St Louis, MONCT04629547Now EnrollingIRB Ready

Sleep Clinical Trial in St Louis, MO

Access cutting-edge sleep treatment through this phase 2 clinical trial at a research site in St Louis. Study-provided care at no cost to qualified participants.

Sponsored by Washington University School of Medicine

Quick Self-Assessment

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Expert Care in St Louis

Access sleep specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related sleep treatment provided free

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Check if you qualify for this sleep clinical trial in St Louis, MO

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to St Louis

    Convenient for MO residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit St Louis site if eligible
  4. 4Begin participation

About This Sleep Study in St Louis

The purpose of this study is to determine if treatment with the sleep aid suvorexant can decrease the rate of amyloid-β (Aβ) accumulation in the brain.

Sponsor: Washington University School of Medicine

Who Can Participate

Inclusion Criteria

Male or female.
Any race or ethnicity.
Participants must be age ≥65 years and able to sign informed consent.
Global Clinical Dementia Rating (CDR) 0.
Willing and able to undergo study procedures.

Exclusion Criteria

History of reported symptoms suggestive of restless legs syndrome, narcolepsy or other central disorder of hypersomnolence, or parasomnia
STOP-Bang score \>6 for participants without PAP
Untreated OSA with AHI ≥15 on home sleep test
Treated sleep apnea with PAP non-compliance
PAP compliance is defined as \>= 4 hours per night \>70% of the nights
Plasma A-beta and tau test with a plasma p-tau 217% ≤ 1.19
Chronic kidney disease defined as patients with markers of kidney damage or eGFR of \< 45 ml/min/1.73m2.
Hepatic impairment defined as AST and/or ALT \> 2x upper limit of normal (normal limits AST: 11-47 IU/L, ALT: 6-53 IU/L).
History of substance abuse or alcohol abuse in the proceeding 6 months.
Regular alcohol consumption 3 or more days a week over the last 6 months. Regular alcohol consumption is defined as having more than 2 alcoholic beverages within 3 hours of bedtime. Participants that agree to reduce alcohol consumption during the study may not be excluded.
History of presence of any clinically significant medical condition, behavioral or psychiatric disorder, or surgical history based on medical record or participant report that could affect the safety of the participant or interfere with study assessments or in the judgement of the Principal-Investigator (PI) if participant is not a good candidate.
Has any medical condition that, in the PI's opinion, could increase risk to the participant, limit the participant's ability to tolerate the research procedures, or interfere with the collection/analysis of the data. Potential medical conditions that will be exclusionary at the PI's discretion:
Cardiovascular disease requiring medication except for controlled hypertension.
Pulmonary disease.
Type I diabetes.
Neurologic or psychiatric disorder requiring medication.
Tobacco use.
Use of sedating medications.
Use of medications that interact with suvorexant (if cannot be discontinued)
Abnormal safety labs
History of current suicidal ideations.
Currently pregnant or breast-feeding.
In the opinion of the PI, the participant should be excluded due to an abnormal physical examination.
Must not have participated in any clinical trial involving a study drug or device within the 30-days prior to study enrollment.
Must not participate in another drug or device study prior to the end of this study participation. Exclusion criteria for optional lumbar punctures -• Contraindication to lumbar puncture (anticoagulants; bleeding disorder; allergy to lidocaine or disinfectant; prior central nervous system or lower back surgery).

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in St Louis?

Yes, this clinical trial (NCT04629547) has an active research site in St Louis, MO that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Sleep Treatment Options in St Louis, MO

If you're searching for sleep treatment options in St Louis, MO, this clinical trial (NCT04629547) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our St Louis research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced sleep specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all sleep clinical trials near you to find additional studies recruiting in your area.

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