85 Ankylosing Spondylitis Clinical Trials in Boston, NY (2026)

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Recruiting Ankylosing Spondylitis Studies in Boston

NCT04604418Recruiting

Outcomes and Health Care Resource Utilization in Pediatric Congenital Heart Disease Patients Undergoing Non-Cardiac Procedures

The incidence of moderate to severe congenital heart disease (CHD) in the United States is estimated to be 6 per 1000 live-born full term infants. Recent advances in pediatric cardiology, surgery and ...

Boston, NY10,000 participantsBoston Children's Hospital

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NCT01193075Recruiting

Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others

This is an observational longitudinal study to determine the natural history and genotype-phenotype correlations of disease causing mutations in Charcot Marie Tooth disease (CMT) type 1B (CMT1B), 2A (...

Boston, NY5,000 participantsMichael Shy

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NCT06888388Recruiting

Long-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast Cancer

Patients with a germline pathogenic variant (GPV) in high-penetrance breast cancer susceptibility genes who are considering risk reducing mastectomy (RRM) often strongly desire to keep their nipple ar...

Boston, NY4,700 participantsSir Mortimer B. Davis - Jewish General Hospital

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NCT06658730Recruiting

Long-term Characterization of GORE® TAG® Conformable Thoracic Stent Graft With ACTIVE CONTROL System Performance

An observational, prospective multi-regional post-market registry collecting mid- and long-term data to assess outcomes through ten years of follow-up for subjects treated with GORE® TAG® Conformable ...

Boston, NY1,500 participantsW.L.Gore & Associates

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NCT06970977Recruiting

CRS Questionnaire Validation Project

The 'CRS validation project' consists of a joint effort of 32 medical centers in Europe, the USA, and South Africa to carry out the validation of 2 novel questionnaires designated to measure self-perc...

Boston, NY1,000 participantsThe European Forum for Research and Education in Allergy and Airway Diseases

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NCT06310031Recruiting

Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

The goal of this study is to evaluate the safety and efficacy of the BrioVAD System by demonstrating non-inferiority to the HeartMate 3 Left Ventricular Assist System when used for the treatment of ad...

Boston, NY780 participantsBrioHealth Solutions, Inc.

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NCT00869817Recruiting

Dominantly Inherited Alzheimer Network (DIAN)

The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation....

Boston, NY700 participantsWashington University School of Medicine

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NCT04712812Recruiting

Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia

The Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia (HSP) is focused on gathering longitudinal clinical data as well as biological samples (skin and/or blood and/or sa...

Boston, NY700 participantsBoston Children's Hospital

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NCT06667414Recruiting

Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers

For participation in this epidemiological study, a single-day visit at the study site is required. Participants will be recruited from Huntington Disease clinics, and they will be asked to answer ques...

Boston, NY600 participantsHoffmann-La Roche

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NCT06104852Recruiting

Triage Survey for Neurology Research Eligibility

TRIAGE-Neuro is a survey study designed to assess potential participants' eligibility to screen for industry-sponsored neurology clinical trials....

Boston, NY600 participantsAdams Clinical

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NCT02610439Recruiting

Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Peripheral Neuropathy Receiving Paclitaxel for Breast Cancer

This research trial studies whole exome sequencing in finding causative variants in germline deoxyribonucleic acid (DNA) samples from patients with peripheral neuropathy receiving chemotherapy for bre...

Boston, NY575 participantsNational Cancer Institute (NCI)

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NCT06976268Recruiting

A Study to Determine if BHV-8000 is Effective, Safe and Tolerable as a Treatment for Adults Living With Early Parkinson's Disease

A study to determine if BHV-8000 is efficacious, safe and tolerable in adults diagnosed with early Parkinson's disease....

Boston, NY550 participantsBiohaven Therapeutics Ltd.

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NCT06089083Recruiting

PROmOting Gynecologic Cancer Patients With Frailty to Achieve Functional Recovery

This study seeks to understand how frailty, a term that describes people who are more vulnerable stressors such as a new medical problem, affects the outcomes and quality of life in adult patients wit...

Boston, NY500 participantsUniversity of California, San Francisco

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NCT07087431Recruiting

Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular Health

The goal of this clinical trial is to evaluate whether disclosure of a polygenic risk score for coronary artery disease (CAD PRS) influences cardiovascular health and risk factor modification over one...

