Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Narcolepsy Clinical Trials
Narcolepsy clinical trials are recruiting across 70 cities. Here are the cities with the most active studies:
Narcolepsy Trial Phases
10 research organizations are sponsoring narcolepsy trials.
About Narcolepsy
Narcolepsy is a chronic neurological disorder that affects the brain's ability to control sleep-wake cycles, causing excessive daytime sleepiness and sudden loss of muscle tone (cataplexy). It is caused by a deficiency of the brain chemical hypocretin. Treatment includes stimulant medications and sodium oxybate.
Clinical trials are advancing new treatments for narcolepsy. Currently, 20 studies are recruiting a combined 5,183 participants across the United States. Research is being conducted by 10 organizations including Axsome Therapeutics, Inc., Takeda, Harmony Biosciences Management, Inc. and 7 others.
2026 Narcolepsy Research Landscape
As of September 2026, the narcolepsy clinical trial landscape includes 20 actively recruiting studies across 70 cities in the United States. These studies are collectively seeking 5,183 participants, with an average enrollment target of 259 per study.
The research spans multiple phases of development: 10 studies are in PHASE3, 9 studies are in PHASE2, 2 studies are in PHASE1, 1 study is in NA. The presence of Phase 3 trials indicates that some narcolepsy treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 10 different organizations, including Axsome Therapeutics, Inc., Takeda, Harmony Biosciences Management, Inc., Alkermes, Inc., Centessa Pharmaceuticals (UK) Limited, and 5 others.
Geographically, narcolepsy trials are most concentrated in Miami, Florida (11 trials); Brandon, Florida (8 trials); Los Angeles, California (6 trials); Atlanta, Georgia (6 trials); Cincinnati, Ohio (6 trials) and 7 other cities.
Featured Narcolepsy Studies
Highlighted recruiting studies for narcolepsy, selected by enrollment size and research scope.
SUNOSI® (Solriamfetol) Pregnancy Registry
The SUNOSI (solriamfetol) Pregnancy Registry is a prospective, multi-country, observational study to evaluate the safety of solriamfetol exposure during pregnancy in women with a diagnosis of narcolepsy or obstructive sleep apnea (OSA).
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
CLARITY (Clinical Assessment of Response in the Treatment of Depression with Daytime Sleepiness Using Solriamfetol) is a Phase 3, double-blind, placebo-controlled, multicenter randomized withdrawal trial in patients with major depressive disorder (MDD) with excessive daytime sleepiness (EDS) symptoms consisting of an open-label solriamfetol treatment period and a randomized, double-blind treatment...
A Study of TAK-360 in People With Narcolepsy or Idiopathic Hypersomnia
Central hypersomnia conditions are a group of sleeping disorders where the brain has trouble keeping a person awake during the day (called excessive daytime sleepiness or EDS). These conditions usually include narcolepsy (type 1 and 2) and idiopathic hypersomnia (IH). Narcolepsy type 1 (NT1) includes sudden muscle weakness while you stay awake, called cataplexy, often triggered by strong emotions....
Frequently Asked Questions About Narcolepsy Clinical Trials
Are there narcolepsy clinical trials near me?
Yes, there are 20 narcolepsy clinical trials currently recruiting across 70+ cities in the United States, including Miami, Florida; Brandon, Florida; Los Angeles, California. Browse the studies above to find one at a location convenient for you.
How do I join a narcolepsy clinical trial?
To join a narcolepsy clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are narcolepsy clinical trials free?
Yes, participation in narcolepsy clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of narcolepsy treatments are being studied?
Current narcolepsy clinical trials are testing a range of approaches across PHASE3 (10 studies), PHASE2 (9 studies), PHASE1 (2 studies), NA (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 10 research organizations.
Is it safe to participate in narcolepsy clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated September 1, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated September 1, 2026 · Data from ClinicalTrials.gov