36 Multiple Sclerosis Clinical Trials in Boston, NY (2026)

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Recruiting Multiple Sclerosis Studies in Boston

NCT01353547Recruiting

Genes and Environment in Multiple Sclerosis

The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease cause...

Boston, NY5,000 participantsColumbia University

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NCT00756665Recruiting

Prostate Active Surveillance Study

The Prostate Active Surveillance Study (PASS) is a research study for men who have chosen active surveillance as a management plan for their prostate cancer. Active surveillance is defined as close mo...

Boston, NY3,000 participantsUniversity of Washington

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NCT00843375Recruiting

Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas

Colon cancer is the second most common cancer in men and women. It is a disease that can be prevented if it is found early. Colonoscopy is still the best screening tool for colon cancer and the polyps...

Boston, NY1,200 participantsUniversity of Michigan Rogel Cancer Center

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NCT07299019Recruiting

A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis

Orelabrutinib is a CNS-penetrable BTK inhibitor. This is a phase 3, randomized, double-blind, parallel-group, multicenter study to evaluate the efficacy and safety of orelabrutinib compared with place...

Boston, NY990 participantsZenas BioPharma (USA), LLC

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NCT06131840Recruiting

A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

This clinical trial is studying advanced solid tumors. Solid tumors are cancers that start in a part of your body like your lungs or liver instead of your blood. Once tumors have grown bigger in one p...

Boston, NY914 participantsSeagen, a wholly owned subsidiary of Pfizer

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NCT06551142Recruiting

A Study of GSK5764227 in Participants With Advanced Solid Tumors (EMBOLD)

The goal of this study is to assess the safety, tolerability, clinical activity and pharmacokinetics of Risvutatug rezetecan (Ris-Rez), also known as GSK5764227. The study will also see how the levels...

Boston, NY845 participantsGlaxoSmithKline

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NCT04603196Recruiting

Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis

This study will evaluate the influence of sleep apnea on clinical and radiological features of MS. Sleep apnea is associated with hypoxemia during sleep, which is likely detrimental to MS. Clinical da...

Boston, NY800 participantsBeth Israel Deaconess Medical Center

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NCT07114601Recruiting

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

The main purpose of this study is to evaluate safety, tolerability, and efficacy of LY4257496 alone and as part of relevant standard of care (SOC) combination therapy in participants with Gastrin-rele...

Boston, NY421 participantsEli Lilly and Company

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NCT07525843Recruiting

A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: WE BEAT CHD Study

The goal of this pragmatic clinical trial is to learn if the WE BEAT program, a 5-week group-based online wellbeing and skill-building program, can help teens with congenital heart disease (CHD) impro...

Boston, NY390 participantsCarelon Research

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NCT07011914Recruiting

Care in Multiple Sclerosis (MS)

This study is structured around three main aims. In Aim 1, investigators will conduct community-based participatory research (CBPR) to develop culturally tailored methods to assess childhood adversit...

Boston, NY300 participantsNYU Langone Health

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NCT06034002Recruiting

A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms

This study is being conducted to evaluate the safety, tolerability, dose-limiting toxicity (DLT) and determine the maximum tolerated dose (MTD) and/or recommended dose(s) for expansion (RDE) of INCA03...

Boston, NY290 participantsIncyte Corporation

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NCT04794322Recruiting

Developing a Test of Uterine Lavage for the Detection of Ovarian Cancer

The study aims to develop a test for early detection of ovarian cancer using DNA from a growth involving the ovary found in a washing of the uterus (womb), and proteins found in the blood. The samples...

Boston, NY250 participantsMassachusetts General Hospital

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NCT02649985Recruiting

PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases

The specific aims of the study are: Primary: To determine the presence and regional distribution of microglial activation, as assessed by Fluorine-18 (18F) labeled "Peripheral Benzodiazepine Receptor...

Boston, NY250 participantsBrigham and Women's Hospital

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NCT07213791Recruiting

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

This is a study of LY4337713 in participants with certain types of cancer that is advanced or has spread. Participants must have cancer with high levels of a protein called fibroblast activation prote...

