36 Stroke Clinical Trials in Chicago, IL (2026)

Q: How do I join a clinical trial in Chicago?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you.

Recruiting Stroke Studies in Chicago

NCT04916210Recruiting

Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose ...

Chicago, IL8,000 participantsMassachusetts General Hospital

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NCT05911568Recruiting

Treatment With Endovascular Intervention for STroke Patients With Existing Disability

TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the br...

Chicago, IL1,060 participantsUniversity of Cincinnati

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NCT00682695Recruiting

Genetic and Environmental Risk Factors for Hemorrhagic Stroke

The purpose of this study is to find risk factors for hemorrhagic stroke....

Chicago, IL1,000 participantsState University of New York at Buffalo

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NCT06094478Recruiting

Hospital Implementation of a Stroke Protocol for Emergency Evaluation and Disposition

Most stroke patients are initially evaluated at the closest hospital but some need to be transferred to a hospital that can provide more advanced care. The "Door-In-Door-Out" (DIDO) process at the fir...

Chicago, ILNA900 participantsUniversity of Chicago

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NCT06990867Recruiting

Optimizing Reperfusion to Improve Outcomes and Neurologic Function

The goal of this study is to evaluate the safety and efficacy of JX10 versus placebo in participants with Acute Ischemic Stroke (AIS) who present for care within 4.5 to 24 hours. The main question th...

Chicago, ILPHASE2740 participantsCorxel Pharmaceuticals

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NCT06870812Recruiting

Rapid Evacuation and Access of Cerebral Hemorrhage Trial

The main purpose of this study is to compare patients with a deep bleed in the brain undergoing surgery to patients receiving routine medical care. The standard treatment involves admission to the Int...

Chicago, ILNA600 participantsEmory University

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NCT07115940Recruiting

Medical Management With Endovascular Thrombectomy Versus Medical Management Alone in Patients Presenting Beyond 24 Hours of Last Known Well

SELECT LATE trial aims to evaluate if addition of endovascular thrombectomy to medical management in patients presenting with acute ischemic stroke and a proximal large vessel occlusion in the anterio...

Chicago, ILNA408 participantsAmrou Sarraj

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NCT04219670Recruiting

Inpatient Stroke Recovery Using Sensors

This observational trial seeks to assess the feasibility of using non-invasive, portable, real-time body-worn sensors to continuously monitor, quantify, and interpret recovery during inpatient treatme...

Chicago, IL400 participantsShirley Ryan AbilityLab

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NCT05907629Recruiting

Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

CAPTIVA-MRI is an observational multimodal MR imaging study that is ancillary to the CAPTIVA trial \[a 3-arm, double-blind Phase III trial conducted at approximately 115 StrokeNet sites randomizing pa...

Chicago, IL300 participantsYale University

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NCT06029491Recruiting

The Pivotal Study of RapidPulseTM Aspiration System

The goal of this clinical trials is to demonstrate the safety and effectiveness for the RapidPulseTM Aspiration System in patients experiencing acute ischemic stroke within 8 hours of symptom onset or...

Chicago, ILNA170 participantsRapidPulse, Inc

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NCT05756257Recruiting

Blood Pressure Variability and Ischemic Stroke Outcome

The goal of this observational study is to evaluate the role of blood pressure (BPV) variability in patients suffering from acute ischemic stroke. The main questions it aims to answer are: 1. To dete...

Chicago, IL150 participantsYale University

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NCT06386874Recruiting

EMAGINE 2.0 - Electromagnetic Field Ischemic Stroke - Novel Subacute Treatment

This is a multicenter study that will be conducted at approximately 20 centers and up to 30 centers, if the sample size will be increased following interim assessment. The Q Therapeutic System (BQ 3....

Chicago, ILNA122 participantsBrainQ Technologies Ltd.

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NCT04165616Recruiting

Motor rECovery witH eArly imagiNg In STroke

This study will contribute to the field of stroke rehabilitation research by expanding the investigator's understanding of the neural mechanisms responsible for the development and expression of abnor...

