10 Head and Neck Cancer Clinical Trials in Birmingham, AL (2026)

Q: How do I join a clinical trial in Birmingham?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you.

Recruiting Head and Neck Cancer Studies in Birmingham

NCT06129864Recruiting

A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

The main purpose of this study is to assess the efficacy and safety of volrustomig compared to observation in participants with unresected locally advanced head and neck squamous cell carcinoma (LA-HN...

Birmingham, ALPHASE31,145 participantsAstraZeneca

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NCT06788990Recruiting

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

Ficerafusp alfa is directed against two targets, Epidermal Growth Factor Receptor (EGFR) and Transforming Growth Factor beta (TGF-β). This study intends to evaluate the safety and efficacy of ficeraf...

Birmingham, ALPHASE2650 participantsBicara Therapeutics

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NCT01810913Recruiting

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage I...

Birmingham, ALPHASE2613 participantsNational Cancer Institute (NCI)

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NCT04892173Recruiting

JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC

This is a global, open-label, randomized, 2-arm, Investigator's choice Phase 3 (Pivotal Stage) study to investigate the efficacy and safety of JNJ-90301900 (NBTXR3) / radiation therapy (RT)±cetuximab ...

Birmingham, ALPHASE3500 participantsJohnson & Johnson Enterprise Innovation Inc.

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NCT02734537Recruiting

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

This phase II trial studies how well radiation therapy with or without cisplatin works in treating patients with stage III-IVA squamous cell carcinoma of the head and neck who have undergone surgery. ...

Birmingham, ALPHASE2189 participantsECOG-ACRIN Cancer Research Group

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NCT04671667Recruiting

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

This phase II trial studies the effect of pembrolizumab alone compared to the usual approach (chemotherapy \[cisplatin and carboplatin\] plus radiation therapy) after surgery in treating patients with...

Birmingham, ALPHASE2188 participantsNational Cancer Institute (NCI)

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NCT04632654Recruiting

A Motion Exergaming Approach for Symptom Management: HNC

This overall objective of the RCT is to test an intervention to overcome the PA barriers for head and neck cancer (HNC) patients during the first 6 months after their treatment. PAfitME stands for a p...

Birmingham, ALNA150 participantsUniversity of Alabama at Birmingham

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NCT05799144Recruiting

pBI-11 & TA-HPV (With Pembrolizumab as Treatment for Patients w/Advanced, PD-L1 CPS≥1, hrHPV+ Oropharyngeal Cancer

This phase II trial tests how well pB1-11 and human papillomavirus tumor antigen (TA-HPV) vaccines in combination with pembrolizumab work in treating patients with oropharyngeal cancer that has come b...

Birmingham, ALPHASE254 participantsMichael K. Gibson

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NCT06064097Recruiting

A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

This phase II trial tests effects of nivolumab in combination with chemotherapy drugs prior to radiation therapy patients with nasopharyngeal carcinoma (NPC). Immunotherapy with monoclonal antibodies,...

Birmingham, ALPHASE250 participantsNational Cancer Institute (NCI)

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NCT04511078Recruiting

Phase II Panitumumab-IRDye800 in Head & Neck Cancer

The purpose of this study is to determine if panitumumab-IRDye800 is effective in identifying cancer, compared to surrounding normal tissue, and the further characterize the safety profile of this dru...

Birmingham, ALPHASE225 participantsUniversity of Alabama at Birmingham

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About Head and Neck Cancer Clinical Trials in Birmingham

Head and neck cancers develop in the mouth, throat, larynx, sinuses, or salivary glands. HPV-related oropharyngeal cancers have been increasing in prevalence. Treatment includes surgery, radiation, chemotherapy, and immunotherapy.

There are currently 10 head and neck cancer clinical trials recruiting participants in Birmingham, AL. These studies are seeking a combined 3,564 participants. Research is being sponsored by AstraZeneca, Bicara Therapeutics, National Cancer Institute (NCI) and 4 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Head and Neck Cancer Clinical Trials in Birmingham — FAQ

Are there head and neck cancer clinical trials in Birmingham?

Yes, there are 10 head and neck cancer clinical trials currently recruiting in Birmingham, AL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Birmingham?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you about next steps.

Are clinical trials in Birmingham free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Birmingham studies also compensate for your time and travel.

What head and neck cancer treatments are being tested?

The 10 active trials in Birmingham are testing new therapies including novel drugs, biologics, and treatment approaches for head and neck cancer.

Data updated July 19, 2026 from ClinicalTrials.gov