St Louis, MONCT07473843Now EnrollingIRB Ready

Homozygous Familial Hypercholesterolemia Clinical Trial in St Louis, MO

Access cutting-edge homozygous familial hypercholesterolemia treatment through this phase 3 clinical trial at a research site in St Louis. Study-provided care at no cost to qualified participants.

Sponsored by Arrowhead Pharmaceuticals

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Expert Care in St Louis

Access homozygous familial hypercholesterolemia specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related homozygous familial hypercholesterolemia treatment provided free

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Why Participate?

  • No-Cost Study Care

  • Local to St Louis

    Convenient for MO residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit St Louis site if eligible
  4. 4Begin participation

About This Homozygous Familial Hypercholesterolemia Study in St Louis

This study will evaluate the efficacy and safety of zodasiran subcutaneous (sc) injection in participants 12 to \<18 years of age with genetically or clinically diagnosed homozygous familial hypercholesterolemia (HoFH) and low-density lipoprotein cholesterol (LDL-C) ≥116 milligrams per deciliter (mg/dL) on maximally tolerated lipid-lowering therapy.

Sponsor: Arrowhead Pharmaceuticals

Who Can Participate

Inclusion Criteria

Adolescents 12 to \<18 years of age who are nonpregnant, nonlactating, and do not plan to become pregnant during the study
Body weight ≥35 kilograms (kg) at screening
HoFH based on a supportive genetic test (from a source-verifiable medical record or based on screening genotype) or clinical diagnosis
Screening LDL-C ≥116 mg/dL (3 mmol/L)
Screening hemoglobin A1c (HbA1c) ≤9.5%
Total bilirubin \<2×upper limit of normal (ULN), unless in previously confirmed cases of Gilbert's syndrome
Alanine aminotransferase or aspartate aminotransferase \<3×ULN

Exclusion Criteria

Use of a hepatocyte-targeted siRNA within 365 days before Day 1 (except inclisiran, which is permitted; administration of inclisiran and study drug must be separated by at least 4 weeks)
Use of an antisense oligonucleotide molecule within 3 months before Day 1
Use of evinacumab within 3 months before Day 1
Use of systemic corticosteroids (unless used as replacement therapy for pituitary/adrenal disease with a stable regimen) NOTE: Additional inclusion/exclusion criteria may apply per protocol

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in St Louis?

Yes, this clinical trial (NCT07473843) has an active research site in St Louis, MO that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Homozygous Familial Hypercholesterolemia Treatment Options in St Louis, MO

If you're searching for homozygous familial hypercholesterolemia treatment options in St Louis, MO, this clinical trial (NCT07473843) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our St Louis research site is actively enrolling participants for this phase 3 clinical trial. You'll receive care from experienced homozygous familial hypercholesterolemia specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all homozygous familial hypercholesterolemia clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · St Louis, MO