Boston, NY500 participantsMassachusetts General Hospital

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NCT04708171Recruiting

The PROGRAM-study: Awake Mapping Versus Asleep Mapping Versus No Mapping for Glioblastoma Resections

The study is designed as an international, multicenter prospective cohort study. Patients with presumed glioblastoma (GBM) in- or near eloquent areas on diagnostic MRI will be selected by neurosurgeon...

Boston, NY453 participantsErasmus Medical Center

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NCT05581004Recruiting

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors

This is a first-in-human study to evaluate the safety, tolerability, pharmacokinetics (PK), and anti-tumor activity of enzelkitug when administered as a single agent and in combination with atezolizum...

Boston, NY450 participantsGenentech, Inc.

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NCT06212947Recruiting

A Multicenter Multinational Observational Study of Children With Hypochondroplasia

This study will assess growth over time and the clinical course of HCH in children by collecting growth measurements and other variables of interest....

Boston, NY400 participantsBioMarin Pharmaceutical

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NCT05866302Recruiting

Parametric Response Mapping (PRM) for the Detection of Chronic Lung Injury in Hematopoietic Cell Transplant Recipients

The study will have two separate patient cohorts: Cohort 1 will include patients with newly diagnosed chronic graft versus host disease (GVHD), whereas cohort 2 will include patients with newly diagno...

Boston, NY375 participantsUniversity of Michigan Rogel Cancer Center

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NCT07123649Recruiting

Individualizing Approaches to Surveillance Mammography in Older Breast Cancer Survivors - The I-MAMMO Study

This study evaluates the effectiveness of a Shared Decision-Making (SDM) toolkit designed to support older breast cancer survivors aged 80 and above in making informed decisions about continuing surve...

Boston, NY364 participantsDana-Farber Cancer Institute

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NCT02610413Recruiting

Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Hypertension Receiving Bevacizumab for Breast Cancer

This research trial studies whole exome sequencing in finding causative variants in germline deoxyribonucleic acid (DNA) samples from patients with hypertension receiving bevacizumab for breast cancer...

Boston, NY354 participantsNational Cancer Institute (NCI)

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NCT00985049Recruiting

TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)

Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small p...

Boston, NY350 participantsBrigham and Women's Hospital

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NCT06136091Recruiting

Protocol CAUSE-03 / CHEETAH

This is a one-year longitudinal, observational study of 250 urban children and adolescents with asthma and 60 without asthma, ages 6-17 years old. Participants with asthma will require daily controll...

Boston, NY310 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT06026410Recruiting

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

This first-in-human (FIH) dose-escalation and dose-validation/expansion study will assess KO-2806, a farnesyltransferase inhibitor (FTI), as a monotherapy and in combination, in adult patients with ad...

Boston, NY300 participantsKura Oncology, Inc.

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NCT06592820Recruiting

Endoscopic Ultrasound Shear Wave Elastography Study

This study shall be a prospective, multicenter, single arm, consecutive, interventional study conducted in a post-market setting using commercially available devices. Consecutive, eligible patients wi...

Boston, NY300 participantsOlympus Corporation of the Americas

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NCT03741777Recruiting

Comparison of Residual Gastric Volume Between Children Who Drink Different Clear Oral Fluid Volume

According to the American Society of Anesthesiologists (ASA) fasting guideline for patients undergoing elective surgery, the 2-hour fasting period is suggested for clear oral fluid (including water, p...

Boston, NY288 participantsBoston Children's Hospital

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NCT02860364Recruiting

Comparing Hypothermic Temperatures During Hemiarch Surgery

Hypothermic circulatory arrest is an important surgical technique, allowing complex aortic surgeries to be performed safely. Hypothermic circulatory arrest provides protection to cerebral and visceral...

Boston, NY282 participantsOttawa Heart Institute Research Corporation

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NCT05890677Recruiting

The LYMPH Trial - Microsurgical Versus Conservative Treatment of Chronic Breast Cancer Associated Lymphedema

The aim of this study is to test whether lymphatic surgery provides better QoL (assessed with the Lymph-ICF-UL, (Lymphedema Functioning Disability and health questionnaire for upper limb lymphedema)) ...

