Boston, MANCT06810167Now EnrollingIRB Ready

Cystic Fibrosis Clinical Trial in Boston, MA

Access cutting-edge cystic fibrosis treatment through this clinical trial at a research site in Boston. Study-provided care at no cost to qualified participants.

Sponsored by Massachusetts General Hospital

Quick Self-Assessment

See if you qualify for this Boston location

Preparing your pre-screening questions…

Expert Care in Boston

Access cystic fibrosis specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related cystic fibrosis treatment provided free

Apply for This Boston Location

Check if you qualify for this cystic fibrosis clinical trial in Boston, MA

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Boston

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Boston site if eligible
  4. 4Begin participation

About This Cystic Fibrosis Study in Boston

Tenapanor is the newest FDA-approved drug for IBS with constipation (IBS-C). This study seeks to understand tenapanor as a treatment for cystic fibrosis-related constipation (CFrC) in CF patients. Participants will ingest one 50 mg tablet of tenapanor, twice daily, for a 4-week treatment period. They will also complete three questionnaires, the PAC-SYM, PAC-QoL, and IBS-SSS, and daily diaries to characterize GI symptom burden and spontaneous bowel movement (SBM) frequency.

Sponsor: Massachusetts General Hospital

Who Can Participate

Inclusion Criteria

Having confirmed cystic fibrosis (either by sweat chloride or genetic testing)
Meeting criteria for CFrC Must include 2 of the following, with or without abdominal pain for at least 3 months, with symptom onset at least 6-months prior:
Straining in at least 25% of defecations
Bristol Stool Scale 1-2 more than 25% of defecations (change in stool form)
Sensation of incomplete evacuation more than 25% of defecations
Sensation of anorectal obstruction/blockage more than 25% of defecations
Manual disimpaction/manipulation of pelvic floor to facilitate more than 25% of defecations
Fewer than 3 spontaneous bowel movements weekly (change in stool frequency)
Loose stools rarely present without the use of laxatives
Willingness to avoid major dietary or lifestyle changes during study.

Exclusion Criteria

Use of any antibiotic to treat infection within the 4-weeks prior to study initiation (stable azithromycin dosed 3-times weekly for lung function is to be allowed)
Inability to discontinue standing bowel regimen (including fiber, stool softener, as well as either osmotic or stimulant laxative, pro-kinetic serotonergic agents, or other therapy) 2-weeks prior to study drug initiation (with ability to use osmotic laxative therapy as rescue therapy only).
Severe CFrC as determined by study team
Prior tenapanor usage
Hospitalization within 4-weeks prior to study initiation.
DIOS within 4-weeks prior to study initiation.
Other known/suspected mechanical obstruction

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT06810167) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Cystic Fibrosis Treatment Options in Boston, MA

If you're searching for cystic fibrosis treatment options in Boston, MA, this clinical trial (NCT06810167) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced cystic fibrosis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all cystic fibrosis clinical trials near you to find additional studies recruiting in your area.

More Cystic Fibrosis Trials in Boston, MA

See all cystic fibrosis clinical trials recruiting in Boston — not just this study.

Browse Cystic Fibrosis Trials in Boston →

Browse More Trials by Condition

Cystic Fibrosis TrialsInterstitial Cystitis TrialsFibromyalgia TrialsAll Conditions →

Ready to Join in Boston?

Take the first step toward participating in this groundbreaking clinical trial

Secure · Expert Care · Boston, MA