112 Rheumatoid Arthritis Clinical Trials in Boston, NY (2026)

Q: Are there rheumatoid arthritis clinical trials in Boston?

Yes, there are 112 rheumatoid arthritis clinical trials currently recruiting in Boston, NY.

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Q: Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatments, medical tests, and doctor visits are provided at no cost.

Recruiting Rheumatoid Arthritis Studies in Boston

NCT05940857Recruiting

US National OCS Liver Perfusion (OLP) Registry

This Registry is a sponsor-initiated, multi-center, observational, post-approval registry with an independent academic oversight. TransMedics has contracted with United Network for Organ Sharing (UNO...

Boston, NY100,000 participantsTransMedics

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NCT03059420Recruiting

Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies

The purpose of this study is to identify genes associated with impaired development and function of the cranial nerves and brainstem, which may result in misalignment of the eyes (strabismus) and rela...

Boston, NY20,000 participantsBoston Children's Hospital

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NCT01258231Recruiting

Identification of Genomic Predictors of Adverse Events After Cardiac Surgery

This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure. Patients undergoing heart ...

Boston, NY4,000 participantsBrigham and Women's Hospital

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NCT07280065Recruiting

REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool

The goal of the REVEAL PTSD study is to test how well the Senseye DT works as a diagnostic test for Post-traumatic Stress Disorder (PTSD) in adults 18 and older who are experiencing one or more sympto...

Boston, NY1,900 participantsSenseye, Inc.

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NCT05589714Recruiting

Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants

This is an international, multicenter study with two components: Registry * A standardized genetic screening and a prospective, standardized, cross-sectional clinical data collection * Enrollment is...

Boston, NY1,500 participantsJaeb Center for Health Research

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NCT05444582Recruiting

Levonorgestrel 52 mg IUD for Emergency Contraception and Same-Day Start

This is a prospective clinical research study to test the effectiveness of the Levonorgestrel (LNG) 52 mg Intrauterine Device (IUD) for emergency contraception (EC) and same-day start use that will en...

Boston, NY1,404 participantsUniversity of Utah

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NCT06066502Recruiting

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

The goal of this interventional study is to compare standard mechanical ventilation to a lung-stress oriented ventilation strategy in patients with Acute Respiratory Distress Syndrome (ARDS). Particip...

Boston, NY1,100 participantsBeth Israel Deaconess Medical Center

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NCT04712812Recruiting

Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia

The Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia (HSP) is focused on gathering longitudinal clinical data as well as biological samples (skin and/or blood and/or sa...

Boston, NY700 participantsBoston Children's Hospital

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NCT05104710Recruiting

Intermuscular Coherence as a Biomarker for ALS

The specific aims of this study are to: 1. Determine if a painless and quick measurement of muscle activity using surface electrodes can help with the diagnosis of ALS. Specifically, we ask if a meas...

Boston, NY650 participantsUniversity of Chicago

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NCT07412470Recruiting

A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation

The purpose of this open-label, randomized, active-comparator-controlled study is to determine the efficacy and safety of frexalimab subcutaneous administrations up to 5 years compared to tacrolimus c...

Boston, NY526 participantsSanofi

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NCT06201676Recruiting

Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma Patients

The goal of this randomized clinical trial is to learn if the use of a low-dose nonsteroidal anti-inflammatory drug (NSAID), ketorolac, reduces the rate of chronic opioid use in orthopaedic polytrauma...

Boston, NY458 participantsMassachusetts General Hospital

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NCT06947538Recruiting

Stepped Care for Posttraumatic Stress Disorder Study

Less than 20% of people with PTSD receive any treatment. This study extends a program of research by the investigator focused on developing adaptive (stepped) interventions for PTSD. The adaptive inte...

Boston, NY428 participantsBoston Medical Center

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NCT06721819Recruiting

The SCOPE Trial: Sleep, Cognition, and Pain Bundle Vs. ERAS-cardiac for Postoperative Delirium

Sleep disturbances, cognitive reserve, and continuing pain and inflammation are other risk factors contributing to delirium (confusion and agitation) and neurocognitive decline (in the long term) foll...

Boston, NY406 participantsBeth Israel Deaconess Medical Center

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NCT04770519Recruiting

Genetic Studies of Strabismus, Nystagmus, and Associated Disorders

Strabismus (misalignment of the eyes) often runs in families. In this study, the investigators are looking for genetic variants associated with strabismus and nystagmus. Three types of subects will be...

Boston, NY400 participantsBoston Children's Hospital

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NCT06033196Recruiting

Tocilizumab in Lung Transplantation

This is a trial in which 350 primary lung transplant recipients will be randomized (1:1) to receive either Tocilizumab (six doses over 20 weeks) plus standard triple maintenance immunosuppression or p...

