A Long-Term Study of ALKS 2680 in Subjects With Narcolepsy and Idiopathic Hypersomnia
The purpose of this study is to continue to measure the safety, tolerability, and durability of treatment effect in subjects with Narcolepsy Type 1 (NT1), Narcolepsy Type 2 (NT2), or Idiopathic Hypers...
A Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia
Narcolepsy Type 1 (NT1), Narcolepsy Type 2 (NT2), and Idiopathic Hypersomnia (IH) are rare conditions that make people feel very sleepy during the day (often referred to as excessive daytime sleepines...
A Study of TAK-360 in Adults With Narcolepsy Without Cataplexy (NT2)
Narcolepsy without cataplexy or Narcolepsy Type 2 (NT2) is a lifelong condition that makes people very sleepy during the day, regardless of how much sleep they get at night. People with NT2 may fall a...
Top Cities for Narcolepsy Clinical Trials
Narcolepsy clinical trials are recruiting across 22 cities. Here are the cities with the most active studies:
About Narcolepsy
Narcolepsy is a chronic neurological disorder that affects the brain's ability to control sleep-wake cycles, causing excessive daytime sleepiness and sudden loss of muscle tone (cataplexy). It is caused by a deficiency of the brain chemical hypocretin. Treatment includes stimulant medications and sodium oxybate.
Clinical trials are advancing new treatments for narcolepsy. Currently, 3 studies are recruiting a combined 392 participants across the United States. Research is being conducted by 3 organizations including Alkermes, Inc., Centessa Pharmaceuticals (UK) Limited, Takeda.
2026 Narcolepsy Research Landscape
As of March 2026, the narcolepsy clinical trial landscape includes 3 actively recruiting studies across 22 cities in the United States. These studies are collectively seeking 392 participants, with an average enrollment target of 131 per study.
Research is being led by 3 different organizations, including Alkermes, Inc., Centessa Pharmaceuticals (UK) Limited, Takeda.
Geographically, narcolepsy trials are most concentrated in Brandon, Florida (3 trials); Miami, Florida (3 trials); Colorado Springs, Colorado (2 trials); Winter Park, Florida (2 trials); Santa Ana, California (2 trials) and 7 other cities.
Featured Narcolepsy Studies
Highlighted recruiting studies for narcolepsy, selected by enrollment size and research scope.
A Long-Term Study of ALKS 2680 in Subjects With Narcolepsy and Idiopathic Hypersomnia
The purpose of this study is to continue to measure the safety, tolerability, and durability of treatment effect in subjects with Narcolepsy Type 1 (NT1), Narcolepsy Type 2 (NT2), or Idiopathic Hypersomnia (IH) when taking ALKS 2680 tablets.
A Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia
Narcolepsy Type 1 (NT1), Narcolepsy Type 2 (NT2), and Idiopathic Hypersomnia (IH) are rare conditions that make people feel very sleepy during the day (often referred to as excessive daytime sleepiness \[EDS\]). People living with these conditions might find it hard to stay alert and pay attention when they are at school, working, driving, or performing other daily activities. While all condition...
A Study of TAK-360 in Adults With Narcolepsy Without Cataplexy (NT2)
Narcolepsy without cataplexy or Narcolepsy Type 2 (NT2) is a lifelong condition that makes people very sleepy during the day, regardless of how much sleep they get at night. People with NT2 may fall asleep suddenly, have trouble staying awake during the day, or may not be able to sleep well at night. They may have difficulty thinking clearly, paying attention, or remembering things, during the day...
Frequently Asked Questions About Narcolepsy Clinical Trials
Are there narcolepsy clinical trials near me?
Yes, there are 3 narcolepsy clinical trials currently recruiting across 22+ cities in the United States, including Brandon, Florida; Miami, Florida; Colorado Springs, Colorado. Browse the studies above to find one at a location convenient for you.
How do I join a narcolepsy clinical trial?
To join a narcolepsy clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are narcolepsy clinical trials free?
Yes, participation in narcolepsy clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of narcolepsy treatments are being studied?
Current narcolepsy clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 3 research organizations.
Is it safe to participate in narcolepsy clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 1, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 1, 2026 · Data from ClinicalTrials.gov