NCT06214923 · University of Maryland, Baltimore
Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG)
(VR TMD EEG)
What this study is about
This project examines, in chronic pain, the mechanisms of immersive virtual reality compared to the mechanisms of placebo hypoalgesia. The potential of developing new non-pharmacological premises for low-risk interventions for pain management is high.
View original scientific description
This project examines, in chronic pain, the mechanisms of immersive virtual reality compared to the mechanisms of placebo hypoalgesia. The potential of developing new non-pharmacological premises for low-risk interventions for pain management is high.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Age (18-88 years)
- English speaker (written and spoken)
- Temporal Mandibular Disorder (TMD) for at least 3 months
- TMD Grade Chronic Pain Scale (GCPS) ≥ 0
Exclusion criteria
- Present or past degenerative neuromuscular disease
- Cardiovascular, neurological diseases, pulmonary abnormalities, kidney disease, liver disease, history of cancer within past 3 years
- Cervical pain (e.g. stenosis, radiculopathy)
- Any personal (or family first degree) history of mania, schizophrenia, or other psychoses
- Severe psychiatric condition (e.g. schizophrenia, bipolar disorders, autism) leading to hospitalization within the last 3 years.
- Use of Antipsychotics (e.g., Risperdal, Ability and clozaril)Lifetime alcohol/drug dependence or alcohol/drug abuse in past 3 months
- Pregnancy or breast feeding
- Color-blindness
- Impaired or uncorrected hearing
- Non-dominant hand
- Any facial trauma that has occurred in the last 6 weeks
- History of a severe facial trauma in the last 2-3 months
- Conditions that would interfere with the VR mask placement (e.g. trauma, burn, infection)
- Known history of severe motion sickness
- Non-removable head cover, artificial hair, certain types of braids or dreadlocks
- History of fainting
- History of angioedema
- Failed drug test (testing for opiates, cocaine, methamphetamines, and amphetamines)
Where
- Baltimore, Maryland
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jul 7, 2026 · Source of record for eligibility and locations