Boston, NY350 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT06910969Recruiting

Multidisciplinary Intervention for Adults With Chronic Graft-versus-host Disease

The goal of this study is to demonstrate the efficacy of a multidisciplinary group-based telehealth intervention (HORIZONS) compared to minimally enhanced usual care for improving self-management and ...

Boston, NY350 participantsMassachusetts General Hospital

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NCT05839379Recruiting

Targeted Pediatric High-Grade Glioma Therapy

The goal of this study is to perform genetic sequencing on brain tumors from children, adolescents, and young adult patients who have been newly diagnosed with a high-grade glioma. This molecular prof...

Boston, NY350 participantsNationwide Children's Hospital

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NCT06026410Recruiting

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

This first-in-human (FIH) dose-escalation and dose-validation/expansion study will assess KO-2806, a farnesyltransferase inhibitor (FTI), as a monotherapy and in combination, in adult patients with ad...

Boston, NY300 participantsKura Oncology, Inc.

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NCT06282575Recruiting

Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer

The purpose of this study is to evaluate the efficacy and safety of Zanidatamab plus CisGem (Cisplatin and Gemcitabine) with or without the addition of a programmed death protein 1/ligand-1 (PD-1/L1) ...

Boston, NY286 participantsJazz Pharmaceuticals

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NCT02860364Recruiting

Comparing Hypothermic Temperatures During Hemiarch Surgery

Hypothermic circulatory arrest is an important surgical technique, allowing complex aortic surgeries to be performed safely. Hypothermic circulatory arrest provides protection to cerebral and visceral...

Boston, NY282 participantsOttawa Heart Institute Research Corporation

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NCT07441642Recruiting

A Study to Investigate Efficacy and Safety of FWY003 Compared With Placebo in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration

To characterize the dose response relationship of FWY003 in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD)....

Boston, NY272 participantsNovartis Pharmaceuticals

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NCT07103733Recruiting

PRIMARY Ancillary Substudy

The PRIMARY trial (NCT05051033), which compares mitral valve repair (MVr) to transcatheter-edge-to-edge-repair (TEER), offers a platform for conducting mechanistic studies to develop early insights in...

Boston, NY250 participantsAnnetine Gelijns

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NCT06406790Recruiting

CraniSeal Post Approval Study

To collect post-approval data comparing the safety and effectiveness of CraniSeal Dural Sealant to DuraSeal Dural Sealant. The study has been powered specifically to determine whether the CraniSeal de...

Boston, NY224 participantsPramand LLC

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NCT06777901Recruiting

Auryon Atherectomy System With Standard Balloon Angioplasty Versus Standard Balloon Angioplasty Alone

The goal of this clinical trial is to learn if the Auryon Atherectomy System with balloon angioplasty safe and effective in treating lower limb blockages. The main question it aims to answer is: Is tr...

Boston, NY224 participantsAngiodynamics, Inc.

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NCT05953233Recruiting

School Inner City Air Study

The goal of this randomized clinical trial is to test the efficacy of high efficiency particulate air (HEPA) cleaners in reducing respiratory viral exposure and infections in elementary school classro...

Boston, NY200 participantsMassachusetts General Hospital

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NCT05354622Recruiting

Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)

The purpose of the HSP Sequencing Initiative is to better understand the role of genetics in hereditary spastic paraplegia (HSP) and related disorders. The HSPs are a group of more than 80 inherited n...

Boston, NY200 participantsBoston Children's Hospital

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NCT05267665Recruiting

Family Involvement in Treatment for PTSD (FIT-PTSD): A Brief, Feasible Method for Enhancing Outcomes, Retention, and Engagement

Although effective treatments for PTSD exist, high rates of treatment dropout and sub-optimal response rates remain common. Incorporating family members in treatment represents one avenue for improvin...

Boston, NY200 participantsVA Office of Research and Development

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NCT05475925Recruiting

A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas

This is a multicenter, first-in-human, Phase 1/2 study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and anti-tumor activity of DR-01 in adult patients with large granular ...

Boston, NY200 participantsDren Bio

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NCT06959277Recruiting

Balance4Mobility: Effects of Walkasins Use in Individuals With Peripheral Neuropathy and Balance Problems

The goal of this clinical trial is to is to test whether Walkasins can help people with peripheral neuropathy maintain their balance better. The main question it aims to answer is whether participants...

Boston, NY200 participantsRxFunction Inc.

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NCT06055608Recruiting

Advancing Transplantation Outcomes in Children

This is a pediatric kidney transplant study comparing the safety and efficacy of an immunosuppressive regimen of belatacept and sirolimus to tacrolimus and Mycophenolate Mofetil (MMF). Two hundred par...

Boston, NY200 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT06614322Recruiting

SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.

