NCT06627894 · Indiana University
Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)
(ADEPT-ICU)
What this study is about
Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD).
View original scientific description
Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors), which will test the efficacy of an internet CBT intervention called Good Days Ahead (GDA) to reduce the burden of subjective cognitive decline (SCD) in older ICU survivors with moderate to severe depressive symptoms after ICU hospitalization.
Interventions
BEHAVIORAL
Therapist-Assisted Internet Cognitive-Behavioral Therapy for Depression
Good Days Ahead (MindStreet, Inc.)
BEHAVIORAL
Active Control
Depression education, symptom monitoring, and standard depression care
Primary outcome measures
Subjective Cognitive Decline
Time frame: Measured at 6-month and 12-month follow-up.
The primary outcome will be subjective cognitive decline (SCD), measured using the Cognitive Change Index self-report version (CCI-SR).
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- 50 years of age and older
- Admitted to the intensive care for greater \> 48 hours
- Able to understand and provide informed consent
- Elevated depressive symptoms, defined as Screening PHQ-9 or PHQ-8 ≥ 10 or Screening PHQ-9 or PHQ-8 = 5-9 with the presence a core symptom of anhedonia (PHQ-9 or PHQ-8 Item 1) or depressed mood (PHQ-9 or PHQ-8 Item 2)
- Willing to participate in cognitive testing
- Access to a telephone
- Discharge to home or an independent or assisted living facility
- Response is a 1,2, or 3 on PHQ-9 or PHQ-8 item 7, answered yes to "Have you experienced a change in your memory or other aspect of thinking in the past 1 to 3 years?", or score in the 25% percentile or lower on the Montreal Cognitive Assessment (MOCA) based on normative data which account for age, gender, race, ethnicity and education.
Exclusion criteria
- Diagnosis of dementia or neurodegenerative disease (e.g. Alzheimer's disease, vascular dementia as per EHR and IQCODE, or Parkinson's disease) or on anti-dementia medications prior to ICU stay
- Diagnosis of severe mental illness (bipolar disorder, schizophrenia, schizoaffective) as per EHR and screening questions
- Persistent psychotic symptoms after ICU stay which would interfere with successful completion of intervention
- Recent or recurrent alcohol or substance use disorder as per HER and Drug Abuse Screening Test
- Life expectancy less than 1 year (e.g. terminal cancer diagnosis, discharged on hospice)
- Ischemic or hemorrhagic stroke, traumatic brain injury, or undergoing neurosurgery prior, during or after ICU stay
- Uncorrected visual or auditory impairment including legal blindness or deaf
- Status post tracheostomy and not able to communicate
- Incarcerated or on parole after ICU stay
Where
- Indianapolis, Indiana
Collaborators
National Institute on Aging (NIA)
Related conditions & keywords
Frequently asked questions
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Data: ClinicalTrials.gov · synced Dec 17, 2025 · Source of record for eligibility and locations