La Jolla, CANCT05682677Now EnrollingIRB Ready

Depression Clinical Trial in La Jolla, CA

Access cutting-edge depression treatment through this clinical trial at a research site in La Jolla. Study-provided care at no cost to qualified participants.

Sponsored by University of California, San Diego

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Expert Care in La Jolla

Access depression specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related depression treatment provided free

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Check if you qualify for this depression clinical trial in La Jolla, CA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to La Jolla

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit La Jolla site if eligible
  4. 4Begin participation

About This Depression Study in La Jolla

The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective for treating depression in Service Members, Veterans, and civilians who have sustained a mild TBI. Participants will receive PACT plus 20 sessions of iTBS or sham iTBS over 4 weeks. Assessments will occur at baseline, 2 weeks, 4 weeks, and 8 weeks. Researchers will compare the PACT+iTBS group to the PACT+sham iTBS group to see if PACT+iTBS is associated with more depression improvement.

Sponsor: University of California, San Diego

Who Can Participate

Inclusion Criteria

Male or female
All racial and ethnic groups
Ages 18 to 65
Military service members receiving treatment at NMCSD or civilians receiving treatment at UCSD Health
History of mild TBI (as defined by the DoD/VA criteria used in conjunction with the OSU TBI-ID method) over 3 months prior to study entry
Meets criteria for current Major Depressive Episode within the context of Major Depressive Disorder, per MINI
Score of 18 or higher on the HAMD-17, indicating moderate to severe depressive symptoms
Stable on psychiatric medications for 6 weeks, with no changes to psychiatric medications expected during the study period
No contraindications to TMS (passes the TMS Adult Safety Screening questionnaire)
No contraindications to MRI (passes MRI safety screening questionnaire)
Able to commit to the treatment schedule
Able to complete assessment procedures in English
Intact decision-making capacity and ability to provide voluntary informed consent

Exclusion Criteria

History of moderate, severe, or penetrating TBI
History of other neurological condition unrelated to TBI, including but not limited to: conditions associated with increased intracranial pressure; space occupying brain lesions; cerebral aneurysm; stroke; transient ischemic attack within past two years; Parkinson's disease; Huntington's disease; dementia; multiple sclerosis; history of brain surgery; epilepsy; seizure except those therapeutically induced by electroconvulsive therapy (ECT) or a febrile seizure of infancy
Implanted medical devices including cardiac pacemaker, medication pump, aneurysm clip, shunt, stimulator, cochlear implant, electrodes, or any other metal object within or near the head (excluding the mouth) that cannot be safely removed
Active manic or psychotic illness per MINI
Current substance use disorder per MINI
Current active suicidal or homicidal ideation
Pregnant or intending to become pregnant within the study period; breastfeeding
Other sensory conditions or illnesses precluding participation in assessments or treatment
Current dose of lorazepam 2 mg or greater daily (or benzodiazepine equivalent) or any anticonvulsant due to the potential to limit iTBS efficacy
Taking medication that lowers seizure threshold
Previous failed treatment with rTMS, iTBS, or ECT
Completed \>4 sessions of cognitive rehabilitation within the last 3 years

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in La Jolla?

Yes, this clinical trial (NCT05682677) has an active research site in La Jolla, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Depression Treatment Options in La Jolla, CA

If you're searching for depression treatment options in La Jolla, CA, this clinical trial (NCT05682677) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our La Jolla research site is actively enrolling participants for this clinical trial. You'll receive care from experienced depression specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all depression clinical trials near you to find additional studies recruiting in your area.

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