Chicago, IL120 participantsNorthwestern University

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NCT03869138Recruiting

Alternative Therapies for Improving Physical Function in Individuals With Stroke

Neurological impairment is a devastating disease for patients and their families and a leading cause of adult disability. Traditional rehabilitative therapies can help regain motor function and amelio...

Chicago, ILNA120 participantsUniversity of Illinois at Chicago

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NCT05167786Recruiting

Locomotor Function Following Transcutaneous Electrical Spinal Cord Stimulation in Individuals With Hemiplegic Stroke

This study has two interventional components, the first is a cross-over design and the second is a randomized control trial. Both will evaluate the effectiveness of transcutaneous (non-invasive) spina...

Chicago, ILNA115 participantsShirley Ryan AbilityLab

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NCT04477330Recruiting

Cortical Priming to Optimize Gait Rehabilitation in Stroke: a Renewal

Achieving functional ambulation post stroke continues to be a challenge for stroke survivors, clinicians, and researchers. In the effort to enhance outcomes of motor training, cortical priming using b...

Chicago, ILNA100 participantsUniversity of Illinois at Chicago

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NCT03401762Recruiting

Wearable MCI to Reduce Muscle Co-activation in Acute and Chronic Stroke

The purpose of the study is to explore the feasibility of using a wearable device, called a myoelectric-computer interface (MCI), to improve arm movement in people who have had a stroke. Impaired arm...

Chicago, ILNA96 participantsNorthwestern University

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NCT07041775Recruiting

MINT Conditioning to Improve Gait

This study will test the ability of myoelectric interface for neurorehabilitation (MINT) training to improve walking function....

Chicago, ILNA72 participantsNorthwestern University

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NCT04312269Recruiting

Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke

This study will examine the combination of myoelectric computer interface (MyoCI) training with targeted memory reactivation (TMR) in chronic stroke survivors. The study aims to determine whether this...

Chicago, ILNA70 participantsNorthwestern University

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NCT06666673Recruiting

Effect of Neural Constraints on Movement in Stroke

This study investigates the effects of Tizanidine on the voluntary movement controls of the arms of participants who have had a stroke and have not had a stroke by measuring medication-induced changes...

Chicago, ILEARLY_PHASE164 participantsNorthwestern University

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NCT05194566Recruiting

Neurostimulation for the Treatment of Post-Stroke Aphasia

The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aph...

Chicago, ILNA64 participantsQVITI S.A.

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NCT06656754Recruiting

R01.Aim 2.Study 1: IsoReach

To determine the effects of 3D isometric movement training in healthy participants and impaired participants due to a stroke....

Chicago, ILEARLY_PHASE156 participantsShirley Ryan AbilityLab

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NCT06234124Recruiting

Characterization and Clinical Trial of a Variable Friction Shoe

More than one million Americans present with foot drop after stroke. As the aging population grows in the United States and across the world, incidence of stroke will grow as age is a key risk factor,...

Chicago, ILNA50 participantsShirley Ryan AbilityLab

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NCT07006818Recruiting

Impaired Interlimb Coordination During Locomotion in Individuals With Chronic Stroke: Contributors and Effect on Walking Function

Individuals with chronic stroke have long-term walking problems that limit community engagement and quality of life, lead to secondary disabilities, and increase healthcare costs and burden. These wal...

Chicago, ILNA50 participantsUniversity of Illinois at Chicago

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NCT06127602Recruiting

The REACTplusNMES Trial: A Double-blinded RCT

The aim of this study is to compare the effectiveness of 6-weeks of reactive balance training (REACT) with and without neuromuscular electrical stimulation (NMES) to paretic lower limb muscles on biom...

Chicago, ILNA46 participantsUniversity of Illinois at Chicago

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NCT07652970Recruiting

Tele-CE in Severe Stroke

The goal of this clinical trial is to determine the effects of home-based cross-education on lower limb neuroplasticity in severe stroke. The main questions the investigators aim to answer are: * Wh...

Chicago, ILNA40 participantsUniversity of Illinois at Chicago

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NCT03264261Recruiting

Constraint Induced Movement Therapy for Walking in Individuals Post Stroke

To compare the effect of constraint induced movement therapy (CIMT) vs. treadmill training only on walking function in individuals post-stroke, a 6 week, single-blind, randomized training study will b...

