7 Esophageal Cancer Clinical Trials in New York, NY (2026)

Q: How do I join a clinical trial in New York?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the New York research site will contact you.

Recruiting Esophageal Cancer Studies in New York

NCT05706558Recruiting

Retrospective Review of Esophageal Cancer at MSKCC

Residual tumor at the proximal or distal margin after esophagectomy is a known prognostic factor for poor survival outcomes in patients with esophageal cancer; however, the significance of the circumf...

New York, NY4,000 participantsMemorial Sloan Kettering Cancer Center

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NCT05319730Recruiting

A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)

This is a Phase 1/2, multicenter, randomized, open-label umbrella platform study to evaluate the safety and efficacy of investigational agents with or without pembrolizumab and/or chemotherapy, for th...

New York, NYPHASE1230 participantsMerck Sharp & Dohme LLC

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NCT06445972Recruiting

Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)

This is a phase 1/2 multicenter, open-label umbrella platform study that will evaluate the safety and efficacy of sacituzumab tirumotecan (MK-2870) plus paclitaxel versus ramucirumab plus paclitaxel, ...

New York, NYPHASE1210 participantsMerck Sharp & Dohme LLC

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NCT06469944Recruiting

Substudy 06C: A Study of Sacituzumab Tirumotecan (MK-2870) With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)

This is a phase 1/2, multicenter, open-label umbrella platform study that will evaluate the safety and tolerability of sacituzumab tirumotecan with pembrolizumab and fluoropyrimidine chemotherapy for ...

New York, NYPHASE1160 participantsMerck Sharp & Dohme LLC

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NCT07284186Recruiting

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

A multicenter, single-arm, first-in-human study to investigate the safety, pharmacokinetics, and preliminary antitumor activity of PLX-61639 in participants with locally advanced or metastatic, relaps...

New York, NYPHASE1155 participantsPlexium, Inc.

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NCT06123338Recruiting

A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

The purpose of this study to find out whether adding trastuzumab and pembrolizumab to standard chemotherapy is an effective treatment for resectable HER2+ esophagogastric cancer....

New York, NYPHASE249 participantsMemorial Sloan Kettering Cancer Center

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NCT06340711Recruiting

Study of Suratadenoturev (OBP-301) in Combination With Pembrolizumab in Esophagogastric Adenocarcinoma

The goal of this study is to learn about of the research study drug, telomelysin (OBP-301), in combination with pembrolizumab in advanced or metastatic gastric or gastroesophageal junction (GEJ) cance...

New York, NYPHASE227 participantsWeill Medical College of Cornell University

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About Esophageal Cancer Clinical Trials in New York

Esophageal cancer occurs in the esophagus, the tube connecting the throat to the stomach. The two main types are squamous cell carcinoma and adenocarcinoma. Treatment may include surgery, chemotherapy, radiation, and immunotherapy.

There are currently 7 esophageal cancer clinical trials recruiting participants in New York, NY. These studies are seeking a combined 4,831 participants. Research is being sponsored by Memorial Sloan Kettering Cancer Center, Merck Sharp & Dohme LLC, Plexium, Inc. and 1 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Esophageal Cancer Clinical Trials in New York — FAQ

Are there esophageal cancer clinical trials in New York?

Yes, there are 7 esophageal cancer clinical trials currently recruiting in New York, NY. Browse the studies on this page to find one that fits.

How do I join a clinical trial in New York?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the New York research site will contact you about next steps.

Are clinical trials in New York free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many New York studies also compensate for your time and travel.

What esophageal cancer treatments are being tested?

The 7 active trials in New York are testing new therapies including novel drugs, biologics, and treatment approaches for esophageal cancer.

Data updated July 18, 2026 from ClinicalTrials.gov