Is NCT07104799 recruiting in Boston, MA?

Yes, NCT07104799 is currently recruiting participants at its Boston, MA location. This myelofibrosis clinical trial is actively enrolling qualified participants.

How do I join the myelofibrosis clinical trial in Boston?

To join this clinical trial in Boston, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Boston clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Myelofibrosis Clinical Trial in Boston, MA

Who Can Participate

Inclusion Criteria

Participants must have pathologically confirmed primary myelofibrosis (PMF) according to WHO criteria or secondary myelofibrosis as defined by the IWG-MRT criteria.

Intermediate-2/ high-risk disease as per Dynamic IPSS (DIPSS) Plus criteria OR

Intermediate-1 risk disease with at least one of the following unfavorable features known to impact the survival adversely

Red cell transfusion dependency

Unfavorable Karyotype

Platelet count ≤100 x 10\^9/L

Presence of a high risk molecular marker associated with worsened overall survival (ASXL1, EZH2, IDH1/2, SRSF2, U2AF1, p53)

Participants do not have to be receiving treatment with JAK inhibitors for MF at the time of enrollment. If participants are receiving JAK inhibitor therapy with agents other momelotinib, participants must agree to be switched to momelotinib to begin Cycle 1 Day 1 on Day -7 from HCT (at the initiation of conditioning).

Age \>18 years

Participants must be designated to undergo allogeneic HCT with:

reduced intensity conditioning regimen, and

peripheral blood stem cells as a graft source

Participants who will undergo HCT from the following donor types are eligible:

6/6 (HLA-A, B, DR) fully matched related donor or

8/8 (HLA-A, B, DR, C) fully matched unrelated donor. Matching in the unrelated setting must be at the allele level

ECOG performance status ≤2 (Karnofsky ≥60%)

The effects of momelotinib on the developing human fetus are unknown. Female patients of childbearing potential must have a negative pregnancy test, as measured by serum or urine testing. Women of childbearing potential: must agree to use highly effective contraception prior to the initial dose/start of the first treatment, during the study, and for at least 1 week after the last dose of momelotinib. Male participants with women of child bearing potential partners must agree to use one of the forms of medically acceptable birth control at start of the first treatment, during the study, and for at least 6 months after the last dose. See

Exclusion Criteria

for effective contraception and birth control. \- Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria:

Known intolerance or hypersensitivity to any JAK inhibitor, including ruxolitinib, fedratinib, pacritinib, momelotinib or any other JAK inhibitor, its metabolites or formulation excipients.

Has had any major surgery within 28 days prior to randomization

Has received treatment with an investigational agent within 4 weeks of the first dose of study intervention

Has received immunosuppressive agents within 28 days

Prior allogeneic transplant for any hematopoietic disorder

Had accelerated phase or leukemic transformation (≥10% blasts in bone marrow any time prior to HCT)

Has an active, uncontrolled infection

Has cirrhosis or current unstable liver or biliary disease per investigator assessment defined by the presence of ascites, encephalopathy, coagulopathy, hypoalbuminemia, esophageal/gastric varices, or persistent jaundice.

Known diagnosis of active hepatitis B or hepatitis C.

History of another malignancy(ies), unless:

the participant has been disease-free for at least 2 years and is deemed by the investigator to be at low risk of recurrence of that malignancy, or

the cancer has been deemed indolent with no progression over the last 2 years, and deemed by the investigator to be at low risk for further progression during the course of study and follow-up

the only prior malignancy was cervical cancer in situ and/or basal cell or squamous cell carcinoma of the skin

Participants without normal organ function defined as follows:

AST (SGOT), ALT (SGPT) and Alkaline Phosphatase \>3 × institutional Upper Limit of Normal (ULN)

Total bilirubin \>1.5 mg/dL, with the exception of participants with Gilbert's Syndrome provided direct bilirubin is ≤1.5x ULN and participant otherwise meets entry criteria.

Calculated creatinine clearance ≤60 mL/min (Cockcroft-Gault formula)

Have current or a history of congestive heart failure New York Heart Association (NYHA) class 3 or 4, or any history of documented diastolic or systolic dysfunction (LVEF \< 40%, as measured by MUGA scan or echocardiogram) or clinically significant arrhythmia not controlled by standard of care therapy.

Not able to take oral medication or having any clinically significant gastrointestinal abnormalities that may alter absorption, e.g., malabsorption syndrome or major resection of the stomach and/or bowels.

Grade 2 or greater peripheral neuropathy

Pregnant or lactating women, or women planning to become pregnant or initiating breastfeeding.

To exclude women of childbearing potential: who are unwilling or unable to practice highly effective contraception prior to the initial dose/start of the first treatment, during the study, and for at least 1 week after the last dose. Highly effective contraceptive measures include:

stable use of combined (estrogen and progestogen containing) hormonal contraception (oral, intravaginal, transdermal) or progestogen-only hormonal contraception (oral, injectable, implantable) associated with inhibition of ovulation initiated 2 or more menstrual cycles prior to screening;

intrauterine device (IUD); intrauterine hormone-releasing system (IUS);

sexual abstinence;

intercourse with vasectomized partner (provided that the male vasectomized partner is the sole sexual partner of the WOCBP study participant and that the vasectomized partner has obtained medical assessment of surgical success for the procedure).

To exclude sexually active male participants with WOCBP partners who are unwilling to use the one of the following forms of medically acceptable birth control at start of the first treatment, during the study, and for at least 6 months after the last dose:

vasectomy with medical assessment of surgical success OR consistent use of a condom.

male participants must also agree not to donate sperm while receiving study drug and for at least 6 months after the last dose.

Patients receiving strong CYP 3A4 inducers during study period

Patients with major ABO mismatch donors only

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT07104799) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Myelofibrosis Treatment Options in Boston, MA

If you're searching for myelofibrosis treatment options in Boston, MA, this clinical trial (NCT07104799) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced myelofibrosis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all myelofibrosis clinical trials near you to find additional studies recruiting in your area.

Myelofibrosis Clinical Trial in Boston, MA

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About This Myelofibrosis Study in Boston