14 Substance Use Disorder Clinical Trials in New York, NY (2026)

Q: How do I join a clinical trial in New York?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the New York research site will contact you.

Recruiting Substance Use Disorder Studies in New York

NCT06796062Recruiting

Psilocybin for Opioid Use Disorder (OUD)

This is a double-blind, adaptive, 2-stage, multi-site, phase 2 randomized controlled clinical trial designed to evaluate effects of moderate and high dose psilocybin, relative to low-dose psilocybin c...

New York, NY480 participantsNYU Langone Health

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NCT06940674Recruiting

Adjunctive Cannabidiol for Recovery From Opioid Study

The long-term goal of the project is to determine whether cannabidiol (CBD) can reduce craving and relapse in individuals with opioid use disorder (OUD). The first phase of this project was an open cr...

New York, NY450 participantsIcahn School of Medicine at Mount Sinai

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NCT05033028Recruiting

Smartphones for Opiate Addiction Recovery

Treatments for opioid addiction exist, but effectiveness is compromised when subjects use illicit opiates during treatment. Reuse rates during treatment can be high, and reducing illicit opiate use du...

New York, NY225 participantsNYU Langone Health

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NCT06548490Recruiting

GLP-1R Agonist Treatment for Opioid Use Disorder

The goal of this clinical trial is to learn if semaglutide can reduce illicit opioid use in adults in outpatient treatment for opioid use disorder, and who are receiving either buprenorphine or methad...

New York, NY200 participantsMilton S. Hershey Medical Center

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NCT06051890Recruiting

Assessing Optimal XRB Initiation Points in Jail

This application describes a 3-year, randomized controlled trial. Eligible, consenting adults (N=200) with existing sublingual buprenorphine (SLB) prescriptions who enter Middlesex County House of Cor...

New York, NY200 participantsNYU Langone Health

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NCT06349083Recruiting

Neurobehavioral Mechanisms of Psilocybin-assisted Treatment for AUD

This is a double-blind, randomized, placebo-controlled Phase 2 mechanistic clinical trial designed to evaluate the therapeutic neural mechanisms of psilocybin in patients with alcohol use disorder (AU...

New York, NY200 participantsNYU Langone Health

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NCT05011266Recruiting

Efficacy of Buprenorphine and XR-Naltrexone Combination for Relapse Prevention in Opioid Use Disorder

This study will evaluate the effectiveness of a new pharmacological approach to increase efficacy of treatment with extended release naltrexone (XR-naltrexone) for individuals with opioid use disorder...

New York, NY180 participantsNew York State Psychiatric Institute

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NCT06573476Recruiting

Addressing Racial Disparities in Opioid Overdose Using Peer Recovery Coach Training and mHealth Platform

The study aims to adapt an existing Cultural Structural Humility (CSH) training into a video format for peer recovery coaches (PRCs) and refine an AI-driven texting tool to reinforce the training. Aft...

New York, NY180 participantsFriends Research Institute, Inc.

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NCT04084860Recruiting

The Role of Brief Potent Glutamatergic Modulation in Addressing Problem Drinking

The proposed project tests the efficacy of glutamate modulators in non-depressed individuals with alcohol use disorder (AUD); the primary hypothesis is that the glutamate modulator being tested reduce...

New York, NY120 participantsNew York State Psychiatric Institute

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NCT06496750Recruiting

Ketamine for Methamphetamine Use Disorder

This study aims to determine whether treatment response with IV ketamine is superior to treatment response with IV midazolam in adults with moderate to severe MUD. The study design is a 12-week rando...

New York, NY120 participantsUniversity of Texas Southwestern Medical Center

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NCT07322432Recruiting

The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction

This clinical trial evaluates the VapeAway system, a novel, multi-modal intervention designed to address the multifaceted nature of vaping addiction. VapeAway combines progressive nicotine tapering vi...

New York, NY70 participantsVapeAway

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NCT06793488Recruiting

Anxiety During Abstinence in AUD

The goal of this study is to better understand the underlying neurobiological basis of anxiety that emerges during abstinence in patients with alcohol use disorder (AUD). The main questions it aims to...

New York, NY60 participantsColumbia University

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NCT06726200Recruiting

A Clinical Trial Comparing Buprenorphine Formulations for High Potency Synthetic Opioid Use

The goal of this clinical trial is to compare buprenorphine formulations (sublingual buprenorphine versus long-acting injectable buprenorphine) for treating opioid use disorder among individuals who u...

New York, NY60 participantsRachel R. Luba

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NCT04458545Recruiting

Clinical Trials of Multivalent Opioid Vaccine Components

Currently, abuse of prescription opioid analgesics and heroin is a serious problem in the U.S. Although several medications, including methadone, buprenorphine, and naltrexone, are available and effec...

New York, NY45 participantsNew York State Psychiatric Institute

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About Substance Use Disorder Clinical Trials in New York

Substance use disorder is a condition where the use of substances leads to health issues, disability, and failure to meet responsibilities. It encompasses alcohol, opioid, stimulant, and other drug addictions. Treatment includes behavioral therapy, medication-assisted treatment, and support programs.

There are currently 14 substance use disorder clinical trials recruiting participants in New York, NY. These studies are seeking a combined 2,590 participants. Research is being sponsored by NYU Langone Health, Icahn School of Medicine at Mount Sinai, Milton S. Hershey Medical Center and 6 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Substance Use Disorder Clinical Trials in New York — FAQ

Are there substance use disorder clinical trials in New York?

Yes, there are 14 substance use disorder clinical trials currently recruiting in New York, NY. Browse the studies on this page to find one that fits.

How do I join a clinical trial in New York?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the New York research site will contact you about next steps.

Are clinical trials in New York free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many New York studies also compensate for your time and travel.

What substance use disorder treatments are being tested?

The 14 active trials in New York are testing new therapies including novel drugs, biologics, and treatment approaches for substance use disorder.

Data updated July 13, 2026 from ClinicalTrials.gov