12 Major Depressive Disorder Clinical Trials in New York, NY (2026)

Q: How do I join a clinical trial in New York?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the New York research site will contact you.

Recruiting Major Depressive Disorder Studies in New York

NCT05800925Recruiting

Triage Survey for Psychiatry Research Eligibility

TRIAGE-Psych is a survey study designed to assess potential participants' eligibility to screen for industry-sponsored psychiatry clinical trials....

New York, NY20,000 participantsAdams Clinical

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NCT05573074Recruiting

Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33

The purpose of this research study is to determine if application of near infrared energy to the forehead can change blood flow in the brains of people with depression. Near infrared energy is like li...

New York, NYNA120 participantsNYU Langone Health

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NCT06213324Recruiting

Neural Circuit Effects of Ketamine in Depression

This project is designed to examine the role of the subgenual anterior cingulate cortex (sgACC) in anhedonia and anxiety in humans with depression, as well as the acute and sustained effects of ketami...

New York, NYPHASE4120 participantsIcahn School of Medicine at Mount Sinai

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NCT06938841Recruiting

Maintenance rTMS for Depression (Maitr-De)

Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising intervention for treatment-resistant depression (TRD), yet substantial uncertainties persist regarding its efficacy as a ...

New York, NYNA75 participantsUniversity of California, San Diego

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NCT06559826Recruiting

Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression

The proposed study is a single-site, randomized, controlled clinical trial (RCT) comparing ketamine-assisted psychotherapy (KAP) to a standard evidence-based regimen of ketamine administered in a medi...

New York, NYPHASE270 participantsIcahn School of Medicine at Mount Sinai

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NCT07493317Recruiting

Neutralizing Interleukin (IL)-6

The proposed study aims to establish the feasibility and safety of subcutaneous tocilizumab, a monoclonal antibody (mAb) against interleukin (IL)-6 receptor, in adults with Major Depressive Disorder (...

New York, NYPHASE260 participantsIcahn School of Medicine at Mount Sinai

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NCT06592833Recruiting

Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder

This is an interventional, parallel arm assignment treatment study in individuals with Major Depressive Disorder (MDD). Each individual will be treated with a single dose of pimavanserin or placebo pl...

New York, NYPHASE260 participantsIcahn School of Medicine at Mount Sinai

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NCT07572526Recruiting

tDCS: Sleep to Mood in Depression (S2M-D)

The purpose of this study is to determine whether changes in sleep consolidation occur during home-based transcranial direct current stimulation (tDCS) in adults with moderate depression and whether t...

New York, NYNA35 participantsNYU Langone Health

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NCT07139834Recruiting

Pattern Separation in Major Depressive Disorder

This study seeks to examine the effects of treatment with a selective serotonin reuptake inhibitor (SSRI), escitalopram, a first-line treatment for depression, in combination with placebo or with exte...

New York, NYPHASE130 participantsJeffrey Miller

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NCT07680140Recruiting

Biomarker-Guided Antidepressant Selection

Depression is one of the leading causes of disability worldwide. Common treatments like antidepressant medications and talk therapy work well for some people, but many others do not improve, even afte...

New York, NYPHASE427 participantsWeill Medical College of Cornell University

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NCT05773755Recruiting

DBS for TRD With the Medtronic Percept PC

Of the estimated 30 million Americans who suffer from Major Depressive Disorder, approximately 10% are considered treatment resistant. Deep brain stimulation (DBS) to a region of the brain called the ...

New York, NYNA20 participantsHelen Mayberg, MD

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NCT05239780Recruiting

Invasive Decoding and Stimulation of Altered Reward Computations in Depression Patients

Novel invasive neurostimulation stimulation strategies through neurosurgical interventions are emerging as a promising therapeutical strategy for major depressive disorder. These have been applied mos...

New York, NYNA10 participantsIcahn School of Medicine at Mount Sinai

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About Major Depressive Disorder Clinical Trials in New York

Major depressive disorder (MDD) is a severe form of depression characterized by persistent sadness, loss of interest, and impaired daily functioning. Treatment-resistant depression (TRD) affects patients who do not respond to standard therapies. Novel treatments like ketamine, psilocybin, and neuromodulation are being studied.

There are currently 12 major depressive disorder clinical trials recruiting participants in New York, NY. These studies are seeking a combined 20,627 participants. Research is being sponsored by Adams Clinical, NYU Langone Health, Icahn School of Medicine at Mount Sinai and 4 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Major Depressive Disorder Clinical Trials in New York — FAQ

Are there major depressive disorder clinical trials in New York?

Yes, there are 12 major depressive disorder clinical trials currently recruiting in New York, NY. Browse the studies on this page to find one that fits.

How do I join a clinical trial in New York?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the New York research site will contact you about next steps.

Are clinical trials in New York free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many New York studies also compensate for your time and travel.

What major depressive disorder treatments are being tested?

The 12 active trials in New York are testing new therapies including novel drugs, biologics, and treatment approaches for major depressive disorder.

Data updated October 18, 2026 from ClinicalTrials.gov