The goal of this clinical trial is to determine whether quantitative sensory testing (QST) can be used to classify participants into pain sub-groups and predict who will respond best to certain pain t...

Boston, NY190 participantsUniversity of Rochester

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NCT06153251Recruiting

A Study to Assess BMS-986453 in Participants With Relapsed and/or Refractory Multiple Myeloma

The purpose of this study is to assess BMS-986453 in participants with relapsed and/or refractory multiple myeloma (RRMM)....

Boston, NY187 participantsJuno Therapeutics, Inc., a Bristol-Myers Squibb Company

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NCT02118922Recruiting

A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia

We have developed novel Brillouin microscopy and we are testing its potential for keratoconus and ectasia diagnostics. We plan to perform axial scans of the cornea in human volunteers in order to comp...

Boston, NY168 participantsMassachusetts General Hospital

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NCT07131592Recruiting

Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction Surgery

This study aims to evaluate whether tranexamic acid (TXA), a medication that helps reduce bleeding, can decrease fluid drainage after breast reduction surgery. Participants will be randomly assigned t...

Boston, NY160 participantsMassachusetts General Hospital

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NCT05639933Recruiting

Study to Investigate the Efficacy, Safety, and Tolerability of Topical HT-001 for the Treatment of Skin Toxicities Associated With Epidermal Growth Factor Receptor Inhibitors

The goal of this clinical trial is to learn about HT-001 Topical Gel for treatment of EGFR inhibitor-induced skin toxicities. The main questions it aims to answer are: * Determine the therapeutic eff...

Boston, NY152 participantsHoth Therapeutics, Inc.

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NCT05327062Recruiting

Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment

The objective of this prospective, multicenter controlled study is to assess the feasibility of a patient-tailored implantation by creating a cloud-based pre-procedural multimodality CRT-roadmap by in...

Boston, NY150 participantsXSpline S.p.A.

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NCT06067841Recruiting

A Study to Assess BMS-986460 in Participants With Metastatic Castration-resistant Prostate Cancer

The purpose of this study is to assess the safety, tolerability, and preliminary efficacy of BMS-986460 in men with Metastatic Castration-resistant Prostate Cancer....

Boston, NY140 participantsBristol-Myers Squibb

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NCT06879041Recruiting

A Phase I Study of [225Ac]-AZD2284 in Patients With Metastatic Castration-Resistant Prostate Cancer

The main purpose of the study is to assess the safety and tolerability of AZD2284, AZD2287, and AZD2275....

Boston, NY136 participantsAstraZeneca

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NCT07104032Recruiting

IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)

The purpose of this clinical trial is to evaluate efficacy and safety of tirabrutinib alone compared with rituximab and temozolomide (R-TMZ) combination therapy in participants with Relapsed/Refractor...

Boston, NY132 participantsOno Pharmaceutical Co., Ltd.

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NCT06375044Recruiting

Study of SIM0500 Alone in Participants With Relapsed or Refractory Multiple Myeloma

This is an open-label, multicenter phase 1 clinical trial to evaluate the safety and tolerability, efficacy, and pharmacokinetics of SIM0500 in adult participants with Relapsed or Refractory Multiple ...

Boston, NY130 participantsJiangsu Simcere Pharmaceutical Co., Ltd.

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NCT05987852Recruiting

Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)

Chronic intestinal hypoxia and accompanying mucosal inflammation is a hallmark of ulcerative colitis (UC). Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen under increased atmospheric p...

Boston, NY126 participantsNorthwestern University

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NCT07315997Recruiting

The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study

Individuals with rheumatoid arthritis (RA) have up to 2x the risk of having a heart attack compared to someone without RA. The goal of this study is to identify biomarkers that can help us do a better...

Boston, NY120 participantsBrigham and Women's Hospital

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NCT06400004Recruiting

Lumason® Infusion vs. Bolus Administrations

A phase III study designed as a randomized, within-patient comparison of continuous infusion of diluted Lumason® versus the bolus administration of undiluted Lumason® for degree of LVO and assessment ...

Boston, NY106 participantsBracco Diagnostics, Inc

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NCT04033497Recruiting

Treatment Response Assessment Maps to Delineate Necrosis From Tumor After Stereotactic Radiation in Brain Metastases

This research study is investigating the value of an imaging study of the brain called an MRI (which stands for magnetic resonance imaging), utilized in unique way, to delineate whether the tumor has ...

Boston, NY101 participantsBrigham and Women's Hospital

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NCT07250061Recruiting

Self-Help Cognitive Processing Therapy (CPT)/Women Veterans Network (WoVeN) Study

Posttraumatic stress disorder (PTSD) can have significant impairment on aspects of mental well-being (MWB) including functioning, loneliness, physical health, and quality of life. There are several ev...

