41 Brain Cancer Clinical Trials in Boston, NY (2026)

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Recruiting Brain Cancer Studies in Boston

NCT06146738Recruiting

The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203)

There is no consensus on the optimal treatment of patients with high-grade glioma, especially when patients have limited functioning performance at presentation (KPS ≤70). Therefore, there are varied ...

Boston, NY1,015 participantsJasper Gerritsen

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NCT06118723Recruiting

The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)

A greater extent of resection of the contrast-enhancing (CE) tumor part has been associated with improved outcomes in high-grade glioma patients. Recent results suggest that resection of the non-contr...

Boston, NY784 participantsJasper Gerritsen

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NCT06146725Recruiting

The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)

There are no guidelines or prospective studies defining the optimal surgical treatment for gliomas of older patients (≥70 years) or those with limited functioning performance at presentation (KPS ≤70)...

Boston, NY564 participantsJasper Gerritsen

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NCT06283927Recruiting

The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302)

Previous evidence has indicated that resection for recurrent glioblastoma might benefit the prognosis of these patients in terms of overall survival. However, the demonstrated safety profile of this a...

Boston, NY464 participantsJasper Gerritsen

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NCT02977780Recruiting

INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

This research study is studying several investigational drugs as a possible treatment for Glioblastoma (GBM). The drugs involved in this study are : * Abemaciclib * Temozolomide (temodar) * Neratini...

Boston, NY460 participantsPatrick Wen, MD

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NCT04708171Recruiting

The PROGRAM-study: Awake Mapping Versus Asleep Mapping Versus No Mapping for Glioblastoma Resections

The study is designed as an international, multicenter prospective cohort study. Patients with presumed glioblastoma (GBM) in- or near eloquent areas on diagnostic MRI will be selected by neurosurgeon...

Boston, NY453 participantsErasmus Medical Center

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NCT05009992Recruiting

Combination Therapy for the Treatment of Diffuse Midline Gliomas

This phase II trial determines if the combination of ONC201 with different drugs, panobinostat or paxalisib, is effective for treating participants with diffuse midline gliomas (DMGs). Despite years o...

Boston, NY360 participantsUniversity of California, San Francisco

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NCT05839379Recruiting

Targeted Pediatric High-Grade Glioma Therapy

The goal of this study is to perform genetic sequencing on brain tumors from children, adolescents, and young adult patients who have been newly diagnosed with a high-grade glioma. This molecular prof...

Boston, NY350 participantsNationwide Children's Hospital

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NCT03761121Recruiting

Developing Fast Pediatric Imaging

This research study is evaluating the investigational software for magnetic resonance imaging (MRI) systems and techniques to process magnetic resonance (MR) images...

Boston, NY300 participantsBoston Children's Hospital

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NCT01356290Recruiting

Antiangiogenic Therapy for Children with Recurrent Medulloblastoma, Ependymoma and ATRT

Patients with relapsed medulloblastoma, ependymoma and ATRT have a very poor prognosis whether treated with conventional chemotherapy, high-dose chemotherapy with stem cell rescue, irradiation or comb...

Boston, NY232 participantsMedical University of Vienna

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NCT06273176Recruiting

The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma

Resection of glioblastoma in or near functional brain tissue is challenging because of the proximity of important structures to the tumor site. To pursue maximal resection in a safe manner, mapping me...

Boston, NY225 participantsErasmus Medical Center

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NCT06805305Recruiting

DOC1021 Dendritic Cell Immunotherapy for Treatment of Newly Diagnosed Adult Glioblastoma (GBM)

The goal of this clinical trial is to learn if DOC1021 + pIFN alongside standard of care (SOC) will improve survival in adult patients newly diagnosed with glioblastoma (IDH-wt). It will also evaluate...

Boston, NY180 participantsDiakonos Oncology Corporation

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NCT03423628Recruiting

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

This study will test an investigational drug called AZD1390 in combination with radiation therapy for the treatment of brain tumors. This is the first time AZD1390 is being given to patients. This stu...

Boston, NY180 participantsAstraZeneca

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NCT07326566Recruiting

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

The purpose of this study is to see if combining silevertinib with temozolomide after surgery and radiotherapy helps treat newly diagnosed glioblastoma (GBM) better than using temozolomide alone in th...

Boston, NY162 participantsBlack Diamond Therapeutics, Inc.

