatory molecule by the blood-brain barrier (BBB). This physical barrier is located at the level of the blood vessel walls. Because of these barrier prope...

Baltimore, MDPHASE3560 participantsCarThera

View Study Details

NCT05009992Recruiting

Combination Therapy for the Treatment of Diffuse Midline Gliomas

This phase II trial determines if the combination of ONC201 with different drugs, panobinostat or paxalisib, is effective for treating participants with diffuse midline gliomas (DMGs). Despite years o...

Baltimore, MDPHASE2360 participantsUniversity of California, San Francisco

View Study Details

NCT05658731Recruiting

Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients

The goal of this trial is to determine whether it is possible to minimize radiation dose to parts of the brain that are important for thinking and learning in children who require radiation to treat t...

Baltimore, MDNA338 participantsSidney Kimmel Comprehensive Cancer Center at Johns Hopkins

View Study Details

NCT05124912Recruiting

REMASTer: REcurrent Brain Metastases After SRS Trial

Randomized, post-market multi-center study investigating the efficacy of two sets of treatment algorithms in brain metastases (BM) patients at the time of first intervention for radiographic progressi...

Baltimore, MDNA261 participantsMonteris Medical

View Study Details

NCT07326566Recruiting

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

The purpose of this study is to see if combining silevertinib with temozolomide after surgery and radiotherapy helps treat newly diagnosed glioblastoma (GBM) better than using temozolomide alone in th...

Baltimore, MDPHASE2162 participantsBlack Diamond Therapeutics, Inc.

View Study Details

NCT04775485Recruiting

A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

This is a Phase 2, multi center, open-label study to evaluate the safety and efficacy of Type II RAF (tovorafenib) in pediatric participants with low-grade glioma or advanced solid tumors. Qualifying ...

Baltimore, MDPHASE2141 participantsDay One Biopharmaceuticals, Inc.

View Study Details

NCT05083754Recruiting

Carmustine Wafer in Combination With Retifanlimab and Radiation With/Without Temozolomide in Subjects With Glioblastoma

The purpose of the study is to evaluate the safety and survival of carmustine wafers and radiation and retifanlimab with or without temozolomide (TMZ) in newly-diagnosed adult subjects with glioblasto...

Baltimore, MDPHASE150 participantsSidney Kimmel Comprehensive Cancer Center at Johns Hopkins

View Study Details

NCT04485559Recruiting

Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

This phase I trial studies the side effects and best dose of trametinib and everolimus in treating pediatric and young adult patients with gliomas that have come back (recurrent). Trametinib acts by t...

Baltimore, MDPHASE150 participantsUniversity of California, San Francisco

View Study Details

NCT05303467Recruiting

A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM

The FRONTIER Study is a prospective, interventional, single-arm, multi-center, study to assess the safety and technical feasibility of TheraSphere GBM in patients with recurrent GBM....

Baltimore, MDPHASE136 participantsBoston Scientific Corporation

View Study Details

NCT07375992Recruiting

Music Therapy in Newly Diagnosed Glioblastoma After Chemoradiation Therapy (MELODY-GBM)

The Brain Cancer Program, in partnership with the Center for Music and Medicine at Johns Hopkins, will study whether music therapy is feasible in newly diagnosed GBM patients undergoing standard care....

Baltimore, MDNA35 participantsSidney Kimmel Comprehensive Cancer Center at Johns Hopkins

View Study Details

NCT04181684Recruiting

LITT Followed by Hypofractionated RT for Recurrent Gliomas

The purpose of this study is to evaluate the treatment regimen of using Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat patients with recurrent gliomas....

Baltimore, MDNA32 participantsUniversity of Maryland, Baltimore

View Study Details

NCT04699773Recruiting

LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)

The purpose of this study is to evaluate the treatment regimen of using Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat patients with newly diagnosed gliomas...

Baltimore, MDNA32 participantsUniversity of Maryland, Baltimore

View Study Details

NCT05768919Recruiting

Study of Liposomal Curcumin in Combination With RT and TMZ in Patients With Newly Diagnosed High-Grade Gliomas

The objective of this study is to assess the tolerability, safety, and efficacy of Liposomal Curcumin (LC) in combination with radiotherapy (RT) and Temozolomide (TMZ) in patients with newly diagnosed...

Baltimore, MDPHASE130 participantsSignPath Pharma, Inc.

View Study Details

NCT05317858Recruiting

Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets

The purpose of this study is to evaluate the safety and efficacy of targeted blood brain barrier opening with Exablate Model 4000 Type 2.0/2.1 for the treatment of NSCLC brain metastases in patients w...

Baltimore, MDPHASE330 participantsInSightec

View Study Details

NCT07512154Recruiting

Precision Radiotherapy Enabled by Molecular MRI

This is a research study to determine if a novel molecular magnetic resonance imaging (MRI) technique, called amide proton transfer (APT) imaging, is useful in identifying the most aggressive areas of...

Baltimore, MDNA20 participantsSidney Kimmel Comprehensive Cancer Center at Johns Hopkins

View Study Details

NCT04772456Recruiting

Hyperpolarized 13C-pyruvate Metabolic MRI With Infiltrating Gliomas

The purpose of this study is to examine the safety and feasibility of performing hyperpolarized metabolic MRI in the diagnosis of brain tumor. This study will also assess the accuracy of hyperpolarize...

Baltimore, MDPHASE15 participantsUniversity of Maryland, Baltimore

View Study Details

About Brain Cancer Clinical Trials in Baltimore

Brain cancer includes tumors that originate in the brain (primary) or spread from other areas (metastatic). Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Treatment typically combines surgery, radiation, and chemotherapy, with immunotherapy trials underway.

There are currently 16 brain cancer clinical trials recruiting participants in Baltimore, MD. These studies are seeking a combined 2,142 participants. Research is being sponsored by CarThera, University of California, San Francisco, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and 7 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Brain Cancer Clinical Trials in Baltimore — FAQ

Are there brain cancer clinical trials in Baltimore?

Yes, there are 16 brain cancer clinical trials currently recruiting in Baltimore, MD. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Baltimore?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Baltimore research site will contact you about next steps.

Are clinical trials in Baltimore free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Baltimore studies also compensate for your time and travel.

What brain cancer treatments are being tested?

The 16 active trials in Baltimore are testing new therapies including novel drugs, biologics, and treatment approaches for brain cancer.

Data updated July 20, 2026 from ClinicalTrials.gov