11 ALS Clinical Trials in Boston, NY (2026)

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Recruiting ALS Studies in Boston

NCT05137665Recruiting

Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

The goal of the study is to generate a biorepository of longitudinal biofluids-blood (plasma and serum), cerebral spinal fluid (CSF) and urine linked to genetics and longitudinal clinical information ...

Boston, NY1,000 participantsTarget ALS Foundation, Inc.

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NCT05104710Recruiting

Intermuscular Coherence as a Biomarker for ALS

The specific aims of this study are to: 1. Determine if a painless and quick measurement of muscle activity using surface electrodes can help with the diagnosis of ALS. Specifically, we ask if a meas...

Boston, NY650 participantsUniversity of Chicago

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NCT07322003Recruiting

Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS

The goal of this clinical trial is to learn if the drug pridopidine works to treat amyotrophic lateral sclerosis in adults. It will also help to learn about the safety of pridopidine. The main questio...

Boston, NY500 participantsPrilenia

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NCT07259980Recruiting

A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Participants With Superoxide Dismutase 1 (SOD-1) Amyotrophic Lateral Sclerosis (ALS)

In this study, researchers will learn more about the safety of tofersen, also known as Qalsody®. This is a drug available for doctors to prescribe for participant with a certain type of amyotrophic la...

Boston, NY125 participantsBiogen

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NCT06491732Recruiting

EIM Via the Myolex mScan as an ALS Biomarker

Amyotrophic lateral sclerosis (ALS) has been traditionally considered incurable and untreatable. But starting in the 1990s with the introduction of Riluzole, therapies are being discovered and ultimat...

Boston, NY80 participantsBeth Israel Deaconess Medical Center

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NCT06665165Recruiting

AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis

This study is a placebo-controlled Phase I study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the antisense oligonucleotide (ASO) AMX0114 in adult participants with ...

Boston, NY48 participantsAmylyx Pharmaceuticals Inc.

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NCT04220190Recruiting

RAPA-501 Therapy for ALS

RAPA-501-ALS is a phase 2/3 expansion cohort study of RAPA-501 autologous hybrid TREG/Th2 cells in patients living with amyotrophic lateral sclerosis (pwALS)....

Boston, NY41 participantsRapa Therapeutics LLC

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NCT07294144Recruiting

Tofersen in Non-SOD1 ALS

The goal of this clinical trial is to evaluate whether tofersen is safe and effective in adults with non-SOD1 ALS. Tofersen is currently approved by the U.S. Food and Drug Administration to treat SOD1...

Boston, NY30 participantsWashington University School of Medicine

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NCT06649955Recruiting

Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study

Following completion of the ALS Early Feasibility Study of the MyoRegulator® device for treatment of ALS (NCT06165172), the CALM study will further assess the feasibility of the MyoRegulator® device t...

Boston, NY15 participantsPathMaker Neurosystems Inc.

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NCT07287397Recruiting

Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS

PIONEER-ALS is a Phase 1/2, multicenter, open-label, ascending dose, uncontrolled, first-in-human study that will evaluate the safety, tolerability and effects on clinical and biomarker endpoints of i...

Boston, NY12 participantsVector Y Therapeutics

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NCT07357428Recruiting

Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)

The Connect-One Study is an early feasibility study to obtain preliminary device safety information for the Connexus Brain-Computer Interface (BCI). The Connexus BCI is intended to be used as: (1) an ...

Boston, NY2 participantsParadromics

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About ALS Clinical Trials in Boston

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons controlling voluntary muscle movement. Also known as Lou Gehrig's disease, it leads to increasing paralysis. Research is actively pursuing disease-modifying treatments and gene therapies.

There are currently 11 als clinical trials recruiting participants in Boston, NY. These studies are seeking a combined 2,503 participants. Research is being sponsored by Target ALS Foundation, Inc., University of Chicago, Prilenia and 8 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

ALS Clinical Trials in Boston — FAQ

Are there als clinical trials in Boston?

Yes, there are 11 als clinical trials currently recruiting in Boston, NY. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What als treatments are being tested?

The 11 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for als.

Data updated July 13, 2026 from ClinicalTrials.gov