Hershey, PANCT05937594Now EnrollingIRB Ready

Neonatal Opioid Withdrawal Syndrome Clinical Trial in Hershey, PA

Access cutting-edge neonatal opioid withdrawal syndrome treatment through this clinical trial at a research site in Hershey. Study-provided care at no cost to qualified participants.

Sponsored by Milton S. Hershey Medical Center

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Expert Care in Hershey

Access neonatal opioid withdrawal syndrome specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related neonatal opioid withdrawal syndrome treatment provided free

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Check if you qualify for this neonatal opioid withdrawal syndrome clinical trial in Hershey, PA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Hershey

    Convenient for PA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Hershey site if eligible
  4. 4Begin participation

About This Neonatal Opioid Withdrawal Syndrome Study in Hershey

Infants with neonatal abstinence syndrome (NAS) experience prolonged hospital stays and poor neurodevelopmental outcomes, in-part because of the lack of accurate, individualized, biologic assessments available to manage this increasingly common medical condition. The proposed study will define the molecular mechanisms that regulate the response to opioid withdrawal in the developing brain by focusing on three candidate microRNAs (let-7a, miR-146a, miR-192) that have been shown to respond to opioid exposure in animal models and adults, and are impacted in both my preliminary study of infants with NAS, and my human neural progenitor cell (NPC) design of opioid withdrawal. By determining the mechanism through which microRNAs impact NPC differentiation in opioid withdrawal, and determining whether exosomal salivary microRNA levels predict treatment dose and neurodevelopmental outcomes in infants with NAS, this study will enhance our knowledge of NAS-related biology and identify potential biomarkers that could improve medical care for this important medical condition.

Sponsor: Milton S. Hershey Medical Center

Who Can Participate

Inclusion Criteria

Newborns ≥35weeks gestation with chronic in-utero opioid exposure (\>1month of gestation exposure). Maternal exposure will be determined by evaluating the medical records for maternal medication use, maternal urine toxicology and neonatal meconium toxicology results per standard clinical care
Neonates born at Penn State Hershey Medical Center or transferred at \<48 hours after birth
Mothers with chronic in-utero opioid use during pregnancy ( ≥1month of gestation)

Exclusion Criteria

\<35 week gestation
Infant required mechanical ventilation or non-invasive mechanical support
Infant exposure to magnesium sulfate
Opioid-exposed neonates who are actively receiving dextrose infusion for persistent neonatal hypoglycemia at the time of enrollment (\<48hours after birth).
Infant with major congenital anomalies
Parent or guardian unable to provide consent
Mothers and neonates without history of opioid exposure/dependence

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Hershey?

Yes, this clinical trial (NCT05937594) has an active research site in Hershey, PA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Neonatal Opioid Withdrawal Syndrome Treatment Options in Hershey, PA

If you're searching for neonatal opioid withdrawal syndrome treatment options in Hershey, PA, this clinical trial (NCT05937594) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Hershey research site is actively enrolling participants for this clinical trial. You'll receive care from experienced neonatal opioid withdrawal syndrome specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all neonatal opioid withdrawal syndrome clinical trials near you to find additional studies recruiting in your area.

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