NCT06482814 · Mayo Clinic
Sleep Restriction and Parental History of Hypertension
What this study is about
The purpose of this study is to research the effects of partial sleep deprivation (sleep restriction) in a group of individuals whose parents have high blood pressure compared to a group of individuals whose parents have normal blood pressure.
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The purpose of this study is to research the effects of partial sleep deprivation (sleep restriction) in a group of individuals whose parents have high blood pressure compared to a group of individuals whose parents have normal blood pressure.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Healthy adults aged 18-35 years
- Absence of any significant medical or psychiatric disease (as per the investigators' judgment)
- Nonpregnant
- History of normal sleep duration (reported average sleep duration between 7-9 hours/night and no habitual napping)
- Hypertension status information available for both biological parents
- Ability to understand study procedures and to comply with them for the entire length of the study
- Ability to understand English and provide informed consent
Exclusion criteria
- Age \<18 or \>35 years
- Body mass index \<18.5 or ≥30 kg/m2
- Pregnant or lactating
- Unable to determine history of HTN in participant's biological parents or subject being adopted
- Use of tobacco, vaping, marijuana products or other drugs
- Excessive caffeine consumption (\>400 mg/day)
- Excessive alcohol consumption (\>7 drinks/week for women, \>14 drinks/week for men)
- Office SBP/DBP ≥130/80 mmHg
- Daytime ambulatory SBP/DBP ≥130/80 mmHg
- Fasting glucose ≥126 mg/dl
- Glomerular filtration rate \<60 mL/min/BSA
- History of significant medical or psychiatric disorders (as per the investigators' judgment)
- Regular use of prescription medications other than contraceptives
- Use of melatonin supplements or any other over-the-counter sleep aid
- Moderate-to-severe sleep disordered breathing (apnea/hypopnea index, AHI ≥15) or mild sleep disordered breathing (AHI 5-15) with daytime sleepiness (Epworth Sleepiness Scale \>10)
- Moderate-to-severe insomnia (Insomnia Severity Index \>14)
- Restless leg syndrome (as per the Cambridge-Hopkins questionnaire)
- Excessive daytime sleepiness (Epworth Sleepiness Scale \>15)
- Extreme chronotype (Morningness-Eveningness Questionnaire \>69 or \<31)
- Night shift work
- Ongoing participation in other research studies (as per the investigators' judgment)
- Any other medical, geographic, or social factor making study participation impractical
- Not English-speaking and/or inability to provide informed consent
Where
- Rochester, Minnesota
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Aug 1, 2025 · Source of record for eligibility and locations