Philadelphia, PANCT07845604Now EnrollingIRB Ready

Major Depressive Disorder (MDD) Clinical Trial in Philadelphia, PA

Access cutting-edge major depressive disorder (mdd) treatment through this phase 2 clinical trial at a research site in Philadelphia. Study-provided care at no cost to qualified participants.

Sponsored by Daniel Moriarity

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Expert Care in Philadelphia

Access major depressive disorder (mdd) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related major depressive disorder (mdd) treatment provided free

Apply for This Philadelphia Location

Check if you qualify for this major depressive disorder (mdd) clinical trial in Philadelphia, PA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Philadelphia

    Convenient for PA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Philadelphia site if eligible
  4. 4Begin participation

About This Major Depressive Disorder (MDD) Study in Philadelphia

The goal of this clinical trial is to learn if the anti-inflammatory medication adalimumab improves depressive symptoms in adults with Major Depressive Disorder (MDD) who are already taking the anti-depressant medication Lexapro (escitalopram). The main questions it aims to answer are: 1. Does adalimumab improve the symptoms of some patients with MDD who are already taking an anti-depressant? 2. What characteristics predict for whom adalimumab has anti-depressant properties. Researchers will compare adalimumab to a placebo (a look-alike substance that contains no drug) to see if adalimumab works to improve depressive symptoms as an add-on drug to the anti-depressant Lexapro (escitalopram). For these primary aims the participants will: 1. Visit the clinic once every 2 weeks for a checkups and injection of adalimumab or placebo from the study psychiatrist (Day 1, 15, 29, and 43 for injections) 2. Complete short (\<5 min) daily surveys for the 57 day duration of the study.

Sponsor: Daniel Moriarity

Who Can Participate

Inclusion Criteria

Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for the duration of the study
Male or female, aged 18+ years
Meet DSM-5 criteria for Major Depressive Disorder
baseline serum TNF-alpha (average of two samples in the same week) greater than 1.5 pg/mL
Taking a steady dose of Lexapro (escitalopram) for at least 4 weeks
Ability to take oral medication and physician-administered subcutaneous injection and be willing to adhere to the study protocol
For females of reproductive potential: use of highly effective contraception for at least 1 month
Access to a phone or computer with a camera

Exclusion Criteria

Pregnant or breastfeeding
Active, chronic or recurrent infection
Known malignancy
Current use of immune modulating medications
Immunocompromised, current autoimmune condition or history of severe immune condition (e.g., history of cancer, HIV/AIDS)
History of, or positive test for, Hepatitis B surface antigen or core antibody positivity or tuberculosis (TB)
Congestive heart failure
History of demyelinating disease (multiple sclerosis (MS), optic neuritis, Guillain-Barre syndrome)
History of seizure disorder
Symptomatic hyponatremia
Monoamine oxidase inhibitors (MAOI) use within 14 days
Recent use of Rituxan (rituximab)
Concomitant use of:
Immunosuppressants
Kineret (anakinra)
Orencia (abatacept)
Remicade (infliximab)
Enbrel (etanercept)
Cimzia (certolizumab pegol)
Simponi (golimumab)
Imuran (azathioprine)
Purinethol (6-mercaptopurine)
IV methylene blue
Antiplatelet agents
Strong anticoagulants (e.g. warfarin, large doses of NSAIDs)
Other SSRIs, SNRIs, tryptophan
Clinically relevant substance use disorder
Known allergic reactions to components of adalimumab and/or escitalopram
Treatment with another investigational drug or other intervention while participating in the study

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Philadelphia?

Yes, this clinical trial (NCT07845604) has an active research site in Philadelphia, PA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Major Depressive Disorder (MDD) Treatment Options in Philadelphia, PA

If you're searching for major depressive disorder (mdd) treatment options in Philadelphia, PA, this clinical trial (NCT07845604) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Philadelphia research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced major depressive disorder (mdd) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all major depressive disorder (mdd) clinical trials near you to find additional studies recruiting in your area.

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