NCT06986590 · Johns Hopkins University
Addressing Hypertension Care in Africa Program
(ADHINCRA)
What this study is about
The ADHINCRA Program is a bundle of multilevel evidence-based interventions that address multiple predictors of controlled hypertension, including patient-, provider-, and health system-level factors.
View original scientific description
The ADHINCRA Program is a bundle of multilevel evidence-based interventions that address multiple predictors of controlled hypertension, including patient-, provider-, and health system-level factors. The successful implementation of the ADHINCRA program will provide a rigorous and scalable model for improving hypertension control in Africa, which would ultimately reduce the risk of cardiovascular disease, stroke and kidney disease.
Interventions
BEHAVIORAL
ADHINCRA Program
The ADHINCRA Program is a nurse-led intervention that includes the use of home blood pressure monitoring, a mobile health app, lifestyle counselling, and a simplified hypertension treatment protocol to achieve blood pressure control among people diagnosed with hypertension.
Primary outcome measures
Number of participants with systolic blood pressure <140 mmHg
Time frame: Baseline and 12 months post-randomization
Blood pressure control among participants defined as systolic blood pressure \<140 mmHg
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Aged 18 -70 years.
- Diagnosis of hypertension and elevated systolic blood pressure measure (≥140 mmHg) on the most recent clinic visit without a diabetes diagnosis.
- Hypertension treatment naive or on monotherapy.
- Receives primary care at one of the participating sites.
- Willing and able to provide informed consent in English, Twi, Dagbani, Ewe, Hausa, or Yoruba.
- Owns a smartphone (Android or iOS).
Exclusion criteria
- Age \<18 years or \>70 years.
- Severely elevated BP (≥180/110mmHg).
- Diagnosis of stroke, coronary artery disease, or kidney disease.
- Diagnosis of end-stage renal disease (ESRD) treated with dialysis.
- Serious medical condition which either limits life expectancy or requires active management (e.g., cancer).
- Cognitive impairment or other conditions preventing study participation
- Pregnant or currently nursing a child
- Unwilling to provide informed consent
Where
- Baltimore, Maryland
Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jan 14, 2026 · Source of record for eligibility and locations