Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Restless Legs Syndrome Clinical Trials
Restless Legs Syndrome clinical trials are recruiting across 6 cities. Here are the cities with the most active studies:
Restless Legs Syndrome Trial Phases
6 research organizations are sponsoring restless legs syndrome trials.
About Restless Legs Syndrome
Restless legs syndrome (RLS) is a neurological condition characterized by an uncontrollable urge to move the legs, usually accompanied by uncomfortable sensations. Symptoms typically worsen at night and can severely disrupt sleep. Treatment includes iron supplementation, dopaminergic agents, and lifestyle modifications.
Clinical trials are advancing new treatments for restless legs syndrome. Currently, 6 studies are recruiting a combined 321 participants across the United States. Research is being conducted by 6 organizations including University of Texas at Austin, HBC Immunology Inc, University of Alabama at Birmingham and 3 others.
2026 Restless Legs Syndrome Research Landscape
As of July 2026, the restless legs syndrome clinical trial landscape includes 6 actively recruiting studies across 6 cities in the United States. These studies are collectively seeking 321 participants, with an average enrollment target of 54 per study.
The research spans multiple phases of development: 3 studies are in NA, 1 study is in PHASE4.
Research is being led by 6 different organizations, including University of Texas at Austin, HBC Immunology Inc, University of Alabama at Birmingham, Stanford University, Noctrix Health, Inc., and 1 others.
Geographically, restless legs syndrome trials are most concentrated in Austin, Texas (1 trial); San Francisco, California (1 trial); Birmingham, Alabama (1 trial); Stanford, California (1 trial); Pleasanton, California (1 trial) and 1 other cities.
Featured Restless Legs Syndrome Studies
Highlighted recruiting studies for restless legs syndrome, selected by enrollment size and research scope.
Nighttime Agitation and Restless Legs Syndrome in People With Alzheimer's Disease
Nighttime agitation in persons with Alzheimer's disease causes patient suffering, distresses caregivers, and often results in prescriptions for harmful antipsychotics. Effective treatments are lacking because of limited knowledge of the etiology of nighttime agitation. The investigators propose a clinical trial to better elucidate whether a sleep disorder, restless legs syndrome, may be a mechanis...
Observe Change in Nasal Swab DRD2 Gene Expression in Restless Legs Syndrome (RLS) Patients on Prolonged Dopamine Agonist Treatment
The study aims to observe changes in dopaminergic genes expression in peripheral tissue upon prolonged dopamine agonist treatment on patients with Restless Legs Syndrome (RLS). Similar studies in Parkinson's disease have shown changes in alpha-synuclein expression, which might offer insights into the dopaminergic gene regulation seen in RLS. The dopamine agonist drugs to be included in this study ...
The Effect of Spinal Cord Stimulators on Restless Leg Syndrome
This study aims to evaluate neurophysiological responses and symptom changes in individuals with Restless Legs Syndrome (RLS) and/or chronic pain. Participants will undergo standard clinical assessments including EEG, EMG, h-reflex, SSEP, ERP, and TMS under varying SCS conditions.The study involves 4 arms. Arm 1 are individuals diagnosed with RLS and Healthy Controls. Arm 2 are individuals diagnos...
Frequently Asked Questions About Restless Legs Syndrome Clinical Trials
Are there restless legs syndrome clinical trials near me?
Yes, there are 6 restless legs syndrome clinical trials currently recruiting across 6+ cities in the United States, including Austin, Texas; San Francisco, California; Birmingham, Alabama. Browse the studies above to find one at a location convenient for you.
How do I join a restless legs syndrome clinical trial?
To join a restless legs syndrome clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are restless legs syndrome clinical trials free?
Yes, participation in restless legs syndrome clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of restless legs syndrome treatments are being studied?
Current restless legs syndrome clinical trials are testing a range of approaches across NA (3 studies), PHASE4 (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 6 research organizations.
Is it safe to participate in restless legs syndrome clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 15, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 15, 2026 · Data from ClinicalTrials.gov