Boston, NY241 participantsEli Lilly and Company

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NCT05773144Recruiting

Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer

To goal of this clinical trial is to quantify the dose-response effects of aerobic exercise training compared to attention control on chemotherapy relative dose intensity in colon cancer survivors....

Boston, NY219 participantsAdventHealth Translational Research Institute

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NCT07441694Recruiting

Study of INCA036978 in Participants With Myeloproliferative Neoplasms

This study will be conducted to determine the safety, tolerability, dose-limiting toxicity (DLT)s, and maximum tolerated dose (MTD) and/or recommended dose for expansion (RDE)s of INCA036978 administe...

Boston, NY218 participantsIncyte Corporation

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NCT05004051Recruiting

ViTAA Registry Pre- and Post-Operative Monitoring for Endovascular Aortic Aneurysm Repair and Serial Monitoring for AAA

This is a Prospective Registry study to collect imaging and clinical data both on patients with aortic aneurysm disease undergoing serial monitoring and on patients pre and post-endovascular repair, u...

Boston, NY200 participantsViTAA Medical Solutions

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NCT06735248Recruiting

A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years

The primary objective of this trial is to evaluate the safety and reactogenicity of mRNA-1195 in participants with multiple sclerosis....

Boston, NY180 participantsModernaTX, Inc.

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NCT05814146Recruiting

Trial of Variable Dialysate Bicarbonate

QTc prolongation and premature ventricular contractions (PVCs) are common in hemodialysis (HD) patients and are associated with sudden cardiac death. It is known that higher dialysate bicarbonate is ...

Boston, NY141 participantsBrigham and Women's Hospital

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NCT05285891Recruiting

Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis

This study is a prospective, multi-center, randomized, double blinded, placebo-controlled study of OCR treatment-discontinuation in patients with early RMS. All eligible participants will be initiated...

Boston, NY123 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT06220201Recruiting

A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis, Progressive Forms of Multiple Sclerosis or Refractory Myasthenia Gravis (MG) (Breakfree-2)

The purpose of this study is to evaluate the safety, tolerability, efficacy, and drug levels of CC-97540 in participants with Relapsing Forms of Multiple Sclerosis (RMS), Progressive Forms of Multiple...

Boston, NY120 participantsJuno Therapeutics, Inc., a Bristol-Myers Squibb Company

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NCT07008118Recruiting

A Study to Evaluate INCA035784 in Participants With Myeloproliferative Neoplasms

This study is being conducted to evaluate the safety and tolerability of INCA035784 in participants with myeloproliferative neoplasms....

Boston, NY120 participantsIncyte Corporation

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NCT05921201Recruiting

Preventing Depression of Chinese American Adolescents by RRE

The goal of this clinical trial is to test if a culturally sensitive mobile health application (Relax, Reflect, Empower-RRE) is feasible and effective in promoting psychological wellbeing and reducing...

Boston, NY110 participantsNortheastern University

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NCT05897021Recruiting

Expressive Writing on Minority Stressors Among Sexual Minority Veterans

Sexual minority stressors (e.g., sexual minority identity-based discrimination) contribute to greater risk for and severity of depression, anxiety, substance use disorders and suicide among sexual min...

Boston, NY85 participantsVA Office of Research and Development

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NCT06554340Recruiting

Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension

The goal of this study is to determine if 12 weeks of cycling exercise training at home will improve three parameters: 1) blood pressure, 2) cognition, and 3) walking ability among persons with multip...

Boston, NY80 participantsUniversity of Massachusetts, Boston

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NCT04699747Recruiting

Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects

Our overall objective is to obtain an initial assessment of the potential value of using \[18F\]3F4AP for imaging demyelinating diseases such as multiple sclerosis: * Aim 1) Assess the safety of \[18...

Boston, NY60 participantsMassachusetts General Hospital

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NCT06890923Recruiting

Nasal Foralumab in Patients With Non-Active Secondary Progressive Multiple Sclerosis

Only subjects that have completed TILS-021, a Phase 2a Randomized, Double-Blind, Placebo-Controlled, Multicenter Dose-Ranging Study of Nasal Foralumab in Non-Active Secondary Progressive Multiple Scle...