Boston, NY280 participantsUniversity Hospital, Basel, Switzerland

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NCT06188585Recruiting

Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Bleeding

A prospective, multi-center, noninferiority randomized controlled trial designed to compare the efficacy of UI-EWD (Nexpowder™) hemostatic powder versus conventional endoscopic hemostatic therapy in p...

Boston, NY278 participantsMedtronic - MITG

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NCT04794322Recruiting

Developing a Test of Uterine Lavage for the Detection of Ovarian Cancer

The study aims to develop a test for early detection of ovarian cancer using DNA from a growth involving the ovary found in a washing of the uterus (womb), and proteins found in the blood. The samples...

Boston, NY250 participantsMassachusetts General Hospital

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NCT07213791Recruiting

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

This is a study of LY4337713 in participants with certain types of cancer that is advanced or has spread. Participants must have cancer with high levels of a protein called fibroblast activation prote...

Boston, NY241 participantsEli Lilly and Company

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NCT06993844Recruiting

Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors

Phase 1/2, open-label study of ETX-636 in participants with advanced solid tumors...

Boston, NY233 participantsEnsem Therapeutics

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NCT05998330Recruiting

LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver Disease

The goal of this clinical trial is to evaluate whether early integration of palliative care in the care of hospitalized patients with advanced liver disease (AdvLD) can improve patients' quality of li...

Boston, NY200 participantsMassachusetts General Hospital

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NCT05354622Recruiting

Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)

The purpose of the HSP Sequencing Initiative is to better understand the role of genetics in hereditary spastic paraplegia (HSP) and related disorders. The HSPs are a group of more than 80 inherited n...

Boston, NY200 participantsBoston Children's Hospital

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NCT05776641Recruiting

Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People at Risk for Alzheimer's Disease

Alzheimer's disease (AD) is characterized by significant memory loss, toxic protein deposits (amyloid and tau) in the brain, and changes in the gamma frequency band on EEG. Gamma waves are important f...

Boston, NY200 participantsMassachusetts General Hospital

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NCT06759649Recruiting

A Clinical Trial to Assess COM503 in Participants With Advanced Solid Malignancies

The overall goal of this first-in-human (FIH) clinical trial is to learn about the safety and dosing of COM503 when given alone or in combination with zimberelimab in participants with advanced solid ...

Boston, NY200 participantsCompugen Ltd

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NCT01401998Recruiting

ARPKD Database Study

Hepato-renal fibrocystic diseases (HRFD) is a term developed that encompasses rare diseases such as Autosomal Recessive Polycystic Kidney Disease (ARPKD), and other diseases with common features (Joub...

Boston, NY200 participantsChildren's Hospital of Philadelphia

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NCT07131592Recruiting

Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction Surgery

This study aims to evaluate whether tranexamic acid (TXA), a medication that helps reduce bleeding, can decrease fluid drainage after breast reduction surgery. Participants will be randomly assigned t...

Boston, NY160 participantsMassachusetts General Hospital

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NCT07211035Recruiting

Effect of the Amplifi™ Vein Dilation System on Outflow Vein Dilation and AV Fistula Maturation (AMPLIFI-1)

The AMPLIFI-1 Study is a prospective, multicenter pivotal clinical trial designed to evaluate the safety and effectiveness of the Amplifi™ Vein Dilation System in patients requiring distal arterioveno...

Boston, NY160 participantsAmplifi Vascular, Inc.

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NCT06781983Recruiting

Safety and Tolerability of IPH4502 in Patients With Advanced Solid Tumors

This is a first-in-human, open-label, multicenter, Phase 1 study to evaluate the safety, tolerability and preliminary efficacy of IPH4502 and to determine the recommended Phase 2 dose (RP2D) in advanc...

Boston, NY145 participantsInnate Pharma

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NCT06240728Recruiting

A Study of NPX887 for Participants With Solid Tumors Known to Express B7-H7/HHLA2

NPX887 is a human, antagonistic immunoglobulin G1 (IgG1) monoclonal antibody targeting B7-H7 (HHLA2) that may potentiate an anti-tumor immune response. The goal of this first-in-human study is to lear...