Boston, NY100 participantsBoston University

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NCT06665100Recruiting

PUL-042 Treatment in Patients With Parainfluenza Virus (PIV), Human Metapneumovirus (hMPV) or Respiratory Syncytial Virus (RSV)

The purpose of this research study is to try to see whether an experimental drug, PUL 042 Inhalation Solution (PUL 042), is effective in reducing the severity of lung infections in patients with hemat...

Boston, NY100 participantsPulmotect, Inc.

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NCT07305818Recruiting

NEXUS Study: A Study to Test Single and Multiple Doses of MER511 Given to Adults With Graves' Disease

The purpose of this study is to evaluate how well MER511 is tolerated and what side effects may occur in adults who have Graves' disease. The study drug will be administered either intravenously (into...

Boston, NY100 participantsMerida Biosciences

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NCT06936566Recruiting

MAGIC Ruxolitinib for aGVHD

This clinical trial will study ruxolitinib-based treatment of acute graft-versus-host-disease (GVHD) that developed following allogeneic hematopoietic cell transplant. Acute GVHD occurs when donor cel...

Boston, NY98 participantsJohn Levine

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NCT06713382Recruiting

Evaluating the Efficacy and Safety of Saline Irrigation as an Add-On Therapy for Retained Pleural Infections [LYTICS +]

The purpose of this protocol is to conduct a pilot prospective non-blind clinical trial to evaluate the efficacy and safety of a novel saline irrigation technique as an adjunct to standard interventio...

Boston, NY96 participantsBeth Israel Deaconess Medical Center

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NCT06753916Recruiting

ExCrossV Multi Site Trial for Vascularized High Risk Keratoplasty

The main objective of this study is to determine the safety of Ex Vivo Cross Linking (CXL) of donor corneal tissue in participants who have undergone high-risk penetrating keratoplasty....

Boston, NY96 participantsMassachusetts Eye and Ear Infirmary

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NCT06751992Recruiting

Neurocognitive Function Changes With Extended-Release Tacrolimus Among Older Kidney Transplant Recipients

The objective of this randomized controlled study is to assess the neurocognitive outcomes between individuals using immediate-release (IR) tacrolimus (Prograf®) and those who were converted to extend...

Boston, NY92 participantsMassachusetts General Hospital

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NCT07244263Recruiting

A Study of Zasocitinib in Adults With Hidradenitis Suppurativa

Hidradenitis Suppurativa (HS) is a skin condition that causes deep, painful bumps on the skin. These bumps usually appear in an area where the skin rubs together. They start as small bumps but may bec...

Boston, NY90 participantsTakeda

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NCT05996627Recruiting

Belumosudil for the Pre-emptive Treatment of Patients With Chronic Graft Versus Host Disease

This phase II trial compares the effect of belumosudil to a placebo in treating patients with chronic graft versus host disease. Chronic graft versus host disease remains a major complication of stem ...

Boston, NY82 participantsFred Hutchinson Cancer Center

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NCT04912531Recruiting

Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery

Patients who undergo cardiothoracic surgery often experience pain and anxiety around the time of surgery. Currently, treatments for pain and anxiety around the time of surgery include opioids and benz...

Boston, NY80 participantsMassachusetts General Hospital

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NCT06958796Recruiting

Strategic Help With Immunoglobulin to Enhance Protect Against Late Disease (CMV)

This study is being done to find out if administering CytoGam® after the end of standardly prescribed preventive antiviral treatment can help transplant recipients with a high risk for developing late...

Boston, NY80 participantsCamille N. Kotton, MD

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NCT06812247Recruiting

Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries

Animal assisted therapy (AAT) with dogs has been shown to be beneficial for a wide range of patients with both acute and chronic illnesses, including spinal cord injuries, heart failure, myocardial in...

Boston, NY80 participantsBoston Medical Center

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NCT06043674Recruiting

A Ph2 Study of Glofitamab Alone or With Polatuzumab Vedotin, Pirtobrutinib, or Atezolizumab in Richter's Transformation

This research is being done to evaluate Glofitamab by itself or in combination with Polatuzumab Vedotin, Pirtobrutinib, or Atezolizumab as possible treatments for Chronic Lymphocytic Leukemia (CLL) th...

Boston, NY70 participantsChristine Ryan

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NCT06660667Recruiting

A Safety and Efficacy Study of One-time SAR402663 in Adults With Neovascular Age-related Macular Degeneration

This is a Phase 1/Phase 2 multicenter study to evaluate the safety and efficacy of a one-time single-eye intravitreal dose of SAR402663 in participants with neovascular age-related macular degeneratio...

Boston, NY66 participantsSanofi

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NCT07015242Recruiting

A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma

The purpose of this study is to evaluate the safety and efficacy of lisocabtagene maraleucel (Breyanzi/liso-cel/BMS-986387) in adults as first-line treatment in transplant-ineligible Primary Central N...

