Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Fragile X Syndrome Clinical Trials
Fragile X Syndrome clinical trials are recruiting across 11 cities. Here are the cities with the most active studies:
Fragile X Syndrome Trial Phases
2 research organizations are sponsoring fragile x syndrome trials.
About Fragile X Syndrome
Fragile X syndrome is the most common inherited cause of intellectual disability and autism, caused by a mutation in the FMR1 gene on the X chromosome. It affects approximately 1 in 4,000 males and 1 in 8,000 females. Treatment is supportive, with clinical trials exploring targeted therapies.
Clinical trials are advancing new treatments for fragile x syndrome. Currently, 4 studies are recruiting a combined 360 participants across the United States. Research is being conducted by 2 organizations including Children's Hospital Medical Center, Cincinnati, Mirum Pharmaceuticals, Inc..
2026 Fragile X Syndrome Research Landscape
As of July 2026, the fragile x syndrome clinical trial landscape includes 4 actively recruiting studies across 11 cities in the United States. These studies are collectively seeking 360 participants, with an average enrollment target of 90 per study.
The research spans multiple phases of development: 3 studies are in NA, 1 study is in PHASE2.
Research is being led by 2 different organizations, including Children's Hospital Medical Center, Cincinnati, Mirum Pharmaceuticals, Inc..
Geographically, fragile x syndrome trials are most concentrated in Cincinnati, Ohio (3 trials); Phoenix, Arizona (1 trial); Irvine, California (1 trial); Orange, California (1 trial); Sacramento, California (1 trial) and 6 other cities.
Featured Fragile X Syndrome Studies
Highlighted recruiting studies for fragile x syndrome, selected by enrollment size and research scope.
Alpha Auditory Entrainment for Cognitive Enhancement and Sensory Hypersensitivity in Youth With Developmental Disorders
Fragile X Syndrome (FXS) is a complex neurodevelopmental disorder caused by a mutation on the X chromosome. Scientists have investigated FXS extensively in both humans and animals. Thus far, phenotypic rescue in animal models has not resulted in treatment breakthroughs in humans, though some important discoveries have been made. Research has shown that individuals with FXS process sounds different...
Tracking Early Emergence of Sound Perception Impairments in FXS With Multimodal fNIRS/EEG-Preschool Age
Individuals with Fragile X Syndrome show differences in how they understand and learn language from infancy. They frequently have lifelong delays in speech and language as well. In addition, they experience other auditory symptoms, including being very sensitive to certain sounds as well as being more sensitive than others to loud sounds. The underlying brain activity for sound perception and spee...
Study of MRM-3379 in Male Participants With Fragile X Syndrome (BLOOM)
This study is a multicenter, double-blind, randomized, placebo-controlled study to assess the safety and tolerability of 3 doses of MRM-3379 in male participants with Fragile X Syndrome ages 16 to 45 (inclusive). In addition, a parallel cohort of participants ages 13 to \<16 will receive open-label MRM-3379. All participants will participate for 12 weeks of treatment. The study is also intended as...
Frequently Asked Questions About Fragile X Syndrome Clinical Trials
Are there fragile x syndrome clinical trials near me?
Yes, there are 4 fragile x syndrome clinical trials currently recruiting across 11+ cities in the United States, including Cincinnati, Ohio; Phoenix, Arizona; Irvine, California. Browse the studies above to find one at a location convenient for you.
How do I join a fragile x syndrome clinical trial?
To join a fragile x syndrome clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are fragile x syndrome clinical trials free?
Yes, participation in fragile x syndrome clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of fragile x syndrome treatments are being studied?
Current fragile x syndrome clinical trials are testing a range of approaches across NA (3 studies), PHASE2 (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 2 research organizations.
Is it safe to participate in fragile x syndrome clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 15, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 15, 2026 · Data from ClinicalTrials.gov