Boston, NY144 participantsNextPoint Therapeutics, Inc.

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NCT06067841Recruiting

A Study to Assess BMS-986460 in Participants With Metastatic Castration-resistant Prostate Cancer

The purpose of this study is to assess the safety, tolerability, and preliminary efficacy of BMS-986460 in men with Metastatic Castration-resistant Prostate Cancer....

Boston, NY140 participantsBristol-Myers Squibb

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NCT06879041Recruiting

A Phase I Study of [225Ac]-AZD2284 in Patients With Metastatic Castration-Resistant Prostate Cancer

The main purpose of the study is to assess the safety and tolerability of AZD2284, AZD2287, and AZD2275....

Boston, NY136 participantsAstraZeneca

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NCT05934565Recruiting

Mindful Steps 2.0: Promoting Physical Activity in Patients With COPD and HF

The goal of this fully-remote randomized controlled trial is to test the efficacy of Mindful Steps in facilitating physical activity compared to usual standard of care among 136 patients with COPD and...

Boston, NY136 participantsBeth Israel Deaconess Medical Center

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NCT07630974Recruiting

A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)

Researchers are looking for new ways to treat children with relapsed or refractory solid tumors: * Relapsed means the cancer came back after treatment * Refractory means the cancer did not respond (g...

Boston, NY134 participantsMerck Sharp & Dohme LLC

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NCT07190196Recruiting

A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults Diagnosed With IgG4-related Disease

This is a Phase 3, parallel group, 2-arm, randomized, double blind, placebo-controlled, 52-week treatment study to assess the efficacy and safety of rilzabrutinib as a treatment for adult patients wit...

Boston, NY124 participantsSanofi

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NCT07421830Recruiting

An Empowering Parent Training Intervention to Increase Physical Activity in Preschool Aged Children With Autism

The goal of this clinical trial is to learn if WE PLAY for Parents can improve caregivers' knowledge, attitudes, confidence, and skills promoting physical activity with their young child with autism. ...

Boston, NY114 participantsNortheastern University

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NCT05995353Recruiting

A Study to Assess Adverse Events, Change in Disease Activity, and How Intravenous and Subcutaneous Risankizumab Moves Through the Body of Pediatric Participants With Moderately to Severely Active Crohn's Disease

Crohn's Disease (CD) is a gastrointestinal disease that can cause chronic diarrhea with or without gross bleeding, abdominal pain, weight loss, and fever. This study will assess the pharmacokinetics, ...

Boston, NY110 participantsAbbVie

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NCT05491668Recruiting

Physiological Assessment of Severe Coronary Stenosis for Informing Planned PCI

Traditionally, the severity of a blockage (stenosis) in a coronary artery has been determined by visual angiographic assessment of the diameter of the artery at the level of a blockage compared to a n...

Boston, NY107 participantsBeth Israel Deaconess Medical Center

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NCT07225621Recruiting

Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

The purpose of this research is to test an investigational device using ultrasound along with an investigational drug to see if it is useful in treating glioblastoma following standard of care therapy...

Boston, NY103 participantsAlpheus Medical, Inc.

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NCT07305818Recruiting

NEXUS Study: A Study to Test Single and Multiple Doses of MER511 Given to Adults With Graves' Disease

The purpose of this study is to evaluate how well MER511 is tolerated and what side effects may occur in adults who have Graves' disease. The study drug will be administered either intravenously (into...

Boston, NY100 participantsMerida Biosciences

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NCT06936566Recruiting

MAGIC Ruxolitinib for aGVHD

This clinical trial will study ruxolitinib-based treatment of acute graft-versus-host-disease (GVHD) that developed following allogeneic hematopoietic cell transplant. Acute GVHD occurs when donor cel...

Boston, NY98 participantsJohn Levine

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NCT06713382Recruiting

Evaluating the Efficacy and Safety of Saline Irrigation as an Add-On Therapy for Retained Pleural Infections [LYTICS +]

The purpose of this protocol is to conduct a pilot prospective non-blind clinical trial to evaluate the efficacy and safety of a novel saline irrigation technique as an adjunct to standard interventio...