Boston, NY65 participantsJuno Therapeutics, Inc., a Bristol-Myers Squibb Company

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NCT05327465Recruiting

Exercise to Enhance Cardiovascular Health Among Black Prostate Cancer Patients With Androgen Deprivation Therapy

The purpose of this research is to determine whether a 16-week culturally tailored, technology-based, aerobic and resistance exercise intervention improves cardiovascular risk factors in Black men dia...

Boston, NY62 participantsDana-Farber Cancer Institute

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NCT02271243Recruiting

Using Microbial Genomics to Elucidate the Source of Central-line Associated Bloodstream Infections

Central line-associated bloodstream infections (CLABSIs) are the most common healthcare-associated infection in children and are associated with morbidity and mortality. This study will attempt to ide...

Boston, NY60 participantsBoston Children's Hospital

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NCT06161974Recruiting

Study of Olutasidenib and Temozolomide in HGG

The goal of this study is to determine the efficacy of the study drug olutasidenib to treat newly diagnosed pediatric and young adult patients with a high-grade glioma (HGG) harboring an IDH1 mutation...

Boston, NY60 participantsRigel Pharmaceuticals

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NCT06721689Recruiting

PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors

The phase 1 primary objective is to determine the pediatric recommended phase 2 dose (RP2D) of PEEL-224 as a single agent (phase 1A) and in combination with vincristine and temozolomide (phase 1B). Th...

Boston, NY59 participantsTheodore Laetsch

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NCT05465174Recruiting

Tovorafenib for Treatment of Craniopharyngioma in Children and Young Adults

The current study assesses the tolerability and efficacy of monotherapy with pan-RAF-kinase (Tovorafenib) inhibition for the treatment of children and young adults with craniopharyngioma....

Boston, NY57 participantsSabine Mueller, MD, PhD

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NCT06088303Recruiting

Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication

The purpose of this clinical trial is to learn whether existing treatments for posttraumatic stress disorder (PTSD) can be improved. Two treatments for PTSD, cognitive processing therapy (CPT) and pro...

Boston, NY54 participantsBoston University

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NCT06761170Recruiting

Spray Cryotherapy for the Management of Benign Central Airway Stenosis (Cryo-BAS)

The goal of this clinical trial is to compare spray cryotherapy plus balloon dilatation versus current standard of Care (SoC - steroid injection, radial cuts and balloon dilatation) in patients with b...

Boston, NY50 participantsBeth Israel Deaconess Medical Center

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NCT04928677Recruiting

A Study of Codrituzumab in Children and Young Adults With Solid Tumors and Have Not Responded to Treatment or Have Come Back After Treatment

The purpose of this study to find out whether codrituzumab is a safe treatment that causes few or mild side effects in children and young adults who have solid tumors that express the protein GPC3. Th...

Boston, NY50 participantsMemorial Sloan Kettering Cancer Center

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NCT07011810Recruiting

Axatilimab for Sclerotic Chronic Graft-versus-Host Disease

This phase II trial tests how well axatilimab works in treating patients with thickening or hardening (sclerosis) of the skin related to chronic graft-versus-host disease after a donor stem cell trans...

Boston, NY50 participantsFred Hutchinson Cancer Center

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NCT06201416Recruiting

Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis

This study will test the safety and effects of SBT777101 when given as a single dose to subjects with rheumatoid arthritis. It is the first study of this treatment being done in humans. Increasing dos...

Boston, NY48 participantsSonoma Biotherapeutics, Inc.

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NCT06619561Recruiting

A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)

The purpose of this study is to determine if vimseltinib is safe, tolerable and works effectively to treat adults with active moderate to severe cGVHD. Participants will be treated with vimseltinib in...

Boston, NY48 participantsDeciphera Pharmaceuticals, LLC

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NCT05419492Recruiting

A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome

ENDEAVOR is a Phase 1/2, 2-part, multicenter study to evaluate the safety and efficacy of ETX101 in participants with SCN1A-positive Dravet syndrome aged ≥6 to \<36 months (Part 1) and aged ≥6 to \<48...

Boston, NY47 participantsEncoded Therapeutics

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NCT07193524Recruiting

Assessment of the Feasibility of Using a Preoperative Surgical Fracture Analysis Tool

This study aims to evaluate a preoperative fracture analysis tool that uses 3D visualization and biomechanical modeling to assist surgeons in planning screw and plate fixation for complex tibial plate...

Boston, NY40 participantsBrigham and Women's Hospital

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NCT07614906Recruiting

Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage

The goal of this observational study is to understand if angiographic cerebral vasospasm (CV) can be predicted by levels of nitric oxide (NO) consumption in patients with aneurysmal subarachnoid hemor...

