17 Atrial Fibrillation Clinical Trials in Chicago, IL (2026)

Q: How do I join a clinical trial in Chicago?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you.

Recruiting Atrial Fibrillation Studies in Chicago

NCT05978466Recruiting

MANAGE-AF Registry -MANAGEment of Atrial Fibrillation Outcomes Registry (MANAGE-AF)

The purpose of this research is to learn more about the normal care of patients with a new or pre-existing diagnosis of atrial fibrillation (AF). These abnormal and irregular heartbeats place patients...

Chicago, IL1,000 participantsCorVita Science Foundation

View Study Details

NCT06511505Recruiting

NOrthwestern Tempus AI-enaBLed Electrocardiography (NOTABLE) Trial

The goal of this clinical trial is to determine if a machine learning/artificial intelligence (AI)-based electrocardiogram (ECG) algorithm (rECHOmmend and ECG-AF) can identify undiagnosed cardiovascul...

Chicago, ILNA1,000 participantsNorthwestern University

View Study Details

NCT06989775Recruiting

BoxX-NoAF Clinical Trial

Post Operative Atrial Fibrillation (POAF) is the most common complication of cardiac surgery. POAF incidence can exceed 50% depending on the patient baseline characteristics and surgery type. Patients...

Chicago, ILNA960 participantsAtriCure, Inc.

View Study Details

NCT06876649Recruiting

A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib

The master protocol study J2N-MC-JZNY provides a framework to enable the evaluation of the long-term safety and efficacy of pirtobrutinib after completion of clinical studies evaluating pirtobrutinib....

Chicago, ILPHASE4787 participantsEli Lilly and Company

View Study Details

NCT06578104Recruiting

PULSED AF Post-Approval Study

PULSED AF PAS is a prospective, global, multi-center, non-randomized, observational trial. Subjects will be treated with the PulseSelect™ PFA System and followed through 36 months....

Chicago, IL580 participantsMedtronic Cardiac Ablation Solutions

View Study Details

NCT07308847Recruiting

Horizon 360 Protocol for the Treatment of Paroxysmal Atrial Fibrillation With the Sphere-360™ Catheter and Affera™ Mapping and Ablation System (Horizon 360)

The study is a prospective, single-arm, pre-market clinical study and will enroll up to 300 subjects at up to 26 sites in the United States (US) for analysis of primary objectives. No single site may ...

Chicago, ILNA300 participantsMedtronic Cardiac Ablation Solutions

View Study Details

NCT03168659Recruiting

CardioFocus HeartLight Post-Approval Study

This is a post-approval study to evaluate the clinical outcomes in a cohort of participants treated during commercial use of the HeartLight System to confirm results of the previously conducted pivota...

Chicago, ILNA250 participantsCardioFocus

View Study Details

NCT06499857Recruiting

Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation

The goal of the study is to learn how a weight loss medication called semaglutide, which is used to treat obesity, in addition to standard AF treatment might affect AF, atrial fibrillation severity, a...

Chicago, ILPHASE3200 participantsUniversity of Chicago

View Study Details

NCT02347111Recruiting

Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

In this pilot and feasibility study, the investigators will enroll patients with frequent symptomatic episodes of atrial fibrillation (AF) in a cross-over study testing two different classes of anti a...

Chicago, ILPHASE4162 participantsUniversity of Illinois at Chicago

View Study Details

NCT04380740Recruiting

Extended vs Short-term Abatacept Dosing for Graft Versus Host Disease Prophylaxis

This is a multicenter randomized, double blind, Phase 2 trial for patients receiving transplants from 7 of 8 HLA matched donors, in which an extended dosing regimen of abatacept, and a short-term dosi...

Chicago, ILPHASE2160 participantsBoston Children's Hospital

View Study Details

NCT06538584Recruiting

Dex +/- Caffeine Sedation in a Post-MRI Recovery in a Pediatric Population

Dexmedetomidine (Dex), a selective α2-adrenergic receptor agonist, is the most used sedative for procedural sedation in children and in pediatric Intensive Care Unit (PICU) because it is associated wi...

Chicago, ILPHASE1100 participantsUniversity of Chicago

View Study Details

NCT07713849Recruiting

Transition Care for FEP

This study is testing a new approach to help people with first episode psychosis transition successfully from the hospital to outpatient mental health care. Many patients lose contact with services af...

Chicago, IL75 participantsUniversity of Chicago

View Study Details

NCT06063538Recruiting

Prevention of Postoperative Atrial Fibrillation (POAF) Using Intra-Pericardial Amiodarone

The purpose of this study is to evaluate the combination of CardiaMend, with the addition of amiodarone in the prevention of postoperative atrial fibrillation (POAF) in patients undergoing cardiac art...

Chicago, ILEARLY_PHASE163 participantsUniversity of Chicago

View Study Details

NCT06663722Recruiting

Axatilimab in Combination With Extracorporeal Photopheresis (ECP) in Chronic Graft-versus-Host Disease

The purpose of this study is to see whether giving participants a combination treatment of Axatilimab and Extracorporeal Photopheresis (ECP) is effective against chronic Graft-versus-Host Disease (cGV...

Chicago, ILPHASE249 participantsUniversity of Miami

View Study Details

NCT06619561Recruiting

A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)

The purpose of this study is to determine if vimseltinib is safe, tolerable and works effectively to treat adults with active moderate to severe cGVHD. Participants will be treated with vimseltinib in...

Chicago, ILPHASE248 participantsDeciphera Pharmaceuticals, LLC

View Study Details

NCT07324772Recruiting

PREACTIVE: Preconditioning Exercise Intervention to Improve Symptoms and Quality of Life in Comorbid Atrial Fibrillation and HFpEF

Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) are very common conditions that often occur together and result in worsening symptoms and reduced quality of life (Q...

Chicago, ILNA30 participantsNorthwestern University

View Study Details

NCT06343831Recruiting

Quantitative Assessment of Autologous Fat Transfer

This is a single-arm, prospective pilot study that will objectively assess outcomes in patients electively undergoing Autologous Fat Transfer (AFT) for breast or chest wall reconstruction. Patients pl...

Chicago, ILNA15 participantsUniversity of Chicago

View Study Details

About Atrial Fibrillation Clinical Trials in Chicago

Atrial fibrillation (AFib) is the most common type of heart arrhythmia, causing an irregular and often rapid heartbeat. It significantly increases the risk of stroke, heart failure, and other complications. Treatment includes blood thinners, heart rate or rhythm control medications, and procedures like ablation.

There are currently 17 atrial fibrillation clinical trials recruiting participants in Chicago, IL. These studies are seeking a combined 5,779 participants. Research is being sponsored by CorVita Science Foundation, Northwestern University, AtriCure, Inc. and 8 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Atrial Fibrillation Clinical Trials in Chicago — FAQ

Are there atrial fibrillation clinical trials in Chicago?

Yes, there are 17 atrial fibrillation clinical trials currently recruiting in Chicago, IL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chicago?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you about next steps.

Are clinical trials in Chicago free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chicago studies also compensate for your time and travel.

What atrial fibrillation treatments are being tested?

The 17 active trials in Chicago are testing new therapies including novel drugs, biologics, and treatment approaches for atrial fibrillation.

Data updated September 1, 2026 from ClinicalTrials.gov