19 Hypertension Clinical Trials in Chicago, IL (2026)

Q: How do I join a clinical trial in Chicago?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you.

Recruiting Hypertension Studies in Chicago

NCT04755153Recruiting

Community Intervention to Reduce CardiovascuLar Disease in Chicago

Hypertension affects 1 in every 3 adults in the US and contributes to 410,000 deaths annually. Hypertension and its associated complications disproportionately affect minority populations living in ur...

Chicago, ILNA2,000 participantsNorthwestern University

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NCT06911632Recruiting

Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension

MOMENTOUS is a multi-center, randomized study to prospectively evaluate the performance of an ECG-based AI device to predict whether participants with interstitial lung disease (ILD) are at high risk ...

Chicago, ILNA900 participantsTempus AI

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NCT04967989Recruiting

Clarifying the Optimal Application of SLT Therapy Trial

The goal of this study is to understand if SLT performed at low energy is as effective as SLT performed at standard energy, and also to see if repeating SLT at low energy once a year will prevent or d...

Chicago, ILPHASE3790 participantsUniversity of Pittsburgh

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NCT06220721Recruiting

Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia

The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversal of vascular dysfun...

Chicago, ILNA618 participantsMedical College of Wisconsin

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NCT07288398Recruiting

LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

The purpose of this study is to assess the efficacy and safety of the study drug, levosimendan (given orally), compared to placebo in participants with pulmonary hypertension with heart failure with p...

Chicago, ILPHASE3540 participantsTenax Therapeutics, Inc.

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NCT07540143Recruiting

The REACH-OUT Trial

Test the effectiveness of a technology-enabled strategy to optimize blood pressure among reproductive-aged women with hypertension receiving care in Federally Qualified Health Centers....

Chicago, ILNA350 participantsNorthwestern University

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NCT07285655Recruiting

A Phase 3 Study to Evaluate the Safety and Efficacy L606 in Participants With PH-ILD

The purpose of this study is to find out if L606 is safe and if it helps people with high blood pressure in the lungs (pulmonary hypertension) caused by interstitial lung disease (PH-ILD, WHO Group 3)...

Chicago, ILPHASE3344 participantsLiquidia Technologies, Inc.

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NCT06274801Recruiting

Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)

This open-label extension study will evaluate the long-term safety, tolerability and efficacy of orally inhaled seralutinib in subjects who have completed a previous seralutinib study...

Chicago, ILPHASE3330 participantsGB002, Inc.

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NCT07543120Recruiting

An Open-label Extension Safety and Efficacy Study of QCZ484 in Hypertensive Patients.

The purpose of this extension study is to collect additional safety and efficacy on QCZ484 for hypertensive patients who successfully completed the parent study, CQCZ484A12201 or additional QCZ484 stu...

Chicago, ILPHASE2323 participantsNovartis Pharmaceuticals

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NCT06899750Recruiting

E3 Hypertension - A Team-based, Multidisciplinary Model in Addressing Barriers to Hypertension Control

This study aims to compare a multidisciplinary clinical hypertension and social needs intervention to enhanced standard of care for hypertension management in primary care clinics with regards to hype...

Chicago, ILNA200 participantsRush University Medical Center

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NCT07547345Recruiting

Mobilizing Community Hypertension Access Pilot

The Live Healthy Chicago (LHC) Community Pilot is a prospective, community-based study evaluating the feasibility, effectiveness, and economic impact of a pharmacist-led hypertension management progra...

Chicago, ILNA200 participantsRush University Medical Center

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NCT06843577Recruiting

A Pivotal Study to Evaluate the Effectiveness of Isometric Handgrip Therapy in Elevated Blood Pressure and Hypertensive Subjects

The study will be a multi-center, randomized clinical trial to evaluate the safety and efficacy of using the Zona Plus handgrip therapy device compared to the use of an auditory relaxation therapy for...

Chicago, ILNA160 participantsZona Health, Inc

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NCT07693699Recruiting

Optimizing Sustainable Cuff Access and Training Pathways for Self-Measured Blood Pressure Monitoring in Primary Care

The goal of this study is to identify what cuff delivery and training strategies most effectively achieve successful delivery of a self-measured blood pressure (SMBP) intervention in routine care, amo...

Chicago, ILNA150 participantsWake Forest University Health Sciences

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NCT07332741Recruiting

FIM+DASH: Food is Medicine Intervention to Promote Healthy Eating and Blood Pressure Control

The goal of this clinical trial is to treat both hypertension and obesity in adults using a food is medicine framework. Participants will be randomized 1:1 to FIM+DASH or usual-care control. The 24-we...

Chicago, ILPHASE2150 participantsUniversity of Illinois at Chicago

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NCT07511361Recruiting

Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension

The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who were recently hospitalized and concurrently experienced an episode of acute severe ...

Chicago, ILPHASE2140 participantsKardigan, Inc.

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NCT06466161Recruiting

Conical Forearm and Cylindrical Upper Arm Non-Invasive Blood Pressure (NIBP) Measurements in Pregnant Patients

The diagnosis of hypertensive disease during pregnancy is predicated on strict blood pressure thresholds: 140/90 on at least two occasions measured four hours apart for both gestational hypertension a...

Chicago, ILNA110 participantsNorthwestern University

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NCT06555952Recruiting

MegaNatural BP® GSE on Blood Pressure and Cardiometabolic Risk Factors

Inflammation and stressors can interfere with the function of the lining of blood vessels and insulin activity, therefore, investigators are aiming to see how the Grape seed Extract (GSE) called MegaN...

Chicago, ILNA80 participantsClinical Nutrition Research Center, Illinois Institute of Technology

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NCT06504914Recruiting

Preparing FIM-BCS - A Lifestyle Modification for African-American Breast Cancer Survivors

Hypertension and obesity are both major risk factors for cardiovascular disease (CVD), a leading cause of death for Black women in the United States. The investigators propose examining the feasibilit...

Chicago, ILNA24 participantsUniversity of Illinois at Chicago

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NCT07333183Recruiting

A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD

This is a Phase 2, open-label, multi-center clinical study to evaluate the safety and tolerability of inhaled mosliciguat in participants with pulmonary hypertension associated with interstitial lung ...

Chicago, ILPHASE220 participantsPulmovant, Inc.

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About Hypertension Clinical Trials in Chicago

Hypertension, or high blood pressure, is a common condition that increases the risk of heart disease, stroke, and kidney damage. Often called the "silent killer" because it usually has no symptoms. Management includes lifestyle modifications and medications to lower blood pressure.

There are currently 19 hypertension clinical trials recruiting participants in Chicago, IL. These studies are seeking a combined 7,429 participants. Research is being sponsored by Northwestern University, Tempus AI, University of Pittsburgh and 12 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Hypertension Clinical Trials in Chicago — FAQ

Are there hypertension clinical trials in Chicago?

Yes, there are 19 hypertension clinical trials currently recruiting in Chicago, IL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chicago?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you about next steps.

Are clinical trials in Chicago free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chicago studies also compensate for your time and travel.

What hypertension treatments are being tested?

The 19 active trials in Chicago are testing new therapies including novel drugs, biologics, and treatment approaches for hypertension.

Data updated September 5, 2026 from ClinicalTrials.gov