Boston, NY40 participantsMassachusetts General Hospital

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NCT05705024Recruiting

Efficacy of Locally Delivered Allogeneic Mesenchymal Stromal Cells

The proposed Conventional Cohort Expansion Study involves the use of Mesenchymal Stromal Cells (MSCs) are derived from the bone marrow. We previously studied the safety of subconjunctival injection of...

Boston, NY38 participantsUniversity of Illinois at Chicago

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NCT05236062Recruiting

Impact of Exercise on the Complications of Corticosteroids in Patients With GVHD: the RESTART Trial

This study is about determining if an aerobic and resistance exercise intervention is feasible in patients diagnosed with acute or chronic GVHD (Graft-Versus-Host Disease) after having an allogeneic s...

Boston, NY36 participantsDana-Farber Cancer Institute

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NCT06798012Recruiting

A Study of TAK-411 in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

CIDP is an autoimmune disease. This means that the body's germ fighting (immune) system attacks itself. In CIDP, the immune system attacks the protective covering around the nerves called myelin. Over...

Boston, NY36 participantsTakeda

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NCT05287126Recruiting

A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis

The purpose of this study is to determine the safety, efficacy, and pharmacokinetics (PK) of etrasimod for the treatment of moderately to severely active ulcerative colitis in adolescents (≥ 12 years ...

Boston, NY36 participantsPfizer

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NCT07123038Recruiting

A Long-Term Follow-Up Observational Study to Evaluate Safety in Subjects Who Have Received a Gene-Modified Regulatory T Cell (Treg) Therapeutic

To assess the emergence, type, severity, and potential causality of delayed adverse events following administration of a gene-modified Treg therapeutic....

Boston, NY36 participantsSonoma Biotherapeutics, Inc.

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NCT06109909Recruiting

Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury

The goal of this study is to complete a pilot study testing the feasibility and acceptability of low-intensity pulse-based transcranial stimulation (LIP-tES) neurofeedback intervention for reducing ph...

Boston, NY36 participantsVA Office of Research and Development

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NCT04217603Recruiting

Effect of CPAP on 6-Minute Walk Test Outcomes in Patients With ECAC

The purpose of this protocol is to perform a prospective, randomized, double-blinded, pacebo-controlled clinical trial to determine the influence of a non-invasive positive pressure ventilation device...

Boston, NY32 participantsBeth Israel Deaconess Medical Center

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NCT07112183Recruiting

Open Label Treprostinil Raynaud's Study

Raynaud's phenomenon is a condition where the blood vessels in participants fingers and toes get too narrow when cold or stressed. This makes participants fingers and toes change colors - they might t...

Boston, NY30 participantsBrigham and Women's Hospital

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NCT05592015Recruiting

Ruxolitinib for the Treatment of T-Cell Large Granular Lymphocytic Leukemia

This phase II trial tests whether ruxolitinib works to shrink tumors in patients with T-cell large granular lymphocyte leukemia. Ruxolitinib may stop the growth of cancer cells by blocking some of the...

Boston, NY30 participantsJonathan Brammer

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NCT04029337Recruiting

An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System

Study to evaluate the feasibility, safety and performance of the HighLife trans-septal Transcatheter Mitral Valve in patients with moderate-severe and severe mitral regurgitation who are at high risk ...

Boston, NY30 participantsHighLife SAS

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NCT06983730Recruiting

The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response

The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers. The main questions it aims to answer are: * How do the chemical...

Boston, NY28 participantsBeth Israel Deaconess Medical Center

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NCT06623110Recruiting

Phase II Study of RP2 as Immunoprevention in High-Risk Oral Precancerous Disease

The goal of this study is to understand the safety, tolerability, and potential efficacy of an injected immune therapy called RP2 to treat oral precancer conditions and prevent progression to an oral ...

Boston, NY25 participantsGlenn J. Hanna

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NCT05103566Recruiting

Safety, Feasibility, and Efficacy of Non-invasive Vagus Nerve Stimulation (nVNS) in the Treatment of Aneurysmal Subarachnoid Hemorrhage

This is a single-site, single-arm, open-label pilot study assessing the safety, feasibility, and efficacy of non-invasive vagus nerve stimulation (nVNS), gammaCore, for the acute treatment of aneurysm...

Boston, NY25 participantsMassachusetts General Hospital

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NCT06848140Recruiting

Using Non-invasive Brain Stimulation to Treat Word Finding Difficulty in Chronic Traumatic Brain Injury

The purpose of this study is to learn more about how brain stimulation affects word finding problems in people who have a traumatic brain injury (TBI). The type of brain stimulation used is called tra...

Boston, NY24 participantsBeth Israel Deaconess Medical Center

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NCT05085210Recruiting

Improving Visual Field Deficits With Noninvasive Brain Stimulation

This is a randomized, pilot interventional study in participants with visual field deficit (VFD) caused by cortical lesion. Damage to the primary visual cortex (V1) causes a contra-lesional, homonymou...