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NCT04188535Recruiting

Serial MRI Scans During Radiation Therapy

This is a phase 1 study to determine the feasibility and utility of using serial magnetic resonance imaging (MRI) to assess treatment response during and after radiation therapy (standard of care canc...

Boston, NY149 participantsDana-Farber Cancer Institute

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NCT04775485Recruiting

A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

This is a Phase 2, multi center, open-label study to evaluate the safety and efficacy of Type II RAF (tovorafenib) in pediatric participants with low-grade glioma or advanced solid tumors. Qualifying ...

Boston, NY141 participantsDay One Biopharmaceuticals, Inc.

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NCT04899908Recruiting

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

The purpose of this study is to determine whether AGuIX (Activation and Guidance of Irradiation by X-ray) gadolinium-based nanoparticles make radiation work more effectively in the treatment of patien...

Boston, NY134 participantsDana-Farber Cancer Institute

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NCT05096481Recruiting

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

This study will address the question of whether targeting CMV antigens with PEP-CMV can serve as a novel immunotherapeutic approach in pediatric patients with newly-diagnosed high-grade glioma (HGG) o...

Boston, NY120 participantsNationwide Children's Hospital

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NCT05843253Recruiting

Study of Ribociclib and Everolimus in HGG and DIPG

The goal of this study is to determine the efficacy of the study drugs ribociclib and everolimus to treat pediatric and young adult patients newly diagnosed with a high-grade glioma (HGG), including D...

Boston, NY120 participantsNationwide Children's Hospital

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NCT07225621Recruiting

Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

The purpose of this research is to test an investigational device using ultrasound along with an investigational drug to see if it is useful in treating glioblastoma following standard of care therapy...

Boston, NY103 participantsAlpheus Medical, Inc.

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NCT04033497Recruiting

Treatment Response Assessment Maps to Delineate Necrosis From Tumor After Stereotactic Radiation in Brain Metastases

This research study is investigating the value of an imaging study of the brain called an MRI (which stands for magnetic resonance imaging), utilized in unique way, to delineate whether the tumor has ...

Boston, NY101 participantsBrigham and Women's Hospital

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NCT06099743Recruiting

ASCENT Intervention for Brain Tumor Patients

The goal of this study is to refine and test a psychosocial intervention called ASCENT (ACT-based Supportive intervention for patients with CENTral nervous system tumors). This intervention was develo...

Boston, NY100 participantsMassachusetts General Hospital

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NCT03286335Recruiting

Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy

This research study is studying Proton Radiation as a possible treatment for brain tumor. The radiation involved in this study is: -Proton Radiation...

Boston, NY100 participantsMassachusetts General Hospital

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NCT05463848Recruiting

Surgical Pembro +/- Olaparib w TMZ for rGBM

This research study is studying a combination therapy as a possible treatment for recurrent glioblastoma (GBM), a brain tumor that is growing or progressing despite earlier treatment. The names of th...

Boston, NY78 participantsL. Nicolas Gonzalez Castro, MD, PhD

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NCT06161974Recruiting

Study of Olutasidenib and Temozolomide in HGG

The goal of this study is to determine the efficacy of the study drug olutasidenib to treat newly diagnosed pediatric and young adult patients with a high-grade glioma (HGG) harboring an IDH1 mutation...

Boston, NY60 participantsRigel Pharmaceuticals

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NCT06649851Recruiting

G-CSF After Chemo-radiation in Patients With Glioblastoma

This research study involves the study of granulocyte colony stimulating factor (G-CSF) in patients with MGMT-methylated glioblastoma multiforme (GBM) that are undergoing standard chemoradiation. The ...

Boston, NY60 participantsMassachusetts General Hospital

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NCT07132190Recruiting

Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction

The goal of this study is to evaluate the feasibility and effectiveness of same-day radiation planning and treatment. The study will shorten the time interval between radiation planning (radiation map...

Boston, NY60 participantsAyal A. Aizer, MD

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NCT06835803Recruiting

Enhanced Local Intensified Radiation Therapy in Elderly Glioblastoma: A Phase 2 Hybrid Randomized Trial

Glioblastoma (GBM) is an aggressive malignancy of the central nervous system. Older adults with GBM have a unique constellation of medical, psychosocial, and supportive care needs. To address these ch...

Boston, NY56 participantsBrigham and Women's Hospital

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NCT05976490Recruiting

NeuroPathways Intervention for Brain Tumor Patients

This goal of this study is to test an information and support intervention for patients with malignant (or "high-grade") brain tumors. This study was developed to help patients cope after a brain tumo...