Boston, NY96 participantsBeth Israel Deaconess Medical Center

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NCT06401044Recruiting

A Study of AMG 732 in Healthy Participants and Participants With Thyroid Eye Disease

The primary objective of Part A of this study is to investigate the safety and tolerability of AMG 732 after single subcutaneous (SC) doses. The primary objective of Part B of this study is to investi...

Boston, NY88 participantsAmgen

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NCT05996627Recruiting

Belumosudil for the Pre-emptive Treatment of Patients With Chronic Graft Versus Host Disease

This phase II trial compares the effect of belumosudil to a placebo in treating patients with chronic graft versus host disease. Chronic graft versus host disease remains a major complication of stem ...

Boston, NY82 participantsFred Hutchinson Cancer Center

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NCT05332639Recruiting

Personalized Risk Estimation for Crohn's Disease (PRE-Crohn's): Implementation and Feasibility

The aim of this study is to develop and assess the feasibility and effect of a web-based, personalized risk-estimation for Crohn's disease (PRE-Crohn's) tool on behaviors and biomarkers associated wit...

Boston, NY80 participantsMassachusetts General Hospital

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NCT07077395Recruiting

Finding Links Between Hot flASHes and CardioVascular Disease

The goal of this clinical trial is to learn if drug fezolinetant improves blood vessel health in women with moderate to severe hot flashes. The main questions it aims to answer are: Does drug fezolin...

Boston, NY80 participantsMassachusetts General Hospital

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NCT06994676Recruiting

A Study of CBX-250 in Participants With Relapsed or Refractory Myeloid Leukemias

Study CBX-250-001 is a Phase 1, open-label, dose-escalation study of CBX-250 in participants with relapsed/refractory AML, HR-MDS, CMML, and CML. Participants aged ≥ 12 years are planned to be enrolle...

Boston, NY72 participantsCrossbow Therapeutics, Inc.

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NCT06439693Recruiting

The SAPPHO Study: Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancer

The purpose of this study is to test the safety and effectiveness of a sequence of drugs (a Taxane plus Trastuzumab plus Pertuzumab followed by Trastuzumab Deruxtecan, followed by Tucatinib plus Ado-T...

Boston, NY72 participantsDana-Farber Cancer Institute

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NCT05721859Recruiting

M-Vizion™ Macroscopic Radiographic Study

Study of the patient's subsidence after revision hip arthroplasty by assessing gross stem subsidence in the femoral canal....

Boston, NY70 participantsMedacta USA

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NCT07419841Recruiting

A Phase 1 Study of the Safety and Tolerability of CTX-10726

This is a Phase 1, open-label, first-in-human study of CTX-10726 monotherapy in patients with metastatic or locally advanced malignancies. The study will be conducted in 2 Cohorts: Cohort 1 Dose Escal...

Boston, NY70 participantsCompass Therapeutics

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NCT07525375Recruiting

A Phase II Study to Investigate Lung Function With 2 Different Doses of Inhaled Glycopyrronium Taken With BFF Compared to BFF in Participants of 4 to Less Than 12 Years of Age With Asthma

The purpose of this study is to evaluate the effect of 2 different GP metered dose inhaler (MDI) doses relative to placebo MDI as add-on treatment to BFF MDI on lung function in participants 4 to less...

Boston, NY69 participantsAstraZeneca

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NCT05674643Recruiting

Gastric Assessment of Pediatric Patients Undergoing Surgery

The goal of this pilot prospective cohort study is to examine the reproducibility of gastric volume and emptying as measured by gastric ultrasound and its correlation to a gold-standard test for gastr...

Boston, NY60 participantsBoston Children's Hospital

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NCT04833140Recruiting

Estrogen Administration for the Treatment of NASH in Postmenopausal Women

Non-alcoholic fatty liver disease (NAFLD) is a growing epidemic in the United States. Despite this, the treatment options remain limited. Preclinical and preliminary clinical data suggest that estroge...

Boston, NY60 participantsMassachusetts General Hospital

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NCT06942572Recruiting

A Phase 1/2, First-in-Human Dose Escalation/Expansion Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of a Subretinal Injection of SB-007 in Subjects With Stargardt Disease (STGD1)

This Phase 1/2 study will evaluate the safety, tolerability, and preliminary efficacy of subretinal SB-007 administration to determine dose selection in subjects with Stargardt's Type 1 (STGD1). This...