Boston, NY24 participantsBeth Israel Deaconess Medical Center

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NCT04735263Recruiting

Dark Adaptation as an Early Indicator of Response to Statin Therapy for Intermediate AMD

interventional trial for off label use of high dose atorvastatin 80 mg in intermediate AMD patients and correlate recovery response measured by dark adaptation recovery time with drusen volume reducti...

Boston, NY21 participantsMassachusetts Eye and Ear Infirmary

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NCT06376162Recruiting

Ziftomenib in Combination With Chemotherapy for Children With Relapsed/Refractory Acute Leukemia

The primary objective of the study is to determine the recommended phase 2 dose (RP2D) of ziftomenib in combination with chemotherapy (FLA) in children with relapsed or refractory KMT2A-r, NUP98-r, or...

Boston, NY20 participantsPedAL BCU, LLC

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NCT05066178Recruiting

Speech Treatment for Minimally Verbal Children With ASD and CAS

Comorbid Childhood Apraxia of Speech (CAS) may be one factor that limits speech development in some minimally verbal children with autism. CAS is a disorder affecting speech movement planning. This st...

Boston, NY20 participantsMGH Institute of Health Professions

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NCT05642455Recruiting

SPEARHEAD-3 Pediatric Study

This is a pediatric basket study to investigate the safety and efficacy of afamitresgene autoleucel in HLA-A\*02 eligible and MAGE-A4 positive subjects aged 2-17 years of age with advanced cancers....

Boston, NY20 participantsAdaptimmune

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NCT05335434Recruiting

Intraoral Photobiomodulation Therapy to Prevent Oral Mucositis in Patients Undergoing Hematopoietic Cell Transplantation

This is a single center pilot study evaluating intraoral photobiomodulation for the prevention of oral mucositis in patients undergoing myeloablative allogeneic hematopoietic cell transplantation (all...

Boston, NY20 participantsDana-Farber Cancer Institute

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NCT06333899Recruiting

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

The goal of this study is to determine the response of the study drug loratinib in treating children who are newly diagnosed high-grade glioma with a fusion in ALK or ROS1. It will also evaluate the s...

Boston, NY15 participantsNationwide Children's Hospital

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NCT06063850Recruiting

AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy

The main goals of this clinical study are to learn if AMT-260 is safe and tolerable and works to reduce the frequency of seizures in adults with unilateral mesial temporal lobe epilepsy (MTLE)....

Boston, NY12 participantsUniQure Biopharma B.V.

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NCT04135807Recruiting

Implantable Microdevice In Primary Brain Tumors

This pilot study will assess the safety and feasibility of using an implantable microdevice to measure local intratumor response to chemotherapy and other clinically relevant drugs in malignant brain ...

Boston, NY12 participantsOliver Jonas

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NCT07287397Recruiting

Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS

PIONEER-ALS is a Phase 1/2, multicenter, open-label, ascending dose, uncontrolled, first-in-human study that will evaluate the safety, tolerability and effects on clinical and biomarker endpoints of i...

Boston, NY12 participantsVector Y Therapeutics

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NCT06690060Recruiting

Mind Body Intervention for Chronic Migraine Headaches

The goal of this exploratory study is to test a mind-body interventional approach for the treatment of chronic migraines. The main goal is to obtain feasibility information on the protocol which has b...

Boston, NY10 participantsBeth Israel Deaconess Medical Center

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NCT06511934Recruiting

Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01)

People with brainstem stroke, advanced amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), or other disorders can become unable to move or speak despite being awake and alert. In ...

Boston, NY6 participantsLeigh R. Hochberg, MD, PhD.

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NCT07357428Recruiting

Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)

The Connect-One Study is an early feasibility study to obtain preliminary device safety information for the Connexus Brain-Computer Interface (BCI). The Connexus BCI is intended to be used as: (1) an ...

Boston, NY2 participantsParadromics

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NCT05917522Recruiting

Assessment of Biomarker-Guided CNI Substitution In Kidney Transplantation

800 adult first time kidney transplant recipients will be enrolled in the Observational Study and followed to evaluate their Human Leukocyte Antigen (HLA)-DR/DQ molecular mismatch (mMM) score as a ris...

Boston, NY800 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT05009992Recruiting

Combination Therapy for the Treatment of Diffuse Midline Gliomas

This phase II trial determines if the combination of ONC201 with different drugs, panobinostat or paxalisib, is effective for treating participants with diffuse midline gliomas (DMGs). Despite years o...

Boston, NY360 participantsUniversity of California, San Francisco

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NCT04787042Recruiting

Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067

This is a multiphase, multicenter study, which includes a Phase 1a open-label, dose escalation monotherapy study of ST-067 given as an SC injection with or without obinutuzumab \[Gazyva®\] pre-treatme...

