10 Lupus Clinical Trials in St Louis, MO (2026)

Q: How do I join a clinical trial in St Louis?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the St Louis research site will contact you.

Recruiting Lupus Studies in St Louis

NCT06581198Recruiting

A Study of Rapcabtagene Autoleucel in Systemic Lupus Erythematosus (SLE) Patients With Active, Refractory Lupus Nephritis (LN)

The purpose of this study is to evaluate the efficacy and safety of rapcabtagene autoleucel (administered once following lymphodepletion) versus Standard of Care (SOC) in patients with systemic lupus ...

St Louis, MOPHASE2179 participantsNovartis Pharmaceuticals

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NCT06897930Recruiting

A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE

This is a Phase 1b/2, single-arm, open-label, multi-center, clinical study of AZD0120, a CD19/BCMA dual CAR T cell therapy, to evaluate the safety, tolerability, and efficacy in adult participants wit...

St Louis, MOPHASE1150 participantsAstraZeneca

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NCT04629547Recruiting

Sleep Trial to Prevent Alzheimer's Disease

The purpose of this study is to determine if treatment with the sleep aid suvorexant can decrease the rate of amyloid-β (Aβ) accumulation in the brain....

St Louis, MOPHASE2120 participantsWashington University School of Medicine

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NCT05538208Recruiting

The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study

The study is a 1-year 2-part double-blinded placebo controlled 2-arm clinical trial. Treatment arms are (1) MMF dosed as per body-surface area (MMFBSA; 600mg/m2 body surface area per dose about every ...

St Louis, MOPHASE2105 participantsChildren's Hospital Medical Center, Cincinnati

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NCT06925542Recruiting

A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease

This is a single-arm, open-label, multicenter, ascending dose Phase 1 study evaluating the safety and preliminary efficacy of CTX112 in adult subjects with refractory autoimmune diseases, including ac...

St Louis, MOPHASE180 participantsCRISPR Therapeutics

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NCT04652882Recruiting

Evaluating the Effects of Tasimelteon Vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD)

This is a multicenter, double-blind, randomized study to evaluate the efficacy and safety of a daily single oral dose of tasimelteon and matching placebo in male and female participants with DSWPD....

St Louis, MOPHASE370 participantsVanda Pharmaceuticals

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NCT07074288Recruiting

Obstructive Sleep Apnea Non-PAP Outcomes and Viable Alternatives

OSANOVA is a non-randomized clinical trial which aims to compare outcomes of mandibular advancement device (MAD) and hypoglossal nerve stimulation (HGNS) therapies in moderate-to-severe OSA patients w...

St Louis, MONA60 participantsWashington University School of Medicine

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NCT07089121Recruiting

Descartes-08 for Children, Adolescents, and Young Adults With Autoimmune Disorders

Safety, tolerability and efficacy of Descarte-08 in children, adolescents and young adults with childhood-onset systemic lupus erythematosus, ANCA-associated vasculitis, juvenile myasthenia gravis, an...

St Louis, MOPHASE150 participantsCartesian Therapeutics

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NCT07492420Recruiting

MedCline Investigational Study for the Treatment of Mild OSA With Positional Therapy

The purpose of this study is to evaluate the safety and effectiveness of the MedCline Sleep System in reducing symptoms related to mild OSA....

St Louis, MONA35 participantsAmenity Health, Inc.

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NCT07132307Recruiting

Reducing Obstructive Sleep Apnea After Hypoglossal Nerve Stimulation Through Mandibular Advancement

The purpose of this study is to evaluate the effectiveness, feasibility, and safety of mandibular advancement devices (MAD) for treating severe obstructive sleep apnea (OSA) in patients who are CPAP i...

St Louis, MONA30 participantsWashington University School of Medicine

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About Lupus Clinical Trials in St Louis

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect the joints, skin, kidneys, brain, and other organs. It is more common in women and often involves periods of flares and remission. Treatment includes antimalarials, immunosuppressants, and biologics.

There are currently 10 lupus clinical trials recruiting participants in St Louis, MO. These studies are seeking a combined 879 participants. Research is being sponsored by Novartis Pharmaceuticals, AstraZeneca, Washington University School of Medicine and 5 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Lupus Clinical Trials in St Louis — FAQ

Are there lupus clinical trials in St Louis?

Yes, there are 10 lupus clinical trials currently recruiting in St Louis, MO. Browse the studies on this page to find one that fits.

How do I join a clinical trial in St Louis?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the St Louis research site will contact you about next steps.

Are clinical trials in St Louis free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many St Louis studies also compensate for your time and travel.

What lupus treatments are being tested?

The 10 active trials in St Louis are testing new therapies including novel drugs, biologics, and treatment approaches for lupus.

Data updated July 18, 2026 from ClinicalTrials.gov