Boston, NY50 participantsMassachusetts General Hospital

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NCT04485559Recruiting

Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

This phase I trial studies the side effects and best dose of trametinib and everolimus in treating pediatric and young adult patients with gliomas that have come back (recurrent). Trametinib acts by t...

Boston, NY50 participantsUniversity of California, San Francisco

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NCT06000787Recruiting

MCT for the Harvard/UCSF ROBIN Center

The goal of the Molecular Characterization Trial (MCT) is to obtain biological specimens and data resources from patients enrolled on prospective trials, to ensure that the Harvard/UCSF ROBIN Center a...

Boston, NY47 participantsBrigham and Women's Hospital

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NCT02896335Recruiting

Palbociclib and Pembrolizumab In Central Nervous System Metastases

This research study is studying This research study is studying the efficacy and safety of the following study drugs as a possible treatment for recurrent central nervous system (CNS) metastases: * P...

Boston, NY45 participantsMassachusetts General Hospital

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NCT05013892Recruiting

NTS-WBRT in Brain Metastases

This research is being done to assess the quality of life and symptom burden in participants who receive (normal tissue sparing whole brain radiation therapy (NTS-WBRT). This research study involves:...

Boston, NY41 participantsMassachusetts General Hospital

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NCT04943848Recruiting

rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG

This is a phase I, open label, plus expansion clinical trial evaluating the safety and tolerability of rHSC-DIPGVax in combination with BALSTILIMAB and ZALIFRELIMAB. rHSC-DIPGVax is an off-the-shelf n...

Boston, NY36 participantsAnn & Robert H Lurie Children's Hospital of Chicago

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NCT05740839Recruiting

High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumors: A Pilot Feasibility Study

The purpose of this study is to determine whether a 16-week virtual, home-based, high-intensity interval training (HIIT) exercise program will improve physical, cognitive, and emotional health among y...

Boston, NY30 participantsDana-Farber Cancer Institute

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NCT06552260Recruiting

A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma

This research study is studying troriluzole as a possible treatment for recurrent glioblastoma. The name of the study drug involved in this research study is: -Troriluzole (a tripeptide prodrug of r...

Boston, NY27 participantsUgonma Chukwueke

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NCT05660369Recruiting

CARv3-TEAM-E T Cells in Glioblastoma

The goal of this research study is to determine the best dose of CARv3-TEAM-E T Cells for treating participants with glioblastoma. The name of the treatment intervention used in this research study i...

Boston, NY21 participantsMarcela V. Maus, M.D.,Ph.D.

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NCT06917885Recruiting

CUE-102 in Recurrent Glioblastoma

The goal of this study is to evaluate the safety of the experimental drug, CUE-102, and establish the recommended dose of CUE-102 for participants with Recurrent Glioblastoma (GBM). The name of the s...

Boston, NY18 participantsDavid Reardon, MD

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NCT04655404Recruiting

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

This is a pilot study that will evaluate disease status in children that have been newly diagnosed high-grade glioma with TRK fusion. The evaluation will occur after 2 cycles of the medication (Larotr...

Boston, NY15 participantsNationwide Children's Hospital

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NCT06333899Recruiting

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

The goal of this study is to determine the response of the study drug loratinib in treating children who are newly diagnosed high-grade glioma with a fusion in ALK or ROS1. It will also evaluate the s...

Boston, NY15 participantsNationwide Children's Hospital

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NCT04135807Recruiting

Implantable Microdevice In Primary Brain Tumors

This pilot study will assess the safety and feasibility of using an implantable microdevice to measure local intratumor response to chemotherapy and other clinically relevant drugs in malignant brain ...

Boston, NY12 participantsOliver Jonas

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About Brain Cancer Clinical Trials in Boston

Brain cancer includes tumors that originate in the brain (primary) or spread from other areas (metastatic). Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Treatment typically combines surgery, radiation, and chemotherapy, with immunotherapy trials underway.

There are currently 41 brain cancer clinical trials recruiting participants in Boston, NY. These studies are seeking a combined 7,518 participants. Research is being sponsored by Jasper Gerritsen, Patrick Wen, MD, Erasmus Medical Center and 20 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Brain Cancer Clinical Trials in Boston — FAQ

Are there brain cancer clinical trials in Boston?

Yes, there are 41 brain cancer clinical trials currently recruiting in Boston, NY. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What brain cancer treatments are being tested?

The 41 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for brain cancer.

Data updated July 13, 2026 from ClinicalTrials.gov