San Diego, CANCT07217223Now EnrollingIRB Ready

Treatment Resistant Depression (TRD) Clinical Trial in San Diego, CA

Access cutting-edge treatment resistant depression (trd) treatment through this clinical trial at a research site in San Diego. Study-provided care at no cost to qualified participants.

Sponsored by University of California, San Diego

Quick Self-Assessment

See if you qualify for this San Diego location

Preparing your pre-screening questions…

Expert Care in San Diego

Access treatment resistant depression (trd) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related treatment resistant depression (trd) treatment provided free

Apply for This San Diego Location

Check if you qualify for this treatment resistant depression (trd) clinical trial in San Diego, CA

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to San Diego

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit San Diego site if eligible
  4. 4Begin participation

About This Treatment Resistant Depression (TRD) Study in San Diego

The investigators propose a single-arm, open-label study to evaluate the effectiveness, safety, tolerability and feasibility of at-home transcranial direct current stimulation (tDCS) as a treatment for depression, particularly in cases where patients have not responded well to traditional therapies. Treatment will be delivered over a 2-week period with daily weekday treatments i.e., five tDCS sessions, each lasting 20 minutes, spaced by approximately 20-minute inter-session intervals, for a total of three hours a day. Participants will self-administer treatment at home under direct remote supervision. Pre- and post- treatment neurophysiological biomarkers sessions will also be carried out. The study aims to examine changes in mood, brain activity, and related clinical outcomes before, during, and after treatment, with the goal to provide more information that can be used for future studies. PLEASE NOTE: THERE WILL BE 4 APPOINTMENTS THAT MUST OCCUR IN PERSON IN SAN DIEGO, CA.

Sponsor: University of California, San Diego

Who Can Participate

Inclusion Criteria

People between the ages of 18 and 85 at the time of screening.
Currently diagnosed with Major Depressive Disorder (MDD) as measured by the MINI and a MADRS score of ≥ 20.
Safe for TMS as measures by the TMS Adult Safety Screening (TASS).
Medical records confirming a history of failing to achieve clinical response to an adequate antidepressant trial as defined an Antidepressant Treatment History Form (ATHF) score ≥ 3 or ) or shown intolerance to at least two inadequate trials (score 1 or 2), without psychiatric illness due to a general medical condition.
Stable internet connection and a device compatible with Microsoft Teams.

Exclusion Criteria

History of psychotic or bipolar disorder or depression with psychotic features;
Significant borderline personality disorder;
Significant comorbid obsessive-compulsive or post-traumatic stress:
Current moderate or severe substance use disorder or demonstrating signs of acute substance withdrawal;
Clinically significant suicidality disorder;
Chronic depression (defined as of over 5 years duration);
Pregnancy or lactation, lack of adequate birth control in women of childbearing age;
History of significant neurologic disease, including dementia, Parkinson's or Huntington's disease, brain tumor, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma with persistent symptoms;
Unstable medical illness;
Contraindication to receiving tDCS (e.g., ferromagnetic implant, history of seizure, known brain lesion);
History of TMS (greater than 15 sessions) without a clinically meaningful response.; History of ketamine (greater than 4 sessions) without a clinically meaningful response;
Require a benzodiazepine with a dose \> lorazepam 2 mg/day;
dermatological conditions contraindicating tDCS;
Non-correctable sensory impairments;
Inability to consent or participate as an outpatient

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in San Diego?

Yes, this clinical trial (NCT07217223) has an active research site in San Diego, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Treatment Resistant Depression (TRD) Treatment Options in San Diego, CA

If you're searching for treatment resistant depression (trd) treatment options in San Diego, CA, this clinical trial (NCT07217223) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our San Diego research site is actively enrolling participants for this clinical trial. You'll receive care from experienced treatment resistant depression (trd) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all treatment resistant depression (trd) clinical trials near you to find additional studies recruiting in your area.

More Depression Trials in San Diego, CA

See all depression clinical trials recruiting in San Diego — not just this study.

Browse Depression Trials in San Diego →

Browse More Trials by Condition

Depression TrialsMajor Depressive Disorder TrialsMyalgic Encephalomyelitis TrialsAll Conditions →

Ready to Join in San Diego?

Take the first step toward participating in this groundbreaking clinical trial

Secure · Expert Care · San Diego, CA