Boston, MANCT05593055Now EnrollingIRB Ready

Hypertension Clinical Trial in Boston, MA

Access cutting-edge hypertension treatment through this clinical trial at a research site in Boston. Study-provided care at no cost to qualified participants.

Sponsored by Brigham and Women's Hospital

Quick Self-Assessment

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Expert Care in Boston

Access hypertension specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related hypertension treatment provided free

Apply for This Boston Location

Check if you qualify for this hypertension clinical trial in Boston, MA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Boston

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Boston site if eligible
  4. 4Begin participation

About This Hypertension Study in Boston

The investigators' goal is to show that in hypertensive men and women with left ventricular hypertrophy (LVH) treatment with a mineralocorticoid receptor (MR) antagonist, versus a thiazide-like diuretic, will improve coronary microvascular function and cardiac efficiency, which will associate with improvements in LV structure and function. The investigators will achieve this through a randomized, controlled, basic experimental study involving humans (BESH).

Sponsor: Brigham and Women's Hospital

Who Can Participate

Inclusion Criteria

History of hypertension
Seated systolic BP \< 180 mmHg and diastolic \< 110 mmHg if on antihypertensives
Seated systolic BP 141-200 mmHg and/or diastolic BP 90-114 mmHg if not on antihypertensives
LVH by echocardiogram
For men: interventricular septum thickness ≥ 12mm
For women: interventricular septum thickness ≥ 11mm
We will also allow inclusion of people with treated hypothyroidism, pre-diabetes and diabetes controlled by diet, exercise, and/or metformin.

Exclusion Criteria

Use of MR antagonist (eplerenone, spironolactone, or finerenone) or amiloride (amiloride inhibits ENaC, which is a key mediator of MR's actions) within the past year
Orthostatic hypotension
Major medical illness, including uncontrolled diabetes mellitus (Hemoglobin A1c \>7.5)
LV ejection fraction \< 40%
New York Heart Association class III to IV congestive heart failure or unstable angina
A history in the prior 6 months of Q-wave myocardial infarction, stroke, transient ischemic attack, percutaneous transluminal coronary angioplasty, or coronary artery bypass graft
History of secondary hypertension
Known genetic cardiomyopathy
Renal disease (seum creatinine \>1.5 mg/dL for men and \>1.3 mg/dL for women)
Hepatic disease
Bronchospastic lung disease
Alcohol or substance abuse
Hormone replacement therapy
Abnormal values for electrolytes, liver enzymes or TSH
Pregnancy or lactation
All individuals \<18 and \>75 years will be excluded due to safety concerns of administering an angiotensin-II infusion in these patient groups.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT05593055) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Hypertension Treatment Options in Boston, MA

If you're searching for hypertension treatment options in Boston, MA, this clinical trial (NCT05593055) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced hypertension specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all hypertension clinical trials near you to find additional studies recruiting in your area.

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