Boston, NY316 participantsSimcha IL-18, Inc.

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NCT04899908Recruiting

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

The purpose of this study is to determine whether AGuIX (Activation and Guidance of Irradiation by X-ray) gadolinium-based nanoparticles make radiation work more effectively in the treatment of patien...

Boston, NY134 participantsDana-Farber Cancer Institute

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NCT05843253Recruiting

Study of Ribociclib and Everolimus in HGG and DIPG

The goal of this study is to determine the efficacy of the study drugs ribociclib and everolimus to treat pediatric and young adult patients newly diagnosed with a high-grade glioma (HGG), including D...

Boston, NY120 participantsNationwide Children's Hospital

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NCT05096481Recruiting

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

This study will address the question of whether targeting CMV antigens with PEP-CMV can serve as a novel immunotherapeutic approach in pediatric patients with newly-diagnosed high-grade glioma (HGG) o...

Boston, NY120 participantsNationwide Children's Hospital

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NCT04877288Recruiting

A Study to Evaluate the Benefits and Risks of Conversion of Existing Adolescent Kidney Transplant Recipients Aged 12 to <18 Years to a Belatacept-based Immunosuppressive Regimen as Compared to Continuation of a Calcineurin Inhibitor-based Regimen, and Their Adherence to Immunosuppressive Medications

The purpose of this study is to evaluate the benefits and risks of conversion of existing adolescent kidney allograft recipients aged 12 to less than 18 years of age to a belatacept-based immunosuppre...

Boston, NY102 participantsBristol-Myers Squibb

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NCT05986864Recruiting

Phase I/II Study of SKG0106 Intravitreal Injection in Patients With Neovascular Age-related Macular Degeneration (nAMD)

This is a phase 1/2 clinical study to evaluate the safety, preliminary efficacy, immunogenicity, and pharmacokinetic (PK) characteristics of SKG0106 in subjects with nAMD. Based on results from the ph...

Boston, NY68 participantsSkyline Therapeutics (US) Inc.

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NCT05191706Recruiting

Evaluate the Safety of DEXYCU for the Treatment of Inflammation Following Ocular Surgery for Childhood Cataract

A Phase 3/4, Prospective, Randomized, Active Treatment-Controlled, Parallel-Design, Multicenter Study to Evaluate the Safety of DEXYCUfor the Treatment of Inflammation Following Ocular Surgery for Chi...

Boston, NY60 participantsEyePoint Pharmaceuticals, Inc.

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NCT05922761Recruiting

BElumosudil for Bronchiolitis Obliterans Prevention/Therapy (BEBOP)

The goal of this research study is to test the efficacy of a novel immunosuppressive agent, belumosudil, in allogeneic hematopoietic stem cell transplant (HSCT) recipients who have been newly diagnose...

Boston, NY45 participantsDana-Farber Cancer Institute

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NCT05819866Recruiting

A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy

A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adults Male Subjects with Cerebral Adrenoleukodystrophy....

Boston, NY40 participantsMinoryx Therapeutics, S.L.

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NCT04906096Recruiting

Paxalisib (GDC-0084) In Recurrent Or Refractory PCNSL

This research study is studying a drug called Paxalisib (GDC-0084) as a possible treatment for primary central nervous system lymphoma (PCNSL)...

Boston, NY25 participantsLakshmi Nayak, MD

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About Rheumatoid Arthritis Clinical Trials in Boston

Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting approximately 1.3 million Americans, where the immune system mistakenly attacks joint linings, causing painful swelling, bone erosion, and joint deformity. Early diagnosis and treatment are critical to prevent irreversible damage. Current standard treatments include methotrexate and other DMARDs, TNF inhibitors (etanercept, infliximab), IL-6 inhibitors (tocilizumab), T-cell costimulation modulators (abatacept), and JAK inhibitors (tofacitinib, baricitinib). Clinical trials are now exploring next-generation targeted therapies, dual-pathway inhibitors, and treatment strategies aimed at achieving sustained remission rather than just symptom control. Patients with inadequate response to conventional DMARDs or biologics are commonly eligible for enrollment.

There are currently 112 rheumatoid arthritis clinical trials recruiting participants in Boston, NY. These studies are seeking a combined 144,404 participants. Research is being sponsored by TransMedics, Boston Children's Hospital, Brigham and Women's Hospital and 66 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Rheumatoid Arthritis Clinical Trials in Boston — FAQ

Are there rheumatoid arthritis clinical trials in Boston?

Yes, there are 112 rheumatoid arthritis clinical trials currently recruiting in Boston, NY. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What rheumatoid arthritis treatments are being tested?

The 112 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for rheumatoid arthritis.

Data updated July 13, 2026 from ClinicalTrials.gov