Boston, NY57 participantsSplice Bio

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NCT05422794Recruiting

Testing the Addition of Anti-Cancer Drug, ZEN003694 (ZEN-3694) and PD-1 Inhibitor (Pembrolizumab), to Standard Chemotherapy (Nab-Paclitaxel) Treatment in Patients With Advanced Triple-Negative Breast Cancer

This phase Ib trial tests the safety and tolerability of ZEN003694 in combination with an immunotherapy drug called pembrolizumab and the usual chemotherapy approach with nab-paclitaxel for the treatm...

Boston, NY57 participantsNational Cancer Institute (NCI)

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NCT05777512Recruiting

Randomized Controlled Crossover Trial of Postpyloric Feedings to Improve Pulmonary Outcomes in High-risk Preterm Infants

The purpose of this study is to determine if postpyloric feedings effectively improve objective measures of pulmonary health in preterm infants with chronic lung disease when compared with nasogastric...

Boston, NY50 participantsBoston Children's Hospital

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NCT06655415Recruiting

Family Members At INcreased-risk for Developing Inflammatory Bowel Disease

First-degree relatives of people with inflammatory bowel disease ("IBD," including Crohn's disease and ulcerative colitis) have an increased risk for developing IBD themselves. This study will follow ...

Boston, NY50 participantsMassachusetts General Hospital

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NCT05241418Recruiting

Atrial Late Gadolinium Enhancement in Patients with Repaired Congenital Heart Disease

In this research study the investigators want to learn more about how well the investigators can visualize scar tissue in the heart by MRI. In patients with congenital heart disease who need a procedu...

Boston, NY50 participantsBoston Children's Hospital

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NCT06645652Recruiting

Visual Arts Interventions With Older Adults

The present study investigates the feasibility, acceptability, and preliminary effects of a novel visual arts-based intervention in an older adult population. In a randomized controlled design, two ar...

Boston, NY50 participantsNortheastern University

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NCT07011810Recruiting

Axatilimab for Sclerotic Chronic Graft-versus-Host Disease

This phase II trial tests how well axatilimab works in treating patients with thickening or hardening (sclerosis) of the skin related to chronic graft-versus-host disease after a donor stem cell trans...

Boston, NY50 participantsFred Hutchinson Cancer Center

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NCT03750513Recruiting

LET Optimized IMPT in Treating Pediatric Patients With Ependymoma

This phase I trial studies the side effects of linear energy transfer (LET) optimized image modulated proton therapy (IMPT) in treating pediatric patients with ependymoma. Radiation therapy such as LE...

Boston, NY48 participantsM.D. Anderson Cancer Center

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NCT07659964Recruiting

Use of a Mobile Brain-Body Imaging Approach to Evaluate the Effects of Rhythmic Auditory Stimulation on Gait and Brain Function in Alzheimer's Disease

Alzheimer's Disease (AD) is associated with impairments in both gait and cognition, significantly increasing fall risk. Falls are a leading cause of injury-related disability in older adults, and indi...

Boston, NY40 participantsBoston University Charles River Campus

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NCT04789148Recruiting

Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency

This is a randomized, double-blind, placebo-controlled crossover pilot study of single-dose intranasal oxytocin (6 IU and 24 IU) vs. placebo in adult men and women (aged 18 years and above) with argin...

Boston, NY40 participantsElizabeth Austen Lawson

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NCT05779423Recruiting

Cryoablation+Ipilimumab+Nivolumab in Melanoma

The aim of this study is to find out whether the combination of two approved drugs, ipilimumab and nivolumab, in combination with cryoablation are safe and effective for participants who have an unres...

Boston, NY37 participantsMassachusetts General Hospital

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NCT05236062Recruiting

Impact of Exercise on the Complications of Corticosteroids in Patients With GVHD: the RESTART Trial

This study is about determining if an aerobic and resistance exercise intervention is feasible in patients diagnosed with acute or chronic GVHD (Graft-Versus-Host Disease) after having an allogeneic s...