Boston, NY55 participantsTiziana Life Sciences LTD

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NCT07087106Recruiting

Glucose Consumption in MS Using [F-18]FDG-PET

Given the need for better diagnostic imaging techniques in multiple sclerosis (MS), the study aims to investigate the utility of \[F-18\]FDG positron emission tomography (PET) in MS. The study will be...

Boston, NY50 participantsBrigham and Women's Hospital

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NCT06136728Recruiting

Dalfampridine Combined With Physical Therapy for Mobility Impairment in Multiple Sclerosis

The goal of this clinical trial is to evaluate if combining a medication that can help improve walking in people with multiple sclerosis (MS) with a physical therapy program is better for improving wa...

Boston, NY48 participantsMGH Institute of Health Professions

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NCT05985161Recruiting

A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors

The purpose of this study is to find out whether selinexor is an effective treatment for people who have a relapsed/refractory Wilms tumor, rhabdoid tumor, MPNST, or another solid tumor that makes a h...

Boston, NY45 participantsMemorial Sloan Kettering Cancer Center

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NCT07258836Recruiting

A Study of [18F]LY4214835 in Healthy Volunteers and Participants With Cancer

The purpose of the study is to check how safe and well-tolerated \[18F\]LY4214835 injection is in healthy participants and participants with cancer. The study drug will be administered intravenously (...

Boston, NY41 participantsEli Lilly and Company

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NCT04634994Recruiting

Assessment of Synaptic Density in MS

The investigators propose to use the novel SV2a-PET ligand, \[F-18\]SDM-8 to assess synaptic density in progressive multiple sclerosis (PMS) (including primary progressive multiple sclerosis (PPMS) an...

Boston, NY30 participantsBrigham and Women's Hospital

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NCT07026877Recruiting

Endovascular Repair With Fenestrated TREO Stent-Graft System in AAA

The goal of this clinical trial is to learn if the Fenestrated TREO Stent-Graft System works to treat abdominal aneurysms in adults. An abdominal aneurysm is a bulge in the main blood vessel (the aort...

Boston, NY20 participantsBolton Medical

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NCT03207464Recruiting

Molecular Imaging of NET Using [C-11]MRB-PET in MS

This study aims to use \[C-11\]MRB PET (positron emission tomography) imaging to look at brain injury in patients with Multiple Sclerosis (MS) and healthy individuals. The overarching hypothesis is th...

Boston, NY19 participantsBrigham and Women's Hospital

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NCT06143514Recruiting

A Study Evaluating the Presence and Concentration of BRIUMVI™ (Ublituximab) in Breast Milk

The primary objective of the lactation study is to characterize the presence and concentration of BRIUMVI™ in breast milk among breastfeeding participants who receive BRIUMVI™ therapeutically for the ...

Boston, NY16 participantsTG Therapeutics, Inc.

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NCT07128355Recruiting

Botensilimab, Balstilimab, and SBRT in Colorectal Cancer

This is a single-arm pilot feasibility study evaluating the combination of Botensilimab and Balstilimab with Radiation Therapy (RT) in Non-Microsatellite Instability High (MSI-H) or Proficient Mismatc...

Boston, NY15 participantsMassachusetts General Hospital

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About Multiple Sclerosis Clinical Trials in Boston

Multiple sclerosis (MS) is an autoimmune disease where the immune system attacks the protective covering of nerve fibers, causing communication problems between the brain and body. Symptoms vary widely and can include vision problems, fatigue, and mobility issues. Disease-modifying therapies have significantly improved outcomes.

There are currently 36 multiple sclerosis clinical trials recruiting participants in Boston, NY. These studies are seeking a combined 16,886 participants. Research is being sponsored by Columbia University, University of Washington, University of Michigan Rogel Cancer Center and 23 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Multiple Sclerosis Clinical Trials in Boston — FAQ

Are there multiple sclerosis clinical trials in Boston?

Yes, there are 36 multiple sclerosis clinical trials currently recruiting in Boston, NY. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What multiple sclerosis treatments are being tested?

The 36 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for multiple sclerosis.

Data updated July 13, 2026 from ClinicalTrials.gov