Chicago, ILNA36 participantsShirley Ryan AbilityLab

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NCT05644522Recruiting

Nomad P-KAFO Study

The goal of this clinical trial is to evaluate the impact of using the Nomad powered KAFO in people who have had a musculoskeletal or neurological injury that has affected their ability to walk. The m...

Chicago, ILNA36 participantsShirley Ryan AbilityLab

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NCT06598150Recruiting

Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke

This study uses functional magnetic resonance imaging to map neural activity throughout the central nervous system during a shoulder abduction task to characterize what motor pathways are being used p...

Chicago, ILNA32 participantsNorthwestern University

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NCT06655636Recruiting

Safety and Feasibility of an ExoNET for Supination Assistance for Stroke Survivors

The purpose of this study is to evaluate the safety, feasibility, and efficacy of an exoskeletal network of passive, multi-joint springs for forearm supination. Also known as the forearm ExoNET, the d...

Chicago, ILNA30 participantsShirley Ryan AbilityLab

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NCT06400186Recruiting

Movement Amplification Gait Training to Enhance Walking Balance Post-Stroke

Stroke is a leading cause of disability in the United States, affecting approximately 795,000 people annually. The Veteran's Health Administration provides over 60,000 outpatient visits for stroke-rel...

Chicago, ILNA30 participantsVA Office of Research and Development

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NCT05849532Recruiting

Home-based FES Training in People With Chronic Stroke

This project will examine the feasibility, safety and effect of home-based functional electrical stimulation (FES) applied to different lower limb muscles in combination with task-specific training on...

Chicago, ILNA30 participantsUniversity of Illinois at Chicago

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NCT04957355Recruiting

Effect of NMES on Balance and Fall Risk in Chronic Stroke

The aim of this study is to describe the effect of neuromuscular electrical stimulation (NMES) in the form of functional electrical stimulation (FES) applied to different lower limb muscles on reactiv...

Chicago, ILNA20 participantsUniversity of Illinois at Chicago

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NCT07061691Recruiting

WIM Exosuit Wearable Soft Robot for Enhancing Walking Activity

This study is to develop, test, and optimize a soft hip wearable robot for individuals who have experience a stroke....

Chicago, ILNA20 participantsShirley Ryan AbilityLab

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NCT05180786Recruiting

Error-enhanced Learning & Recovery in 2 & 3 Dimensions

This study is being done to see how errors lead to improvement. Specifically, we are evaluating the errors stroke participants make during an upper extremity exercise program when reaching for a targe...

Chicago, ILNA20 participantsShirley Ryan AbilityLab

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NCT06950593Recruiting

Transcutaneous Electrical Stimulation for Stroke Patients

This study aims to evaluate the feasibility and impact of transcutaneous electrical stimulation of the spinal cord (TESS) on the recovery of post-stroke individuals who have upper limb hemiparesis. It...

Chicago, ILNA14 participantsShirley Ryan AbilityLab

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About Stroke Clinical Trials in Chicago

A stroke occurs when blood flow to part of the brain is interrupted or reduced, depriving brain tissue of oxygen and nutrients. It is a leading cause of disability and death. Rapid treatment is critical, and prevention focuses on managing risk factors like hypertension and atrial fibrillation.

There are currently 36 stroke clinical trials recruiting participants in Chicago, IL. These studies are seeking a combined 15,181 participants. Research is being sponsored by Massachusetts General Hospital, University of Cincinnati, State University of New York at Buffalo and 12 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Stroke Clinical Trials in Chicago — FAQ

Are there stroke clinical trials in Chicago?

Yes, there are 36 stroke clinical trials currently recruiting in Chicago, IL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chicago?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you about next steps.

Are clinical trials in Chicago free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chicago studies also compensate for your time and travel.

What stroke treatments are being tested?

The 36 active trials in Chicago are testing new therapies including novel drugs, biologics, and treatment approaches for stroke.

Data updated July 17, 2026 from ClinicalTrials.gov