Boston, NY36 participantsDana-Farber Cancer Institute

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NCT07137416Recruiting

Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

This phase I trial tests the safety, side effects, and best dose of pidnarulex in combination with trastuzumab deruxtecan in treating patients with breast cancer and other solid tumors that express va...

Boston, NY36 participantsNational Cancer Institute (NCI)

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NCT05711615Recruiting

Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma

This phase I trial tests the safety, side effects, and best dose of combination therapy with liposomal doxorubicin and peposertib in treating patients with sarcoma that has spread from where it first ...

Boston, NY30 participantsNational Cancer Institute (NCI)

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NCT07112183Recruiting

Open Label Treprostinil Raynaud's Study

Raynaud's phenomenon is a condition where the blood vessels in participants fingers and toes get too narrow when cold or stressed. This makes participants fingers and toes change colors - they might t...

Boston, NY30 participantsBrigham and Women's Hospital

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NCT05519241Recruiting

A Phase I Intravesical PPM Therapy for NMIBC

This clinical trial is to determine the safety and effectiveness of an investigational bladder cancer drug named "PLZ4-coated paclitaxel-loaded nanoscale micelle (PPM)." PPM is tiny particles that con...

Boston, NY29 participantsVA Office of Research and Development

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NCT05660369Recruiting

CARv3-TEAM-E T Cells in Glioblastoma

The goal of this research study is to determine the best dose of CARv3-TEAM-E T Cells for treating participants with glioblastoma. The name of the treatment intervention used in this research study i...

Boston, NY21 participantsMarcela V. Maus, M.D.,Ph.D.

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NCT07027748Recruiting

Feasibility Study of Prolonged Administration of Naxitamab, Irinotecan, and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma

This research is being done to investigate a treatment regimen of Irinotecan, Temozolomide, and Sargramostin, and an immunotherapy called Naxitamab and whether giving Naxitamab more slowly reduces the...

Boston, NY18 participantsSteven DuBois, MD

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NCT07128355Recruiting

Botensilimab, Balstilimab, and SBRT in Colorectal Cancer

This is a single-arm pilot feasibility study evaluating the combination of Botensilimab and Balstilimab with Radiation Therapy (RT) in Non-Microsatellite Instability High (MSI-H) or Proficient Mismatc...

Boston, NY15 participantsMassachusetts General Hospital

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NCT07572383Recruiting

Advanced Imaging to Assess the Effect of Immunosuppression on Progressive Fibrosis

The purpose of this study is to investigate how immunosuppression treatment affects measurements of active collagen deposition using \[68Ga\]CBP8 positron emission tomography (PET) and tissue injury u...

Boston, NY15 participantsPeter Caravan

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NCT07215416Recruiting

Safety and Efficacy of Mutation-targeted Precision Genetic Therapy for Ataxia-Telangiectasia (A-T)

This project aims to evaluate the safety and efficacy of precision genetic therapy for patients with Ataxia-telangiectasia (A-T), a rare neurodegenerative disease caused by mutations in the ATM gene. ...

Boston, NY10 participantsTimothy Yu

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NCT06387446Recruiting

Allogeneic Valve Transplantation

Valves will be taken from hearts donated by organ donors, and implanted into patients who need a new heart valve....

Boston, NY4 participantsBoston Children's Hospital

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About Ankylosing Spondylitis Clinical Trials in Boston

Ankylosing spondylitis is a chronic inflammatory disease primarily affecting the spine and sacroiliac joints, causing pain, stiffness, and potentially spinal fusion. It typically begins in early adulthood. Treatment includes NSAIDs, biologics (TNF and IL-17 inhibitors), and physical therapy.

There are currently 85 ankylosing spondylitis clinical trials recruiting participants in Boston, NY. These studies are seeking a combined 37,796 participants. Research is being sponsored by Boston Children's Hospital, Michael Shy, Sir Mortimer B. Davis - Jewish General Hospital and 53 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Ankylosing Spondylitis Clinical Trials in Boston — FAQ

Are there ankylosing spondylitis clinical trials in Boston?

Yes, there are 85 ankylosing spondylitis clinical trials currently recruiting in Boston, NY. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What ankylosing spondylitis treatments are being tested?

The 85 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for ankylosing spondylitis.

Data updated July 13, 2026 from ClinicalTrials.gov