10 Peripheral Artery Disease Clinical Trials in Chicago, IL (2026)

Q: How do I join a clinical trial in Chicago?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you.

Recruiting Peripheral Artery Disease Studies in Chicago

NCT01904851Recruiting

Multi-Center Registry for Peripheral Arterial Disease Interventions and Outcomes

XLPAD is an observational study designed to evaluate the effectiveness and use of stent and non-stent based therapies among PAD patients. The study will create a registry that will include entry of pr...

Chicago, IL14,000 participantsBaylor Research Institute

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NCT04774159Recruiting

Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

The Low dose ColchicinE in pAtients with peripheral Artery DiseasE to address residual vascular Risk (LEADER-PAD) trial will evaluate if anti-inflammatory therapy with colchicine will reduce vascular ...

Chicago, ILPHASE36,150 participantsPopulation Health Research Institute

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NCT06686121Recruiting

Improving Mobility After Revascularization in Peripheral Artery Disease

Lower extremity revascularization combined with supervised exercise significantly improves walking performance compared to revascularization alone in people who have PAD without limb threatening ische...

Chicago, ILPHASE3386 participantsNorthwestern University

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NCT04228978Recruiting

Promote Weight Loss in Obese Peripheral Artery Disease (PAD) Patients to Prevent Mobility Loss

The PROVE Trial is a randomized clinical trial that will determine whether a weight loss intervention combined with walking exercise achieves greater improvement or less decline in six-minute walk dis...

Chicago, ILNA212 participantsNorthwestern University

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NCT05624125Recruiting

BEETroot Juice to Reverse Functional Impairment in PAD

The BEET PAD Trial is a multi-centered double-blind randomized clinical trial designed to determine whether beetroot juice, compared to placebo, improves six-minute walk distance at four month follow-...

Chicago, ILNA210 participantsNorthwestern University

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NCT06032065Recruiting

SMART Exercise for PAD

Supervised exercise therapy (SET), consisting of treadmill exercise conducted three times weekly at a center while supervised by healthcare personnel, is first line therapy for people disabled by lowe...

Chicago, ILPHASE3210 participantsNorthwestern University

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NCT06657976Recruiting

Response to Exercise and Nitric Oxide in PAD

RESIST PAD is a randomized trial of 200 PAD patients to establish: 1) whether a 12-week exercise intervention significantly increases Δ nitrite at 12-week follow-up, compared to control; 2) whether ex...

Chicago, ILPHASE2200 participantsNorthwestern University

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NCT04794530Recruiting

The COCOA-PAD II Trial

Among people with peripheral artery disease (PAD) age 55 and older, the investigators will test the hypothesis that PAD participants randomized to cocoa flavanols will have greater improvement or less...

Chicago, ILPHASE3190 participantsNorthwestern University

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NCT06399809Recruiting

Fisetin to Reduce Senescence and Mobility Impairment in PAD

The investigators propose a pilot randomized trial to gather preliminary data to test the hypothesis that Fisetin will reduce abundance of senescent cells in blood, skeletal muscle, and both subcutane...

Chicago, ILPHASE234 participantsNorthwestern University

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NCT06399900Recruiting

ENhancing Exercise With LIGHT to Improve Functioning in PAD

The ENLIGHTEN PAD Trial will collect preliminary data to test whether daily 660 nm light treatment of the lower extremities immediately before home-based walking exercise sessions improves six-minute ...

Chicago, ILNA32 participantsNorthwestern University

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About Peripheral Artery Disease Clinical Trials in Chicago

Peripheral artery disease (PAD) is a circulatory condition where narrowed arteries reduce blood flow to the limbs, especially the legs. Common symptoms include leg pain when walking (claudication). Treatment includes lifestyle changes, medications, and sometimes procedures to improve blood flow.

There are currently 10 peripheral artery disease clinical trials recruiting participants in Chicago, IL. These studies are seeking a combined 21,624 participants. Research is being sponsored by Baylor Research Institute, Population Health Research Institute, Northwestern University. Clinical trial participation is free and participants receive study-related medical care at no cost.

Peripheral Artery Disease Clinical Trials in Chicago — FAQ

Are there peripheral artery disease clinical trials in Chicago?

Yes, there are 10 peripheral artery disease clinical trials currently recruiting in Chicago, IL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chicago?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you about next steps.

Are clinical trials in Chicago free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chicago studies also compensate for your time and travel.

What peripheral artery disease treatments are being tested?

The 10 active trials in Chicago are testing new therapies including novel drugs, biologics, and treatment approaches for peripheral artery disease.

Data updated July 16, 2026 from ClinicalTrials.gov